Journal of Pharmacology and Experimental Therapeutics: 368 (3)

March 01, 2019; Volume 368,Issue 3

Cardiovascular

Open Access
Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension
Frederic Trensz, Céline Bortolamiol, Markus Kramberg, Daniel Wanner, Hakim Hadana, Markus Rey, Daniel S. Strasser, Stéphane Delahaye, Patrick Hess, Enrico Vezzali, Ulrich Mentzel, Joël Ménard, Martine Clozel and Marc Iglarz

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 462-473; DOI: https://doi.org/10.1124/jpet.118.253864
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Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats
Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada and Tetsuji Miura

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 524-534; DOI: https://doi.org/10.1124/jpet.118.253666

Cellular and Molecular

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Synthetic Cannabinoid Hydroxypentyl Metabolites Retain Efficacy at Human Cannabinoid Receptors
Thomas F. Gamage, Charlotte E. Farquhar, Ryan J. McKinnie, Richard C. Kevin, Iain S. McGregor, Mark L. Trudell, Jenny L. Wiley and Brian F. Thomas

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 414-422; DOI: https://doi.org/10.1124/jpet.118.254425
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Endothelial Cell–Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue
Taro E. Akiyama, Graham E. Skelhorne-Gross, Elizabeth D. Lightbody, Rachel E. Rubino, Jia Yue Shi, Lesley A. McNamara, Neelam Sharma, Emanuel I. Zycband, Frank J. Gonzalez, Haiying Liu, John W. Woods, C. H. Chang, Joel P. Berger and Christopher J. B. Nicol

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 514-523; DOI: https://doi.org/10.1124/jpet.118.250985

Drug Discovery and Translational Medicine

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Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer
Honglin Tang, Yanzhuo Liu, Chenlong Wang, Hao Zheng, Yaxin Chen, Wen Liu, Xuewei Chen, Jing Zhang, Honglei Chen, Yuqing Yang and Jing Yang

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 401-413; DOI: https://doi.org/10.1124/jpet.118.254359
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LCAT Enzyme Replacement Therapy Reduces LpX and Improves Kidney Function in a Mouse Model of Familial LCAT Deficiency
Boris L. Vaisman, Edward B. Neufeld, Lita A. Freeman, Scott M. Gordon, Maureen L. Sampson, Milton Pryor, Emily Hillman, Milton J. Axley, Sotirios K. Karathanasis and Alan T. Remaley

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 423-434; DOI: https://doi.org/10.1124/jpet.118.251876
Open Access
Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle
Roselyne Castonguay, Jennifer Lachey, Samantha Wallner, Jamie Strand, Katia Liharska, Abigail E. Watanabe, Marishka Cannell, Monique V. Davies, Dianne Sako, Megan E. Troy, Lavanya Krishnan, Aaron W. Mulivor, Huiming Li, Sarah Keates, Mark J. Alexander, R. Scott Pearsall and Ravi Kumar

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 435-445; DOI: https://doi.org/10.1124/jpet.118.252304

Inflammation, Immunopharmacology, and Asthma

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Cinobufacini Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization
Si-wei Wang, Yong-feng Bai, Yuan-yuan Weng, Xue-yu Fan, Hui Huang, Fang Zheng, Yi Xu and Feng Zhang

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 391-400; DOI: https://doi.org/10.1124/jpet.118.254516
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Antibody Dependent Enhancement of Acinetobacter baumannii Infection in a Mouse Pneumonia Model
Shun Xin Wang-Lin, Ruth Olson, Janet M. Beanan, Ulrike MacDonald, Thomas A. Russo and Joseph P. Balthasar

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 475-489; DOI: https://doi.org/10.1124/jpet.118.253617

Metabolism, Transport, and Pharmacogenomics

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The HNF1α-Regulated LncRNA HNF1α-AS1 Is Involved in the Regulation of Cytochrome P450 Expression in Human Liver Tissues and Huh7 Cells
Yiting Wang, Liang Yan, Jingyang Liu, Shitong Chen, Guangming Liu, Yali Nie, Pei Wang, Weihong Yang, Liming Chen, Xiaobo Zhong, Shengna Han and Lirong Zhang

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 353-362; DOI: https://doi.org/10.1124/jpet.118.252940
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Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma
Dong Gui Hu, Shashikanth Marri, Ross A. McKinnon, Peter I. Mackenzie and Robyn Meech

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 363-381; DOI: https://doi.org/10.1124/jpet.118.255018
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Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases
Gautham Gampa, Minjee Kim, Afroz S. Mohammad, Karen E. Parrish, Ann C. Mladek, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 446-461; DOI: https://doi.org/10.1124/jpet.118.253708
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Measurement and Quantitative Characterization of Whole-Body Pharmacokinetics of Exogenously Administered T Cells in Mice
Antari Khot, Satoko Matsueda, Veena A. Thomas, Richard C. Koya and Dhaval K. Shah

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 503-513; DOI: https://doi.org/10.1124/jpet.118.252858

Neuropharmacology

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Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine–Induced Status Epilepticus in Rats: Comparison with Allopregnanolone
Michael S. Saporito, John A. Gruner, Amy DiCamillo, Richard Hinchliffe, Melissa Barker-Haliski and H. Steven White

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 326-337; DOI: https://doi.org/10.1124/jpet.118.252155
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Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury
Asit Kumar, Rebecca J. Henry, Bogdan A. Stoica, David J. Loane, Gelareh Abulwerdi, Shahnawaz A. Bhat and Alan I. Faden

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 338-352; DOI: https://doi.org/10.1124/jpet.118.253955
Open Access
In Vivo Preclinical Molecular Imaging of Repeated Exposure to an N-methyl-d-aspartate Antagonist and a Glutaminase Inhibitor as Potential Glutamatergic Modulators
Stijn Servaes, Firat Kara, Dorien Glorie, Sigrid Stroobants, Annemie Van Der Linden and Steven Staelens

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 382-390; DOI: https://doi.org/10.1124/jpet.118.252635
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Synergistic Effects of Acetyl-l-Carnitine and Adipose-Derived Stromal Cells on Improving Regenerative Capacity of Acellular Nerve Allograft in Sciatic Nerve Defect
Ghayour Mohammad-Bagher, Abdolmaleki Arash, Behnam-Rassouli Morteza, Mahdavi-Shahri Naser and Moghimi Ali

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 490-502; DOI: https://doi.org/10.1124/jpet.118.254540
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Inflammatory Macrophages in the Sciatic Nerves Facilitate Neuropathic Pain Associated with Type 2 Diabetes Mellitus
Fumihiro Saika, Norikazu Kiguchi, Shinsuke Matsuzaki, Daichi Kobayashi and Shiroh Kishioka

Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 535-544; DOI: https://doi.org/10.1124/jpet.118.252668

Erratum

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Correction to “Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance”
Journal of Pharmacology and Experimental Therapeutics March 2019, 368 (3) 474; DOI: https://doi.org/10.1124/jpet.117.251413err

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Table of Contents

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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