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Research ArticleCardiovascular

Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats

Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada and Tetsuji Miura
Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 524-534; DOI: https://doi.org/10.1124/jpet.118.253666
Hiroto Oshima
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Takayuki Miki
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Atsushi Kuno
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Masashi Mizuno
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Tatsuya Sato
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Masaya Tanno
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Toshiyuki Yano
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Kei Nakata
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Yukishige Kimura
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Koki Abe
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Wataru Ohwada
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Tetsuji Miura
Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
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Article Information

vol. 368 no. 3 524-534
DOI 
https://doi.org/10.1124/jpet.118.253666
PubMed 
30552292

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 14, 2018
  • Accepted December 10, 2018
  • Published online February 19, 2019.

Article Versions

  • Earlier version (December 14, 2018 - 08:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hiroto Oshima,
  2. Takayuki Miki,
  3. Atsushi Kuno,
  4. Masashi Mizuno,
  5. Tatsuya Sato,
  6. Masaya Tanno,
  7. Toshiyuki Yano,
  8. Kei Nakata,
  9. Yukishige Kimura,
  10. Koki Abe,
  11. Wataru Ohwada, and
  12. Tetsuji Miura
  1. Departments of Cardiovascular, Renal and Metabolic Medicine (H.O., Ta.M., A.K., M.M., T.S., M.T., T.Y., K.N., Y.K., K.A., W.O., Te.M.), Pharmacology (A.K.), and Cellular Physiology and Signal Transduction (T.S.), Sapporo Medical University School of Medicine, Sapporo, Japan
  1. Address correspondence to:
    Dr. Tetsuji Miura, Department of Cardiovascular, Renal, and Metabolic Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan. E-mail: miura{at}sapmed.ac.jp
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Journal of Pharmacology and Experimental Therapeutics: 368 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 368, Issue 3
1 Mar 2019
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Research ArticleCardiovascular

SGLT2 Inhibitor and Cardioprotection

Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada and Tetsuji Miura
Journal of Pharmacology and Experimental Therapeutics March 1, 2019, 368 (3) 524-534; DOI: https://doi.org/10.1124/jpet.118.253666

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Research ArticleCardiovascular

SGLT2 Inhibitor and Cardioprotection

Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada and Tetsuji Miura
Journal of Pharmacology and Experimental Therapeutics March 1, 2019, 368 (3) 524-534; DOI: https://doi.org/10.1124/jpet.118.253666
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