Journal of Pharmacology and Experimental Therapeutics: 369 (2)

May 01, 2019; Volume 369,Issue 2

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Artificial Oxygen Carriers—Past, Present, and Future—a Review of the Most Innovative and Clinically Relevant Concepts
Katja B. Ferenz and Andrea U. Steinbicker

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 300-310; DOI: https://doi.org/10.1124/jpet.118.254664

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Inhibition of Methamphetamine Self-Administration and Reinstatement by Central Blockade of Angiotensin II Receptor in Rats
Xing Xu, Jian Pan, Xingxing Li, Yan Cui, Zijuan Mao, Boliang Wu, Huachong Xu, Wenhua Zhou and Yu Liu

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 244-258; DOI: https://doi.org/10.1124/jpet.118.255729
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Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein–Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with Δ⁹-Tetrahydrocannabinol and JWH-018
Benjamin M. Ford, Christian V. Cabanlong, Sherrica Tai, Lirit N. Franks, Narsimha R. Penthala, Peter A. Crooks, Paul L. Prather and William E. Fantegrossi

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 259-269; DOI: https://doi.org/10.1124/jpet.118.252965

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Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury
Ahmed A. Mohsin, Qun Chen, Nanhu Quan, Thomas Rousselle, Michael W. Maceyka, Arun Samidurai, Jeremy Thompson, Ying Hu, Ji Li and Edward J. Lesnefsky

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 282-290; DOI: https://doi.org/10.1124/jpet.118.254300

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Targeting Thioredoxin Reductase by Ibrutinib Promotes Apoptosis of SMMC-7721 Cells
Xiao Han, Junmin Zhang, Danfeng Shi, Yueting Wu, Ruijuan Liu, Tianyu Liu, Jianqiang Xu, Xiaojun Yao and Jianguo Fang

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 212-222; DOI: https://doi.org/10.1124/jpet.118.254862
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Role of Protein Tyrosine Phosphatase Epsilon (PTPε) in Leukotriene D₄-Induced CXCL8 Expression
Fanny Lapointe, Sylvie Turcotte, Steeve Véronneau, Marek Rola-Pleszczynski and Jana Stankova

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 270-281; DOI: https://doi.org/10.1124/jpet.118.255422

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Acetylcholine Inhibits Platelet Activation
John A. Bennett, Sara K. Ture, Rachel A. Schmidt, Michael A. Mastrangelo, Scott J. Cameron, Lara E. Terry, David I. Yule, Craig N. Morrell and Charles J. Lowenstein

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 182-187; DOI: https://doi.org/10.1124/jpet.118.253583
Open Access
Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β₂-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies
Magdalena Koziczak-Holbro, Dean F. Rigel, Bérengère Dumotier, David A. Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bösch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moïse Azria, Robin A. Fairhurst, Steven J. Charlton, Brian P. Richardson, Estelle Lach-Trifilieff, David J. Glass, Thomas Ullrich and Shinji Hatakeyama

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 188-199; DOI: https://doi.org/10.1124/jpet.118.255307

Open Access
Characterizing Pharmacokinetic–Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation
Robbie L. McLeod, Malgorzata A. Gil, Dapeng Chen, Antonio Cabal, Jason Katz, Joey Methot, Janice D. Woodhouse, Lauren Dorosh, Prasanthi Geda, Khamir Mehta, Milenko Cicmil, Gretchen A. Baltus, Alan Bass, Hani Houshyar, Michael Caniga, Hongshi Yu, Francois Gervais, Stephen Alves and Sanjiv Shah

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 223-233; DOI: https://doi.org/10.1124/jpet.118.252551

Open Access
Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p
Aimee K. Sutliff, Christy J. W. Watson, Gang Chen and Philip Lazarus

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 234-243; DOI: https://doi.org/10.1124/jpet.118.255935
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Pharmacokinetic Study of Osimertinib in Cancer Patients with Mild or Moderate Hepatic Impairment
Enrique Grande, R. Donald Harvey, Benoit You, Jaime Feliu Batlle, Hal Galbraith, John Sarantopoulos, Suresh S. Ramalingam, Helen Mann, Karen So, Martin Johnson and Karthick Vishwanathan

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 291-299; DOI: https://doi.org/10.1124/jpet.118.255919

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Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane
Cheng Zhou, Kenneth W. Johnson, Karl F. Herold and Hugh C. Hemmings

Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 200-211; DOI: https://doi.org/10.1124/jpet.118.254938