Journal of Pharmacology and Experimental Therapeutics: 369 (1)

April 01, 2019; Volume 369,Issue 1

Behavioral Pharmacology

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Targeting Dopamine D₂, Adenosine A_2A, and Glutamate mGlu₅ Receptors to Reduce Repetitive Behaviors in Deer Mice
Mark H. Lewis, Christopher T. Primiani and Amber M. Muehlmann

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 88-97; DOI: https://doi.org/10.1124/jpet.118.256081
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N-Palmitoylethanolamide Exerts Antidepressant-Like Effects in Rats: Involvement of PPARα Pathway in the Hippocampus
Miaomiao Li, Dan Wang, Wenpeng Bi, Zheng-er Jiang, Rilong Piao and Hailing Yu

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 163-172; DOI: https://doi.org/10.1124/jpet.118.254524

Cardiovascular

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Regulation of the β-Adrenergic Receptor Signaling Pathway in Sustained Ligand-Activated Preconditioning
L. E. See Hoe, S. R. Foster, L. Wendt, H. H. Patel, J. P. Headrick and J. N. Peart

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 37-46; DOI: https://doi.org/10.1124/jpet.118.251660
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Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury
James Boslett, Nikhil Reddy, Yasmin A. Alzarie and Jay L. Zweier

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 55-64; DOI: https://doi.org/10.1124/jpet.118.254557
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Initial Characterization of Transgenic Mice Overexpressing Human Histamine H₂ Receptors
U. Gergs, G. Bernhardt, I. B. Buchwalow, H. Edler, J. Fröba, M. Keller, U. Kirchhefer, F. Köhler, N. Mißlinger, H. Wache and J. Neumann

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 129-141; DOI: https://doi.org/10.1124/jpet.118.255711
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Proximal Tubule β₂-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury
Robert B. Cameron, Whitney S. Gibbs, Siennah R. Miller, Tess V. Dupre, Judit Megyesi, Craig C. Beeson and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 173-180; DOI: https://doi.org/10.1124/jpet.118.252833

Cellular and Molecular

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Facilitation of Chemotaxis Activity of Mesenchymal Stem Cells via Stromal Cell–Derived Factor-1 and Its Receptor May Promote Ectopic Ossification of Human Spinal Ligaments
Shunfu Chin, Ken-Ichi Furukawa, Keigo Kurotaki, Shunpei Nagasaki, Kanichiro Wada, Gentaro Kumagai, Shigeru Motomura and Yasuyuki Ishibashi

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 1-8; DOI: https://doi.org/10.1124/jpet.118.254367
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Contractile Effects of Serotonin (5-HT) in the Rat Cauda Epididymis: Expression and Functional Characterization of 5-HT Receptors
Andre Mueller, Luiz R. A. Kiguti, Erick J. R. Silva and André S. Pupo

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 98-106; DOI: https://doi.org/10.1124/jpet.118.254110
Open Access
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Marta Reyes-Corral, Naja M. Sørensen, Christopher Thrasivoulou, Prokar Dasgupta, Jonathan F. Ashmore and Aamir Ahmed

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 152-162; DOI: https://doi.org/10.1124/jpet.118.254375

Drug Discovery and Translational Medicine

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A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction
Meredith Hay, Robin Polt, Michael L. Heien, Todd W. Vanderah, Tally M. Largent-Milnes, Kathleen Rodgers, Torsten Falk, Mitchell J. Bartlett, Kristian P. Doyle and John P. Konhilas

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 9-25; DOI: https://doi.org/10.1124/jpet.118.254854
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Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide
Cristina Moldovan Loomis, Benjamin Dutzar, Ethan W. Ojala, Lee Hendrix, Charlie Karasek, Michelle Scalley-Kim, Jenny Mulligan, Pei Fan, Jens Billgren, Vanessa Rubin, Heidi Boshaw, Gayle Kwon, Sam Marzolf, Erica Stewart, David Jurchen, Susan M. Pederson, Lisa Perrino McCulloch, Brian Baker, Roger K. Cady, John A. Latham, Dan Allison and Leon F. Garcia-Martinez

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 26-36; DOI: https://doi.org/10.1124/jpet.118.253443
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Ferroptosis as a Novel Therapeutic Target for Friedreich’s Ataxia
M. Grazia Cotticelli, Shujuan Xia, Daniel Lin, Taehee Lee, Leila Terrab, Peter Wipf, Donna M. Huryn and Robert B. Wilson

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 47-54; DOI: https://doi.org/10.1124/jpet.118.252759
Open Access
Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug?
Marie Rouquette, Sinda Lepetre-Mouelhi, Ophélie Dufrançais, Xue Yang, Julie Mougin, Grégory Pieters, Sébastien Garcia-Argote, Adriaan P. IJzerman and Patrick Couvreur

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 144-151; DOI: https://doi.org/10.1124/jpet.118.254961

Gastrointestinal, Hepatic, Pulmonary, and Renal

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RLA8—A New and Highly Effective Quadruple PPAR-α/γ/δ and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis
Meng Hua Li, Wei Chen, Li Li Wang, Jia Lin Sun, Lei Zhou, Yu Cong Shi, Chu Han Wang, Bo Hua Zhong, Wei Guo Shi and Zhong Wu Guo

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 67-77; DOI: https://doi.org/10.1124/jpet.118.255216

Neuropharmacology

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Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats
Ryosuke Shimizu, Naotaka Horiguchi, Koji Yano, Masashi Sakuramoto, Naoki Kanegawa, Shunji Shinohara and Shuichi Ohnishi

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 78-87; DOI: https://doi.org/10.1124/jpet.118.252262
Open Access
Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine
Marcel M. van Gaalen, Christina Schlumbohm, Joost H. Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach and Robert E. Stratford

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 107-120; DOI: https://doi.org/10.1124/jpet.118.254508
Open Access
Icariin Delays Brain Aging in Senescence-Accelerated Mouse Prone 8 (SAMP8) Model via Inhibiting Autophagy
Fa-Ju Chen, Bo Liu, Qin Wu, Jie Liu, Yun-Yan Xu, Shao-Yu Zhou and Jing-Shan Shi

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 121-128; DOI: https://doi.org/10.1124/jpet.118.253310

Errata

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Correction to “ß Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves ß2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia”
Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 65; DOI: https://doi.org/10.1124/jpet.115.228411err
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Correction to “Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson’s Disease”
Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 66; DOI: https://doi.org/10.1124/jpet.112.201558err
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Correction to “Orally Active Opioid µ/d Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice”
Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 142; DOI: https://doi.org/10.1124/jpet.112.208108err
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Correction to “Regulation of d Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid–Dependent 12/15-Lipoxygenase Metabolites”
Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 143; DOI: https://doi.org/10.1124/jpet.112.241604err
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Correction to “Synergistic Effects of Acetyl-l-Carnitine and Adipose-Derived Stromal Cells on Improving Regenerative Capacity of Acellular Nerve Allograft in Sciatic Nerve Defect”
Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 181; DOI: https://doi.org/10.1124/jpet.118.254540err

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Table of Contents

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Neuropharmacology

Errata

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