Journal of Pharmacology and Experimental Therapeutics: 367 (3)

December 01, 2018; Volume 367,Issue 3

Behavioral Pharmacology

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Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats
Saadet Inan, Toby K. Eisenstein, Mia N. Watson, Menahem Doura, Joseph J. Meissler, Christopher S. Tallarida, Xiaohong Chen, Ellen B. Geller, Scott M. Rawls, Alan Cowan and Martin W. Adler

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 433-441; DOI: https://doi.org/10.1124/jpet.118.252890

Cardiovascular

Open Access
Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice
Wen-Liang Song, Emanuela Ricciotti, Xue Liang, Tilo Grosser, Gregory R. Grant and Garret A. FitzGerald

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 425-432; DOI: https://doi.org/10.1124/jpet.118.250936
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The Endogenous Lusitropic and Chronotropic Agent, B-Type Natriuretic Peptide, Limits Cardiac Troponin Release in Cancer Patients with an Early Impairment of Myocardial Relaxation Induced by Anthracyclines
Pierantonio Menna, Emanuela Salvatorelli, Grazia Armento, Ombretta Annibali, Carlo Greco, Francesco Marchesi, Vito Calabrese, Giorgio Reggiardo and Giorgio Minotti

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 518-527; DOI: https://doi.org/10.1124/jpet.118.253104

Drug Discovery and Translational Medicine

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Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice
Philippe B. Pierrillas, Emilie Henin, Julien Ogier, Laurence Kraus-Berthier, Marylore Chenel, François Bouzom and Michel Tod

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 414-424; DOI: https://doi.org/10.1124/jpet.118.251694
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Targeting Canine KIT Promoter by Candidate DNA G-Quadruplex Ligands
Eleonora Zorzan, Silvia Da Ros, Mery Giantin, Lara Zorro Shahidian, Giorgia Guerra, Manlio Palumbo, Claudia Sissi and Mauro Dacasto

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 461-472; DOI: https://doi.org/10.1124/jpet.118.248997
Open Access
Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators
Jason R. Clapper, Cassandra L. Henry, Micah J. Niphakis, Anna M. Knize, Aundrea R. Coppola, Gabriel M. Simon, Nhi Ngo, Rachel A. Herbst, Dylan M. Herbst, Alex W. Reed, Justin S. Cisar, Olivia D. Weber, Andreu Viader, Jessica P. Alexander, Mark L. Cunningham, Todd K. Jones, Iain P. Fraser, Cheryl A. Grice, R. Alan B. Ezekowitz, Gary P. O’Neill and Jacqueline L. Blankman

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 494-508; DOI: https://doi.org/10.1124/jpet.118.252296
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DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats
Koji Matsumoto, Tomomi Yoshitomi, Yoko Ishimoto, Naomi Tanaka, Kanako Takahashi, Akiko Watanabe and Katsuyoshi Chiba

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 509-517; DOI: https://doi.org/10.1124/jpet.118.250019

Gastrointestinal, Hepatic, Pulmonary, and Renal

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The Phosphate Binder Ferric Citrate Alters the Gut Microbiome in Rats with Chronic Kidney Disease
Wei Ling Lau, Nosratola D. Vaziri, Ane C. F. Nunes, André M. Comeau, Morgan G. I. Langille, Whitney England, Mahyar Khazaeli, Yasunori Suematsu, Joann Phan and Katrine Whiteson

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 452-460; DOI: https://doi.org/10.1124/jpet.118.251389

Inflammation, Immunopharmacology, and Asthma

Open Access
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma
Sanjeev Khindri, Anthony Cahn, Malcolm Begg, Mickael Montembault, Claudia Leemereise, Yi Cui, Annabel Hogg, Hannah Wajdner, Shuying Yang, Jon Robertson, J. Nicole Hamblin, Andrea Ludwig-Sengpiel, Oliver Kornmann and Edith M. Hessel

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 405-413; DOI: https://doi.org/10.1124/jpet.118.249516
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Glucocorticoid-Induced Leucine Zipper Promotes Neutrophil and T-Cell Polarization with Protective Effects in Acute Kidney Injury
Babak Baban, Cristina Marchetti, Hesam Khodadadi, Aneeq Malik, Golnaz Emami, Ping-Chang Lin, Ali S. Arbab, Carlo Riccardi and Mahmood S. Mozaffari

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 483-493; DOI: https://doi.org/10.1124/jpet.118.251371

Metabolism, Transport, and Pharmacogenomics

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Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis
Na Gao, Jing Li, Ming-Rui Li, Bing Qi, Zhao Wang, Gao-Ju Wang, Jie Gao and Hai-Ling Qiao

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 473-482; DOI: https://doi.org/10.1124/jpet.118.249425

Neuropharmacology

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Sex Differences in the Pharmacokinetics of Low-dose Ketamine in Plasma and Brain of Male and Female Rats
Samantha K. Saland and Mohamed Kabbaj

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 393-404; DOI: https://doi.org/10.1124/jpet.118.251652
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Safinamide Modulates Striatal Glutamatergic Signaling in a Rat Model of Levodopa-Induced Dyskinesia
F. Gardoni, M. Morari, J. Kulisevsky, A. Brugnoli, S. Novello, C. A. Pisanò, C. Caccia, M. Mellone, E. Melloni, G. Padoani, V. Sosti, S. Vailati and C. Keywood

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 442-451; DOI: https://doi.org/10.1124/jpet.118.251645
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Celecoxib Treatment Improves Neurologic Deficit and Reduces Selective Neuronal Loss and Glial Response in Rats after Transient Middle Cerebral Artery Occlusion
María Santos-Galdiano, Diego Pérez-Rodríguez, Berta Anuncibay-Soto, Enrique Font-Belmonte, Irene F. Ugidos, Carlos César Pérez-García and Arsenio Fernández-López

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 528-542; DOI: https://doi.org/10.1124/jpet.118.251264
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Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats
Jeremy Carlier, Ariane Wohlfarth, Bonita D. Salmeron, Karl B. Scheidweiler, Marilyn A. Huestis and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 543-550; DOI: https://doi.org/10.1124/jpet.118.250530
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Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit
Richard A. Slivicki, Shahin A. Saberi, Vishakh Iyer, V. Kiran Vemuri, Alexandros Makriyannis and Andrea G. Hohmann

Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 551-563; DOI: https://doi.org/10.1124/jpet.118.252288

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Table of Contents

Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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