Journal of Pharmacology and Experimental Therapeutics: 368 (2)

February 01, 2019; Volume 368,Issue 2

Minireviews

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Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs
Yosuke Hashimoto, Yoshiaki Okada, Keisuke Shirakura, Keisuke Tachibana, Makoto Sawada, Kiyohito Yagi, Takefumi Doi and Masuo Kondoh

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 179-186; DOI: https://doi.org/10.1124/jpet.118.252361

Behavioral Pharmacology

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Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice
Catheryn D. Wilson, Sherrica Tai, Laura Ewing, Jasmine Crane, Taylor Lockhart, Ryochi Fujiwara, Anna Radominska-Pandya and William E. Fantegrossi

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 146-156; DOI: https://doi.org/10.1124/jpet.118.251157
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Reversal and Prevention of the Respiratory-Depressant Effects of Heroin by the Novel μ-Opioid Receptor Antagonist Methocinnamox in Rhesus Monkeys
Lisa R. Gerak, David R. Maguire, James H. Woods, Stephen M. Husbands, Alex Disney and Charles P. France

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 229-236; DOI: https://doi.org/10.1124/jpet.118.253286

Cardiovascular

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Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition
Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori and Shunichi Shimizu

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 246-254; DOI: https://doi.org/10.1124/jpet.118.253922

Cellular and Molecular

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Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives
Hilary E. Nicholson, Walid F. Alsharif, Anthony B. Comeau, Christophe Mesangeau, Sebastiano Intagliata, Marco Mottinelli, Christopher R. McCurdy and Wayne D. Bowen

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 272-281; DOI: https://doi.org/10.1124/jpet.118.253484

Drug Discovery and Translational Medicine

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Development of Human Target Validation Classification that Predicts Future Clinical Efficacy
Cecilia Karlsson, Peter J. Greasley, David Gustafsson and Karin Wåhlander

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 255-261; DOI: https://doi.org/10.1124/jpet.118.250894
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A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats
Michael D. Raleigh, Federico Baruffaldi, Samantha J. Peterson, Morgan Le Naour, Theresa M. Harmon, Jennifer R. Vigliaturo, Paul R. Pentel and Marco Pravetoni

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 282-291; DOI: https://doi.org/10.1124/jpet.118.253674

Endocrine and Diabetes

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Estrogen-Dependent Disruption of Adiponectin-Connexin43 Signaling Underlies Exacerbated Myocardial Dysfunction in Diabetic Female Rats
Korin E. Leffler and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 208-217; DOI: https://doi.org/10.1124/jpet.118.254029
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α-Tocopherol Potentiates the Cervical Resistance Decreasing Effects of COX Inhibitors in Pregnant Rats: The Putative Role of Cyclooxygenase-2 Inhibition
Anna Kothencz, Judit Hajagos-Tóth, Kálmán F. Szűcs, Annamária Schaffer and Róbert Gáspár

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 292-298; DOI: https://doi.org/10.1124/jpet.118.251850

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Diuretic, Natriuretic, and Vasodepressor Activity of a Lipid Fraction Enhanced in Medium of Cultured Mouse Medullary Interstitial Cells by a Selective Fatty Acid Amide Hydrolase Inhibitor
Zdravka Daneva, Sara K. Dempsey, Ashfaq Ahmad, Ningjun Li, Pin-Lan Li and Joseph K. Ritter

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 187-198; DOI: https://doi.org/10.1124/jpet.118.252320
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Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity
John P. Russell, Ehsan Mohammadi, Casey O. Ligon, Anthony C. Johnson, Michael D. Gershon, Meenakshi Rao, Yuhong Shen, Chi-Chung Chan, Hilary S. Eidam, Michael P. DeMartino, Mui Cheung, Allen I. Oliff, Sanjay Kumar and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 299-307; DOI: https://doi.org/10.1124/jpet.118.252973

Inflammation, Immunopharmacology, and Asthma

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Nicotine Modulates Growth Factors and MicroRNA to Promote Inflammatory and Fibrotic Processes
Afshin Ebrahimpour, Samana Shrestha, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu and Yohannes T. Ghebre

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 169-178; DOI: https://doi.org/10.1124/jpet.118.252650
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Dihydromyricetin Inhibits Inflammation of Fibroblast-Like Synoviocytes through Regulation of Nuclear Factor-κB Signaling in Rats with Collagen-Induced Arthritis
Jing Wu, Fu-Tao Zhao, Kai-Jian Fan, Jun Zhang, Bing-Xing Xu, Qi-Shan Wang, Ting-Ting Tang and Ting-Yu Wang

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 218-228; DOI: https://doi.org/10.1124/jpet.118.253369

Metabolism, Transport, and Pharmacogenomics

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Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance
Takanobu Matsuzaki, Daniel Scotcher, Adam S. Darwich, Aleksandra Galetin and Amin Rostami-Hodjegan

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 157-168; DOI: https://doi.org/10.1124/jpet.118.251413
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Alterations in Xenobiotic-Metabolizing Enzyme Activities across Menstrual Cycle in Healthy Volunteers
E. Asprodini, V. Tsiokou, E. Begas, T. Kilindris, E. Kouvaras, M. Samara and I. Messinis

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 262-271; DOI: https://doi.org/10.1124/jpet.118.254284
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Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol
Aaron M. Teitelbaum, Matthew G. McDonald, John P. Kowalski, Oliver T. Parkinson, Michele Scian, Dale Whittington, Katharina Roellecke, Helmut Hanenberg, Constanze Wiek and Allan E. Rettie

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 308-316; DOI: https://doi.org/10.1124/jpet.118.249771
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Experimental Evidence for Resecretion of PGE₂ across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport
Takeo Nakanishi, Hiroki Takashima, Yuka Uetoko, Hisakazu Komori and Ikumi Tamai

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 317-325; DOI: https://doi.org/10.1124/jpet.118.249789

Neuropharmacology

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A Comparative Study of the Pharmacokinetics of Clozapine N-Oxide and Clozapine N-Oxide Hydrochloride Salt in Rhesus Macaques
Daicia C. Allen, Timothy L. Carlson, Yan Xiong, Jian Jin, Kathleen A. Grant and Verginia C. Cuzon Carlson

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 199-207; DOI: https://doi.org/10.1124/jpet.118.252031
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Inhibitory Effects of Mas-Related Gene C Receptor on Chronic Morphine-Induced Spinal Glial Activation in Rats
Yunshan Zhang, Mei Wang, Qiuhua Lu, Qi Li, Mingyan Lin, Jianzhong Huang and Yanguo Hong

Journal of Pharmacology and Experimental Therapeutics February 2019, 368 (2) 237-245; DOI: https://doi.org/10.1124/jpet.118.252494

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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