Journal of Pharmacology and Experimental Therapeutics: 370 (1)

July 01, 2019; Volume 370,Issue 1

Minireviews

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Cancer and the Dopamine D₂ Receptor: A Pharmacological Perspective
Jillian S. Weissenrieder, Jeffrey D. Neighbors, Richard B. Mailman and Raymond J. Hohl

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 111-126; DOI: https://doi.org/10.1124/jpet.119.256818

Behavioral Pharmacology

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Impact of Pharmacological Manipulation of the κ-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice
Eduardo R. Butelman, Bryan D. McElroy, Thomas E. Prisinzano and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 1-8; DOI: https://doi.org/10.1124/jpet.119.256354
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In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome
Bryce A. Griffin, Caitlin O. Caperton, Lauren N. Russell, Christian V. Cabanlong, Catheryn D. Wilson, Kyle R. Urquhart, Bradford S. Martins, Marcelle Dina Zita, Amy L. Patton, Alexander W. Alund, S. Michael Owens, William E. Fantegrossi, Jeffery H. Moran and Lisa K. Brents

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 9-17; DOI: https://doi.org/10.1124/jpet.118.254219

Cardiovascular

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Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice
Lihong Chen, Guangrui Yang, Tingting Jiang, Soon Yew Tang, Tao Wang, Qing Wan, Miao Wang and Garret A. FitzGerald

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 18-24; DOI: https://doi.org/10.1124/jpet.118.256057

Cellular and Molecular

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Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells
Shailesh R. Agarwal, Chase Fiore, Kathryn Miyashiro, Rennolds S. Ostrom and Robert D. Harvey

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 104-110; DOI: https://doi.org/10.1124/jpet.119.256594

Drug Discovery and Translational Medicine

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The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia
Werner J. Geldenhuys, Rajesh R. Nair, Debbie Piktel, Karen H. Martin and Laura F. Gibson

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 25-34; DOI: https://doi.org/10.1124/jpet.118.255984
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The Dual Amylin and Calcitonin Receptor Agonist KBP-088 Induces Weight Loss and Improves Insulin Sensitivity Superior to Chronic Amylin Therapy
Anna Thorsø Larsen, Nina Sonne, Kim Vietz Andreassen, Kristoffer Gehring, Morten Asser Karsdal and Kim Henriksen

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 35-43; DOI: https://doi.org/10.1124/jpet.119.257576
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Therapeutic Monoclonal Antibody Antagonizing Endothelin Receptor A for Pulmonary Arterial Hypertension
Cheng Zhang, Xiaofeng Wang, Hua Zhang, Chenjiang Yao, Hao Pan, Yong Guo, Kesuo Fan and Shuqian Jing

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 54-61; DOI: https://doi.org/10.1124/jpet.118.252700
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Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M₃ Receptor Antagonist/β₂-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile
Mònica Aparici, Carla Carcasona, Israel Ramos, José Luís Montero, Raquel Otal, José Luís Ortiz, Julio Cortijo, Carlos Puig, Dolors Vilella, Jorge De Alba, Chris Doe, Amadeu Gavaldà and Montserrat Miralpeix

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 127-136; DOI: https://doi.org/10.1124/jpet.118.255620

Inflammation, Immunopharmacology, and Asthma

Open Access
Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation
Grace Hudson, Kyle L. Flannigan, Vivek Krishna Pulakazhi Venu, Laurie Alston, Christina F. Sandall, Justin A. MacDonald, Daniel A. Muruve, Thomas K.H. Chang, Sridhar Mani and Simon A. Hirota

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 44-53; DOI: https://doi.org/10.1124/jpet.118.255679
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Inhibitory Effect of Jing-Fang Powder n-Butanol Extract and Its Isolated Fraction D on Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells
Zhili Rao, Haijuan Cao, Boyu Shi, Xiaobo Liu, Jie Luo and Nan Zeng

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 62-71; DOI: https://doi.org/10.1124/jpet.118.255893

Metabolism, Transport, and Pharmacogenomics

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Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: “SLC-Phenotyping” Using Primary Human Hepatocytes
Yi-an Bi, Chester Costales, Sumathy Mathialagan, Mark West, Soraya Eatemadpour, Sarah Lazzaro, Laurie Tylaska, Renato J. Scialis, Hui Zhang, John Umland, Emi Kimoto, David A. Tess, Bo Feng, Larry M. Tremaine, Manthena V. S. Varma and A. David Rodrigues

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 72-83; DOI: https://doi.org/10.1124/jpet.119.257600
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Treatment of γ-Hydroxybutyric Acid and γ-Butyrolactone Overdose with Two Potent Monocarboxylate Transporter 1 Inhibitors, AZD3965 and AR-C155858
Kristin E. Follman and Marilyn E. Morris

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 84-91; DOI: https://doi.org/10.1124/jpet.119.256503
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Characterization of Vitamin A Metabolome in Human Livers With and Without Nonalcoholic Fatty Liver Disease
Guo Zhong, Jay Kirkwood, Kyoung-Jae Won, Natalie Tjota, Hyunyoung Jeong and Nina Isoherranen

Journal of Pharmacology and Experimental Therapeutics July 2019, 370 (1) 92-103; DOI: https://doi.org/10.1124/jpet.119.258517

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

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