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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 2018; Volume 367,Issue 3

Behavioral Pharmacology

  • You have access
    Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats
    Saadet Inan, Toby K. Eisenstein, Mia N. Watson, Menahem Doura, Joseph J. Meissler, Christopher S. Tallarida, Xiaohong Chen, Ellen B. Geller, Scott M. Rawls, Alan Cowan and Martin W. Adler
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 433-441; DOI: https://doi.org/10.1124/jpet.118.252890

Cardiovascular

  • Open Access
    Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice
    Wen-Liang Song, Emanuela Ricciotti, Xue Liang, Tilo Grosser, Gregory R. Grant and Garret A. FitzGerald
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 425-432; DOI: https://doi.org/10.1124/jpet.118.250936
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    The Endogenous Lusitropic and Chronotropic Agent, B-Type Natriuretic Peptide, Limits Cardiac Troponin Release in Cancer Patients with an Early Impairment of Myocardial Relaxation Induced by Anthracyclines
    Pierantonio Menna, Emanuela Salvatorelli, Grazia Armento, Ombretta Annibali, Carlo Greco, Francesco Marchesi, Vito Calabrese, Giorgio Reggiardo and Giorgio Minotti
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 518-527; DOI: https://doi.org/10.1124/jpet.118.253104

Drug Discovery and Translational Medicine

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    Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice
    Philippe B. Pierrillas, Emilie Henin, Julien Ogier, Laurence Kraus-Berthier, Marylore Chenel, François Bouzom and Michel Tod
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 414-424; DOI: https://doi.org/10.1124/jpet.118.251694
  • Targeting Canine <em>KIT</em> Promoter by Candidate DNA G-Quadruplex Ligands
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    Targeting Canine KIT Promoter by Candidate DNA G-Quadruplex Ligands
    Eleonora Zorzan, Silvia Da Ros, Mery Giantin, Lara Zorro Shahidian, Giorgia Guerra, Manlio Palumbo, Claudia Sissi and Mauro Dacasto
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 461-472; DOI: https://doi.org/10.1124/jpet.118.248997
  • Open Access
    Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators
    Jason R. Clapper, Cassandra L. Henry, Micah J. Niphakis, Anna M. Knize, Aundrea R. Coppola, Gabriel M. Simon, Nhi Ngo, Rachel A. Herbst, Dylan M. Herbst, Alex W. Reed, Justin S. Cisar, Olivia D. Weber, Andreu Viader, Jessica P. Alexander, Mark L. Cunningham, Todd K. Jones, Iain P. Fraser, Cheryl A. Grice, R. Alan B. Ezekowitz, Gary P. O’Neill and Jacqueline L. Blankman
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 494-508; DOI: https://doi.org/10.1124/jpet.118.252296
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    DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats
    Koji Matsumoto, Tomomi Yoshitomi, Yoko Ishimoto, Naomi Tanaka, Kanako Takahashi, Akiko Watanabe and Katsuyoshi Chiba
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 509-517; DOI: https://doi.org/10.1124/jpet.118.250019

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    The Phosphate Binder Ferric Citrate Alters the Gut Microbiome in Rats with Chronic Kidney Disease
    Wei Ling Lau, Nosratola D. Vaziri, Ane C. F. Nunes, André M. Comeau, Morgan G. I. Langille, Whitney England, Mahyar Khazaeli, Yasunori Suematsu, Joann Phan and Katrine Whiteson
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 452-460; DOI: https://doi.org/10.1124/jpet.118.251389

Inflammation, Immunopharmacology, and Asthma

  • Open Access
    A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma
    Sanjeev Khindri, Anthony Cahn, Malcolm Begg, Mickael Montembault, Claudia Leemereise, Yi Cui, Annabel Hogg, Hannah Wajdner, Shuying Yang, Jon Robertson, J. Nicole Hamblin, Andrea Ludwig-Sengpiel, Oliver Kornmann and Edith M. Hessel
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 405-413; DOI: https://doi.org/10.1124/jpet.118.249516
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    Glucocorticoid-Induced Leucine Zipper Promotes Neutrophil and T-Cell Polarization with Protective Effects in Acute Kidney Injury
    Babak Baban, Cristina Marchetti, Hesam Khodadadi, Aneeq Malik, Golnaz Emami, Ping-Chang Lin, Ali S. Arbab, Carlo Riccardi and Mahmood S. Mozaffari
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 483-493; DOI: https://doi.org/10.1124/jpet.118.251371

Metabolism, Transport, and Pharmacogenomics

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    Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis
    Na Gao, Jing Li, Ming-Rui Li, Bing Qi, Zhao Wang, Gao-Ju Wang, Jie Gao and Hai-Ling Qiao
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 473-482; DOI: https://doi.org/10.1124/jpet.118.249425

Neuropharmacology

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    Sex Differences in the Pharmacokinetics of Low-dose Ketamine in Plasma and Brain of Male and Female Rats
    Samantha K. Saland and Mohamed Kabbaj
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 393-404; DOI: https://doi.org/10.1124/jpet.118.251652
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    Safinamide Modulates Striatal Glutamatergic Signaling in a Rat Model of Levodopa-Induced Dyskinesia
    F. Gardoni, M. Morari, J. Kulisevsky, A. Brugnoli, S. Novello, C. A. Pisanò, C. Caccia, M. Mellone, E. Melloni, G. Padoani, V. Sosti, S. Vailati and C. Keywood
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 442-451; DOI: https://doi.org/10.1124/jpet.118.251645
  • Celecoxib Treatment Improves Neurologic Deficit and Reduces Selective Neuronal Loss and Glial Response in Rats after Transient Middle Cerebral Artery Occlusion
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    Celecoxib Treatment Improves Neurologic Deficit and Reduces Selective Neuronal Loss and Glial Response in Rats after Transient Middle Cerebral Artery Occlusion
    María Santos-Galdiano, Diego Pérez-Rodríguez, Berta Anuncibay-Soto, Enrique Font-Belmonte, Irene F. Ugidos, Carlos César Pérez-García and Arsenio Fernández-López
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 528-542; DOI: https://doi.org/10.1124/jpet.118.251264
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    Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats
    Jeremy Carlier, Ariane Wohlfarth, Bonita D. Salmeron, Karl B. Scheidweiler, Marilyn A. Huestis and Michael H. Baumann
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 543-550; DOI: https://doi.org/10.1124/jpet.118.250530
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    Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit
    Richard A. Slivicki, Shahin A. Saberi, Vishakh Iyer, V. Kiran Vemuri, Alexandros Makriyannis and Andrea G. Hohmann
    Journal of Pharmacology and Experimental Therapeutics December 2018, 367 (3) 551-563; DOI: https://doi.org/10.1124/jpet.118.252288
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Journal of Pharmacology and Experimental Therapeutics: 367 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 367, Issue 3
1 Dec 2018
  • Table of Contents
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  • Behavioral Pharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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