Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Supplemental Table 1 - LC‐MS/MS conditions for sample analysis in metabolism studies
Supplemental Figure 1 - Schematic of the step-wise approach employed in evaluating the clearance mechanism of high permeabilitylow molecular weight acid and zwitterion drugs (ECCS class 1A)
Supplemental Figure 2 - Comparison of intrinsic clearance measured by substrate-depletion in pooled human liver microsomes and pooled human hepatocytes
Supplemental Figure 3 - Observed versus predicted clearance of the 4 OAT2/OATP1B1 dual substrates assuming an empirical scaling factor of 10.6 (Varma et al., 2014) for the active hepatic uptake (PSactive) in the extended clearance model (Eq. 10)
Supplemental Figure 4 - Comparison of apparent transcellular permeability (Papp) across MDCK-low efflux cell monolayers with the passive hepatic uptake clearance (PSpassive) measured using plated human hepatocytes
- Supplemental Data -