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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2019; Volume 370,Issue 2

Minireviews

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    Contrast Induced Acute Kidney Injury and Direct Cytotoxicity of Iodinated Radiocontrast Media on Renal Proximal Tubule Cells
    Dakota B. Ward and Monica A. Valentovic
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 160-171; DOI: https://doi.org/10.1124/jpet.119.257337
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    Engineered Mesenchymal Stem Cells for Targeting Solid Tumors: Therapeutic Potential beyond Regenerative Therapy
    Shen Cheng, Susheel Kumar Nethi, Sneha Rathi, Buddhadev Layek and Swayam Prabha
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 231-241; DOI: https://doi.org/10.1124/jpet.119.259796

Cardiovascular

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    Pharmacology of Ranolazine versus Common Cardiovascular Drugs in Patients with Early Diastolic Dysfunction Induced by Anthracyclines or Nonanthracycline Chemotherapeutics: A Phase 2b Minitrial
    Giorgio Minotti, Pierantonio Menna, Vito Calabrese, Carlo Greco, Grazia Armento, Ombretta Annibali, Francesco Marchesi, Emanuela Salvatorelli and Giorgio Reggiardo
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 197-205; DOI: https://doi.org/10.1124/jpet.119.258178
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    Protamine Sulfate Induces Mitochondrial Hyperpolarization and a Subsequent Increase in Reactive Oxygen Species Production
    Rabia Ramzan, Susanne Michels, Petra Weber, Annika Rhiel, Marc Irqsusi, Ardawan J. Rastan, Carsten Culmsee and Sebastian Vogt
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 308-317; DOI: https://doi.org/10.1124/jpet.119.257725

Cellular and Molecular

  • Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models
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    Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models
    M. Jove, J.A. Spencer, M.E. Hubbard, E.C. Holden, R.D. O’Dea, B.S. Brook, R.M. Phillips, S.W. Smye, P.M. Loadman and C.J. Twelves
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 242-251; DOI: https://doi.org/10.1124/jpet.119.256693
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    Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath
    Kangjiao Yan, Xiaoying Sun, Gongxin Wang, Yani Liu and KeWei Wang
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 299-307; DOI: https://doi.org/10.1124/jpet.119.258087

Drug Discovery and Translational Medicine

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    Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs
    Scott J. Weir, Robyn Wood, Karl Schorno, Amanda E. Brinker, Prabhu Ramamoorthy, Kathy Heppert, Lian Rajewski, Mehmet Tanol, Tammy Ham, Michael J. McKenna, William McCulloch, Michael Dalton, Gregory A. Reed, Roy A. Jensen, Michael J. Baltezor, Shrikant Anant and John A. Taylor
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 148-159; DOI: https://doi.org/10.1124/jpet.119.257972
  • Open Access
    A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys
    Wouter Korver, Mary Carsillo, Josh Yuan, Neeraja Idamakanti, Matthew Wagoner, Pu Shi, Cindy Q. Xia, Glennda Smithson, Lachy McLean, Jonathan Zalevsky and Eric R. Fedyk
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 182-196; DOI: https://doi.org/10.1124/jpet.119.256602
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    Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy
    Jonathan Oliva, Scott Galasinski, Amelia Richey, Amy E. Campbell, Marvin J. Meyers, Neal Modi, Jun Wen Zhong, Rabi Tawil, Stephen J. Tapscott and Francis M. Sverdrup
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 219-230; DOI: https://doi.org/10.1124/jpet.119.259663
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    Blood Pharmacokinetics Imaging by Noninvasive Heart Fluorescence Tomography and Application to Kidney Glomerular Filtration Rate Assessment
    Bagna Bao, Kristine O. Vasquez, Guojie Ho, Jun Zhang, Jeannine Delaney, Milind Rajopadhye and Jeffrey D. Peterson
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 288-298; DOI: https://doi.org/10.1124/jpet.119.257071

Endocrine and Diabetes

  • Open Access
    SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity
    Hikaru Ueno, Ryo Ito, Shin-ichi Abe, Mitsugi Ookawara, Hirohisa Miyashita, Hitomi Ogino, Yasufumi Miyamoto, Tomoki Yoshihara, Akihiro Kobayashi, Yoshiyuki Tsujihata, Koji Takeuchi, Masanori Watanabe, Yukio Yamada, Tsuyoshi Maekawa, Nobuhiro Nishigaki and Yusuke Moritoh
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 172-181; DOI: https://doi.org/10.1124/jpet.118.255885

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury
    Chao Zhang, Xiaochen He, Sydney R. Murphy, Huawei Zhang, Shaoxun Wang, Ying Ge, Wenjun Gao, Jan M. Williams, Aron M. Geurts, Richard J. Roman and Fan Fan
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 206-217; DOI: https://doi.org/10.1124/jpet.119.258954

Inflammation, Immunopharmacology, and Asthma

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    Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats
    Marta Calbet, Isabel Ramis, Elena Calama, Cristina Carreño, Stephane Paris, Monica Maldonado, Adelina Orellana, Elena Calaf, Montse Pauta, Jorge De Alba, Jordi Bach and Montserrat Miralpeix
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 137-147; DOI: https://doi.org/10.1124/jpet.119.256263

Metabolism, Transport, and Pharmacogenomics

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    Mechanistic Basis of Cabotegravir–Glucuronide Disposition in Humans
    Mitesh Patel, H. Christian Eberl, Andrea Wolf, Esaie Pierre, Joseph W. Polli and Maciej J. Zamek-Gliszczynski
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 269-277; DOI: https://doi.org/10.1124/jpet.119.258384
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    Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir
    Matthew P. Kosloski, Daniel A.J. Bow, Ryota Kikuchi, Haoyu Wang, Elaine J. Kim, Kennan Marsh, Federico Mensa, Jens Kort and Wei Liu
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 278-287; DOI: https://doi.org/10.1124/jpet.119.256966
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    Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat
    Vivaswath S. Ayyar, Dawei Song, Debra C. DuBois, Richard R. Almon and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 318-326; DOI: https://doi.org/10.1124/jpet.119.257519
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    Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression
    Vivaswath S. Ayyar, Debra C. DuBois, Toshimichi Nakamura, Richard R. Almon and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 327-336; DOI: https://doi.org/10.1124/jpet.119.257527
  • Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor–Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids
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    Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor–Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids
    Vivaswath S. Ayyar, Debra C. DuBois, Richard R. Almon and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 337-349; DOI: https://doi.org/10.1124/jpet.119.257543

Neuropharmacology

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    Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators
    Clare Stokes, Sumanta Garai, Abhijit R. Kulkarni, Lucas N. Cantwell, Colleen M. Noviello, Ryan E. Hibbs, Nicole A. Horenstein, Khalil A. Abboud, Ganesh A. Thakur and Roger L. Papke
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 252-268; DOI: https://doi.org/10.1124/jpet.119.259499

Erratum

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    Correction to “Targeting Dopamine D2, Adenosine A2A, and Glutamate mGlu5Receptors to Reduce Repetitive Behaviors in Deer Mice
    Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 218; DOI: https://doi.org/10.1124/jpet.118.256081err2
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 370 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 370, Issue 2
1 Aug 2019
  • Table of Contents
  • Table of Contents (PDF)
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