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Research ArticleDrug Discovery and Translational Medicine

Development of Human Target Validation Classification that Predicts Future Clinical Efficacy

Cecilia Karlsson, Peter J. Greasley, David Gustafsson and Karin Wåhlander
Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 255-261; DOI: https://doi.org/10.1124/jpet.118.250894
Cecilia Karlsson
Cardiovascular, Renal and Metabolism Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden (C.K., P.J.G.); Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (C.K.); Emeriti Pharma, AZ Bioventure Hub, Gothenburg, Sweden (D.G.); and KW Translational Medicine AB, Västra Frölunda, Sweden (K.W.)
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Peter J. Greasley
Cardiovascular, Renal and Metabolism Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden (C.K., P.J.G.); Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (C.K.); Emeriti Pharma, AZ Bioventure Hub, Gothenburg, Sweden (D.G.); and KW Translational Medicine AB, Västra Frölunda, Sweden (K.W.)
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David Gustafsson
Cardiovascular, Renal and Metabolism Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden (C.K., P.J.G.); Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (C.K.); Emeriti Pharma, AZ Bioventure Hub, Gothenburg, Sweden (D.G.); and KW Translational Medicine AB, Västra Frölunda, Sweden (K.W.)
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Karin Wåhlander
Cardiovascular, Renal and Metabolism Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden (C.K., P.J.G.); Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (C.K.); Emeriti Pharma, AZ Bioventure Hub, Gothenburg, Sweden (D.G.); and KW Translational Medicine AB, Västra Frölunda, Sweden (K.W.)
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Article Information

vol. 368 no. 2 255-261
DOI 
https://doi.org/10.1124/jpet.118.250894
PubMed 
30482795

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 24, 2018
  • Accepted November 13, 2018
  • Published online January 17, 2019.

Article Versions

  • Earlier version (November 27, 2018 - 07:44).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cecilia Karlsson,
  2. Peter J. Greasley,
  3. David Gustafsson, and
  4. Karin Wåhlander
  1. Cardiovascular, Renal and Metabolism Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden (C.K., P.J.G.); Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (C.K.); Emeriti Pharma, AZ Bioventure Hub, Gothenburg, Sweden (D.G.); and KW Translational Medicine AB, Västra Frölunda, Sweden (K.W.)
  1. Address correspondence to:
    Dr. Cecilia Karlsson, Cardiovascular, Renal and Metabolism Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca Gothenburg, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. E-mail: cecilia.karlsson{at}astrazeneca.com
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Journal of Pharmacology and Experimental Therapeutics: 368 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 368, Issue 2
1 Feb 2019
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Research ArticleDrug Discovery and Translational Medicine

Human Target Validation Classification Predicts Efficacy

Cecilia Karlsson, Peter J. Greasley, David Gustafsson and Karin Wåhlander
Journal of Pharmacology and Experimental Therapeutics February 1, 2019, 368 (2) 255-261; DOI: https://doi.org/10.1124/jpet.118.250894

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Research ArticleDrug Discovery and Translational Medicine

Human Target Validation Classification Predicts Efficacy

Cecilia Karlsson, Peter J. Greasley, David Gustafsson and Karin Wåhlander
Journal of Pharmacology and Experimental Therapeutics February 1, 2019, 368 (2) 255-261; DOI: https://doi.org/10.1124/jpet.118.250894
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