Journal of Pharmacology and Experimental Therapeutics: 367 (2)

November 01, 2018; Volume 367,Issue 2

Behavioral Pharmacology

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Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia
Elizabeth F. Brigham, Tom H. Johnston, Carl Brown, Jonathon D. S. Holt, Susan H. Fox, Michael P. Hill, Patrick A. Howson, Jonathan M. Brotchie and Jack T. Nguyen

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 373-381; DOI: https://doi.org/10.1124/jpet.118.247650

Cardiovascular

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Tyrosine 450 in the Voltage- and Calcium-Gated Potassium Channel of Large Conductance Channel Pore-Forming (slo1) Subunit Mediates Cholesterol Protection against Alcohol-Induced Constriction of Cerebral Arteries
Kelsey North, Shivantika Bisen, Alex M. Dopico and Anna N. Bukiya

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 234-244; DOI: https://doi.org/10.1124/jpet.118.250514

Cellular and Molecular

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Beta-3 Adrenoceptor Signaling Pathways in Urothelial and Smooth Muscle Cells in the Presence of Succinate
Abubakr Mossa, Monica Velasquez Flores, Hieu Nguyen, Philippe G. Cammisotto and Lysanne Campeau

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 252-259; DOI: https://doi.org/10.1124/jpet.118.249979
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Induced Pluripotent Stem Cell–Derived Podocyte-Like Cells as Models for Assessing Mechanisms Underlying Heritable Disease Phenotype: Initial Studies Using Two Alport Syndrome Patient Lines Indicate Impaired Potassium Channel Activity
John M. Haynes, James N. Selby, Teresa H. Vandekolk, Isaiah P. L. Abad, Joan K. Ho, Wai-Ling Lieuw, Katie Leach, Judith Savige, Sheetal Saini, Craig L. Fisher and Sharon D. Ricardo

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 335-347; DOI: https://doi.org/10.1124/jpet.118.250142

Chemotherapy, Antibiotics, and Gene Therapy

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Parapheromones Suppress Chemotherapy Side Effects
Goeun Lee, Eunhee Yang, Sojin Kim, Cheung-Seog Park, Yong Seek Park and Young-Ho Jin

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 215-221; DOI: https://doi.org/10.1124/jpet.118.251363

Drug Discovery and Translational Medicine

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A Pharmacokinetic/Pharmacodynamic Model to Predict Effective HIV Prophylaxis Dosing Strategies for People Who Inject Drugs
Katy L. Garrett, Jingxian Chen, Brian M. Maas, Mackenzie L. Cottrell, Heather A. Prince, Craig Sykes, Amanda P. Schauer, Nicole White and Julie B. Dumond

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 245-251; DOI: https://doi.org/10.1124/jpet.118.251009
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In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder
Jean M. Bidlack, Brian I. Knapp, Daniel R. Deaver, Margarita Plotnikava, Derrick Arnelle, Angela M. Wonsey, May Fern Toh, Sokhom S. Pin and Mark N. Namchuk

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 267-281; DOI: https://doi.org/10.1124/jpet.118.249839

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Impairment of Nitric Oxide Pathway by Intravascular Hemolysis Plays a Major Role in Mice Esophageal Hypercontractility: Reversion by Soluble Guanylyl Cyclase Stimulator
Fabio Henrique Silva, Kleber Yotsumoto Fertrin, Eduardo Costa Alexandre, Fabiano Beraldi Calmasini, Carla Fernanda Franco-Penteado and Fernando Ferreira Costa

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 194-202; DOI: https://doi.org/10.1124/jpet.118.249581
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Nucleos(t)ide Analogs Do Not Independently Influence Hepatic Fibrosis and Portal Hypertension beyond Viral Suppression in CBDL-Induced Cirrhotic Rat
Yu-Hsin Hsieh, Hui-Chun Huang, Ching-Chih Chang, Chiao-Lin Chuang, Fa-Yauh Lee, Shao-Jung Hsu, Yi-Hsiang Huang, Ming-Chih Hou and Shou-Dong Lee

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 260-266; DOI: https://doi.org/10.1124/jpet.118.250431
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Inhibition of Intestinal Epithelial Wound Healing through Protease-Activated Receptor-2 Activation in Caco2 Cells
Elizabeth H. Fernando, Marilyn H. Gordon, Paul L. Beck and Wallace K. MacNaughton

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 382-392; DOI: https://doi.org/10.1124/jpet.118.249524

Inflammation, Immunopharmacology, and Asthma

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The Antinociceptive and Anti-Inflammatory Properties of the α7 nAChR Weak Partial Agonist p-CF₃ N,N-diethyl-N′-phenylpiperazine
Marta Quadri, Deniz Bagdas, Wisam Toma, Clare Stokes, Nicole A. Horenstein, M. Imad Damaj and Roger. L. Papke

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 203-214; DOI: https://doi.org/10.1124/jpet.118.249904

Metabolism, Transport, and Pharmacogenomics

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Organic Anion Transporter 2–Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability–Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs
Emi Kimoto, Sumathy Mathialagan, Laurie Tylaska, Mark Niosi, Jian Lin, Anthony A. Carlo, David A. Tess and Manthena V. S. Varma

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 322-334; DOI: https://doi.org/10.1124/jpet.118.252049

Neuropharmacology

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Interactions between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142
Megan J. Moerke, Subramaniam Ananthan, Matthew L. Banks, Jose M. Eltit, Kelen C. Freitas, Amy R. Johnson, Surendra K. Saini, Tyler W. E. Steele and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 222-233; DOI: https://doi.org/10.1124/jpet.118.250902
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A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo
Luisa L. Scott, Sangeetha Iyer, Ashley E. Philpo, Melva N. Avalos, Natalie S. Wu, Ted Shi, Brooke A. Prakash, Thanh-Tu Nguyen, S. John Mihic, Richard W. Aldrich and Jonathan T. Pierce

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 282-290; DOI: https://doi.org/10.1124/jpet.118.251918
Open Access
Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction
Yong-Xin Li, Jia-Ying Yang, Miguel Alcantara, Grigor Abelian, Ashutosh Kulkarni, Ursula Staubli and Alan C. Foster

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 292-301; DOI: https://doi.org/10.1124/jpet.118.251116
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Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents
Xin Wu, Ramkumar Kuruba and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 302-321; DOI: https://doi.org/10.1124/jpet.117.247106
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Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C–Derived Protein NS5A Targeting Kv2.1 Potassium Channels
Jason A. Justice, Daniel T. Manjooran, Chung-Yang Yeh, Karen A. Hartnett-Scott, Anthony J. Schulien, Gabrielle J. Kosobucki, Shalom Mammen, Michael J. Palladino and Elias Aizenman

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 348-355; DOI: https://doi.org/10.1124/jpet.118.252338
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Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure
Rakesh K. Sit, Zrinka Kovarik, Nikolina Maček Hrvat, Suzana Žunec, Carol Green, Valery V. Fokin, K. Barry Sharpless, Zoran Radić and Palmer Taylor

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 363-372; DOI: https://doi.org/10.1124/jpet.118.249383

Toxicology

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5-HT_2A Receptor Agonist-Induced Hyperthermia Is Induced via Vasoconstriction by Peripheral 5-HT_2A Receptors and Brown Adipose Tissue Thermogenesis by Peripheral Serotonin Loss at a High Ambient Temperature
Mami Nakamura, Kaori Shintani-Ishida and Hiroshi Ikegaya

Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 356-362; DOI: https://doi.org/10.1124/jpet.118.250217

Erratum

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Correction to “Antagonism of Aryl Hydrocarbon Receptor Signaling by 6, 2′,4′-Trimethoxyflavone”
Journal of Pharmacology and Experimental Therapeutics November 2018, 367 (2) 291; DOI: https://doi.org/10.1124/jpet.109.158261err

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Table of Contents

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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