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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2019; Volume 369,Issue 3

Minireviews

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    Perspectives on Wnt Signal Pathway in the Pathogenesis and Therapeutics of Chronic Obstructive Pulmonary Disease
    Jiao Qu, Li Yue, Jian Gao and Hongwei Yao
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 473-480; DOI: https://doi.org/10.1124/jpet.118.256222

Cardiovascular

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    The Supplement Adulterant β-Methylphenethylamine Increases Blood Pressure by Acting at Peripheral Norepinephrine Transporters
    Charles W. Schindler, Eric B. Thorndike, Kenner C. Rice, John S. Partilla and Michael H. Baumann
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 328-336; DOI: https://doi.org/10.1124/jpet.118.255976

Chemotherapy, Antibiotics, and Gene Therapy

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    Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination
    David Machover, Luigia Rossi, Jocelyne Hamelin, Christophe Desterke, Emma Goldschmidt, Bernadette Chadefaux-Vekemans, Pascal Bonnarme, Pierre Briozzo, David Kopečný, Francesca Pierigè, Mauro Magnani, Rosella Mollicone, Farhad Haghighi-Rad, Yann Gaston-Mathé, Julien Dairou, Claude Boucheix and Raphaël Saffroy
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 489-502; DOI: https://doi.org/10.1124/jpet.119.256537
  • Combining Multiscale Experimental and Computational Systems Pharmacological Approaches to Overcome Resistance to HER2-targeted Therapy in Breast Cancer
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    Combining Multiscale Experimental and Computational Systems Pharmacological Approaches to Overcome Resistance to HER2-targeted Therapy in Breast Cancer
    Tanaya R. Vaidya, Anusha Ande and Sihem Ait-Oudhia
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 531-545; DOI: https://doi.org/10.1124/jpet.118.255752

Drug Discovery and Translational Medicine

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    Effects of Tegoprazan, a Novel Potassium-Competitive Acid Blocker, on Rat Models of Gastric Acid–Related Disease
    Dong Kyu Kim, Keun-Ho Lee, Sung-jun Kim, Soo-Jin Kim, Song Jin Lee, Chi Hye Park, Bong-Tae Kim, Geun-Seog Song, Byoung-Seok Moon and Shin-Young Ryu
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 318-327; DOI: https://doi.org/10.1124/jpet.118.254904
  • Open Access
    Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib
    M. Begg, R. Wilson, J.N. Hamblin, M. Montembault, J. Green, A. Deans, A. Amour, S. Worsley, K. Fantom, Y. Cui, G. Dear, S. Ahmad, A. Kielkowska, J. Clark, M. Boyce, A. Cahn and E.M. Hessel
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 337-344; DOI: https://doi.org/10.1124/jpet.118.255109
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    Modulation of TARP γ8–Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain
    Kelly L. Knopp, Rosa Maria A. Simmons, Wenhong Guo, Benjamin L. Adams, Kevin M. Gardinier, Douglas L. Gernert, Paul L. Ornstein, Warren Porter, Jon Reel, Chunjin Ding, He Wang, Yuewei Qian, Kevin D. Burris, Anne Need, Vanessa Barth, Steven Swanson, John Catlow, Jeffrey M. Witkin, Ruud Zwart, Emanuele Sher, Kar-Chan Choong, Theron M. Wall, Douglas Schober, Christian C. Felder, Akihiko S. Kato, David S. Bredt and Eric S. Nisenbaum
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 345-363; DOI: https://doi.org/10.1124/jpet.118.250126
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    Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson’s Disease
    Patrick A. Howson, Tom H. Johnston, Paula Ravenscroft, Michael P. Hill, Jin Su, Jonathan M. Brotchie and James B. Koprich
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 364-374; DOI: https://doi.org/10.1124/jpet.118.255695
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    Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis
    Harvey Wong, Lichuan Liu, Wenjun Ouyang, Yuzhong Deng, Matthew R. Wright and Cornelis E.C.A. Hop
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 406-418; DOI: https://doi.org/10.1124/jpet.118.255562
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    Beneficial Metabolic Effects of Mirabegron In Vitro and in High-Fat Diet-Induced Obese Mice
    Lei Hao, Sheyenne Scott, Mehrnaz Abbasi, Yujiao Zu, Md Shahjalal Hossain Khan, Yang Yang, Dayong Wu, Ling Zhao and Shu Wang
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 419-427; DOI: https://doi.org/10.1124/jpet.118.255778
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    Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes
    Francois Pognan, Philippe Couttet, Ivan Demin, Birgit Jaitner, Yinuo Pang, Ronenn Roubenoff, Esther Sutter, Yoav Timsit, Marie Anne Valentin, Beate Vogel, Gaetane Woerly, Armin Wolf and Ursula Schramm
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 428-442; DOI: https://doi.org/10.1124/jpet.118.254128
  • Open Access
    AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A2: In Vivo Efficacy for Inflammation, Neuropathic Pain, and Pulmonary Fibrosis
    Hirotomo Shimizu, Akitoshi Ito, Katsuhiko Sakurada, Junji Nakamura, Kosuke Tanaka, Masakazu Komatsu, Mineko Takeda, Kenichi Saito, Yukiko Endo, Tomohito Kozaki, Motoshi Shoda and Hiroshi Kuriyama
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 511-522; DOI: https://doi.org/10.1124/jpet.118.255034

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    The Selective Sphingosine 1-Phosphate Receptor Modulator Etrasimod Regulates Lymphocyte Trafficking and Alleviates Experimental Colitis
    Hussien Al-Shamma, Karin Lehmann-Bruinsma, Chris Carroll, Michelle Solomon, H. Kiyomi Komori, Laurent Peyrin-Biroulet and John Adams
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 311-317; DOI: https://doi.org/10.1124/jpet.118.254268
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    Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet
    Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Takashi Sonobe, Mikiyasu Shirai and James T. Pearson
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 375-388; DOI: https://doi.org/10.1124/jpet.118.254821
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    Development and Characterization of a Novel, High-Affinity, Specific, Radiolabeled Ligand for BRS-3 Receptors
    Irene Ramos-Alvarez, Lingaku Lee, Samuel A. Mantey and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 454-465; DOI: https://doi.org/10.1124/jpet.118.255141
  • Open Access
    Role of Bitter Taste Receptors in Regulating Gastric Accommodation in Guinea Pigs
    Yumi Harada, Junichi Koseki, Hitomi Sekine, Naoki Fujitsuka and Hiroyuki Kobayashi
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 466-472; DOI: https://doi.org/10.1124/jpet.118.256008
  • Open Access
    CXA-10, a Nitrated Fatty Acid, Is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy
    Cynthia M. Arbeeny, Hong Ling, Mandy M. Smith, Stephen O’Brien, Stefan Wawersik, Steven R. Ledbetter, Allen McAlexander, Francisco J. Schopfer, Robert N. Willette and Diane K. Jorkasky
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 503-510; DOI: https://doi.org/10.1124/jpet.118.254755

Inflammation, Immunopharmacology, and Asthma

  • Open Access
    Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor
    Malcolm Begg, Chris D. Edwards, J. Nicole Hamblin, Eleni Pefani, Robert Wilson, Jane Gilbert, Giovanni Vitulli, David Mallett, Josie Morrell, Martin I. Hingle, Sorif Uddin, Filzah Ehtesham, Miriam Marotti, Andrew Harrell, Carla F. Newman, Disala Fernando, Jonathan Clark, Anthony Cahn and Edith M. Hessel
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 443-453; DOI: https://doi.org/10.1124/jpet.119.257311

Metabolism, Transport, and Pharmacogenomics

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    Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites
    Sumit Bansal and Aik Jiang Lau
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 389-405; DOI: https://doi.org/10.1124/jpet.119.256255
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    Apolipoprotein A-I Crosses the Blood-Brain Barrier through Clathrin-Independent and Cholesterol-Mediated Endocytosis
    Andrew L. Zhou, Suresh K. Swaminathan, Geoffry L. Curran, Joseph F. Poduslo, Val J. Lowe, Ling Li and Karunya K. Kandimalla
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 481-488; DOI: https://doi.org/10.1124/jpet.118.254201
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    Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing
    Aishwarya Jayagopal, Paul R. Brakeman, Peter Soler, Nicholas Ferrell, William Fissell, Deanna L. Kroetz and Shuvo Roy
    Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 523-530; DOI: https://doi.org/10.1124/jpet.118.255026
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 369 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 369, Issue 3
1 Jun 2019
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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