Research ArticleDrug Discovery and Translational Medicine
Role of Interstitial Fluid Turnover on Target Suppression by Therapeutic Biologics Using a Minimal Physiologically Based Pharmacokinetic Model
Xiaobing Li, William J. Jusko and Yanguang Cao
Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 1-8; DOI: https://doi.org/10.1124/jpet.118.250134
Xiaobing Li
Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China (X.L.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (X.L., Y.C.); and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical, Sciences, State University of New York at Buffalo, Buffalo, New York (W.J.J.)
William J. Jusko
Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China (X.L.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (X.L., Y.C.); and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical, Sciences, State University of New York at Buffalo, Buffalo, New York (W.J.J.)
Yanguang Cao
Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China (X.L.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (X.L., Y.C.); and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical, Sciences, State University of New York at Buffalo, Buffalo, New York (W.J.J.)

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Research ArticleDrug Discovery and Translational Medicine
ISF Turnover Affects Target Suppression of Biologics
Xiaobing Li, William J. Jusko and Yanguang Cao
Journal of Pharmacology and Experimental Therapeutics October 1, 2018, 367 (1) 1-8; DOI: https://doi.org/10.1124/jpet.118.250134
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