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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2019; Volume 369,Issue 2

Minireviews

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    Artificial Oxygen Carriers—Past, Present, and Future—a Review of the Most Innovative and Clinically Relevant Concepts
    Katja B. Ferenz and Andrea U. Steinbicker
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 300-310; DOI: https://doi.org/10.1124/jpet.118.254664

Behavioral Pharmacology

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    Inhibition of Methamphetamine Self-Administration and Reinstatement by Central Blockade of Angiotensin II Receptor in Rats
    Xing Xu, Jian Pan, Xingxing Li, Yan Cui, Zijuan Mao, Boliang Wu, Huachong Xu, Wenhua Zhou and Yu Liu
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 244-258; DOI: https://doi.org/10.1124/jpet.118.255729
  • You have access
    Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein–Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with Δ9-Tetrahydrocannabinol and JWH-018
    Benjamin M. Ford, Christian V. Cabanlong, Sherrica Tai, Lirit N. Franks, Narsimha R. Penthala, Peter A. Crooks, Paul L. Prather and William E. Fantegrossi
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 259-269; DOI: https://doi.org/10.1124/jpet.118.252965

Cardiovascular

  • Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury
    You have access
    Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury
    Ahmed A. Mohsin, Qun Chen, Nanhu Quan, Thomas Rousselle, Michael W. Maceyka, Arun Samidurai, Jeremy Thompson, Ying Hu, Ji Li and Edward J. Lesnefsky
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 282-290; DOI: https://doi.org/10.1124/jpet.118.254300

Cellular and Molecular

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    Targeting Thioredoxin Reductase by Ibrutinib Promotes Apoptosis of SMMC-7721 Cells
    Xiao Han, Junmin Zhang, Danfeng Shi, Yueting Wu, Ruijuan Liu, Tianyu Liu, Jianqiang Xu, Xiaojun Yao and Jianguo Fang
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 212-222; DOI: https://doi.org/10.1124/jpet.118.254862
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    Role of Protein Tyrosine Phosphatase Epsilon (PTPε) in Leukotriene D4-Induced CXCL8 Expression
    Fanny Lapointe, Sylvie Turcotte, Steeve Véronneau, Marek Rola-Pleszczynski and Jana Stankova
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 270-281; DOI: https://doi.org/10.1124/jpet.118.255422

Drug Discovery and Translational Medicine

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    Acetylcholine Inhibits Platelet Activation
    John A. Bennett, Sara K. Ture, Rachel A. Schmidt, Michael A. Mastrangelo, Scott J. Cameron, Lara E. Terry, David I. Yule, Craig N. Morrell and Charles J. Lowenstein
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 182-187; DOI: https://doi.org/10.1124/jpet.118.253583
  • Open Access
    Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies
    Magdalena Koziczak-Holbro, Dean F. Rigel, Bérengère Dumotier, David A. Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bösch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moïse Azria, Robin A. Fairhurst, Steven J. Charlton, Brian P. Richardson, Estelle Lach-Trifilieff, David J. Glass, Thomas Ullrich and Shinji Hatakeyama
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 188-199; DOI: https://doi.org/10.1124/jpet.118.255307

Inflammation, Immunopharmacology, and Asthma

  • Open Access
    Characterizing Pharmacokinetic–Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation
    Robbie L. McLeod, Malgorzata A. Gil, Dapeng Chen, Antonio Cabal, Jason Katz, Joey Methot, Janice D. Woodhouse, Lauren Dorosh, Prasanthi Geda, Khamir Mehta, Milenko Cicmil, Gretchen A. Baltus, Alan Bass, Hani Houshyar, Michael Caniga, Hongshi Yu, Francois Gervais, Stephen Alves and Sanjiv Shah
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 223-233; DOI: https://doi.org/10.1124/jpet.118.252551

Metabolism, Transport, and Pharmacogenomics

  • Open Access
    Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p
    Aimee K. Sutliff, Christy J. W. Watson, Gang Chen and Philip Lazarus
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 234-243; DOI: https://doi.org/10.1124/jpet.118.255935
  • You have access
    Pharmacokinetic Study of Osimertinib in Cancer Patients with Mild or Moderate Hepatic Impairment
    Enrique Grande, R. Donald Harvey, Benoit You, Jaime Feliu Batlle, Hal Galbraith, John Sarantopoulos, Suresh S. Ramalingam, Helen Mann, Karen So, Martin Johnson and Karthick Vishwanathan
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 291-299; DOI: https://doi.org/10.1124/jpet.118.255919

Neuropharmacology

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    Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane
    Cheng Zhou, Kenneth W. Johnson, Karl F. Herold and Hugh C. Hemmings
    Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 200-211; DOI: https://doi.org/10.1124/jpet.118.254938
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 369 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 369, Issue 2
1 May 2019
  • Table of Contents
  • Table of Contents (PDF)
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  • Minireviews
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  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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