Journal of Pharmacology and Experimental Therapeutics: 367 (1)

October 01, 2018; Volume 367,Issue 1

Minireviews

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Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity
Daniel P. Heruth, Katherine Shortt, Nini Zhang, Ding-You Li, Li Q. Zhang and Shui Qing Ye

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 95-100; DOI: https://doi.org/10.1124/jpet.118.248583
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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?
Erifili Hatziagelaki, Maria Adamaki, Irene Tsilioni, George Dimitriadis and Theoharis C. Theoharides

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 155-167; DOI: https://doi.org/10.1124/jpet.118.250845

Cardiovascular

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Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization
Sheik Pran Babu Sardar Pasha, Kamakshi Sishtla, Rania S. Sulaiman, Bomina Park, Trupti Shetty, Fenil Shah, Melissa L. Fishel, James H. Wikel, Mark R. Kelley and Timothy W. Corson

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 108-118; DOI: https://doi.org/10.1124/jpet.118.248088

Cellular and Molecular

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Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H₄ Receptor–Mediated Chemotaxis of Mast Cells
Atsuo Kuramasu, Mie Wakabayashi, Makoto Inui and Kazuhiko Yanai

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 9-19; DOI: https://doi.org/10.1124/jpet.118.249706
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The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability
Carrie Bowman Dalley, Barbara Wroblewska, Barry B. Wolfe and Jarda T. Wroblewski

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 59-70; DOI: https://doi.org/10.1124/jpet.118.250159
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Binding Characteristics of Two Oxytocin Variants and Vasopressin at Oxytocin Receptors from Four Primate Species with Different Social Behavior Patterns
Jack H. Taylor, Nancy A. Schulte, Jeffrey A. French and Myron L. Toews

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 101-107; DOI: https://doi.org/10.1124/jpet.118.250852
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Inhibition of Multidrug Resistance Proteins by MK 571 Enhances Bladder, Prostate, and Urethra Relaxation through cAMP or cGMP Accumulation
Gabriela Maria Bertollotto, Mariana Gonçalves de Oliveira, Eduardo Costa Alexandre, Fabiano Beraldi Calmasini, Gabriela Reolon Passos, Edson Antunes and Fabiola Zakia Mónica

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 138-146; DOI: https://doi.org/10.1124/jpet.118.250076

Drug Discovery and Translational Medicine

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Role of Interstitial Fluid Turnover on Target Suppression by Therapeutic Biologics Using a Minimal Physiologically Based Pharmacokinetic Model
Xiaobing Li, William J. Jusko and Yanguang Cao

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 1-8; DOI: https://doi.org/10.1124/jpet.118.250134
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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor
Martin L. Marro, Andrew W. Patterson, Lac Lee, Lin Deng, Aimee Reynolds, Xianglin Ren, Laura Axford, Anup Patnaik, Micah Hollis-Symynkywicz, Nigel Casson, Dominique Custeau, Lisa Ames, Sally Loi, Lihe Zhang, Toshiyuki Honda, Jutta Blank, Tyler J. Harrison, Julien P. N. Papillon, Lawrence G. Hamann, Jovita Marcinkeviciene and Jean B. Regard

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 147-154; DOI: https://doi.org/10.1124/jpet.118.248435

Gastrointestinal, Hepatic, Pulmonary, and Renal

Open Access
PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway
Brigitte Grouix, Francois Sarra-Bournet, Martin Leduc, Jean-Christophe Simard, Kathy Hince, Lilianne Geerts, Alexandra Blais, Liette Gervais, Alexandre Laverdure, Alexandra Felton, Jonathan Richard, Jugurtha Ouboudinar, William Gagnon, François A. Leblond, Pierre Laurin and Lyne Gagnon

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 71-81; DOI: https://doi.org/10.1124/jpet.118.250068
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Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist
Steven E. Trasino, Xiao-Han Tang, Maria M. Shevchuk, Mary E. Choi and Lorraine J. Gudas

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 82-94; DOI: https://doi.org/10.1124/jpet.118.249375
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Phosphate Binder, Ferric Citrate, Attenuates Anemia, Renal Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in 5/6 Nephrectomized CKD Rats
Wanghui Jing, Ane C. F. Nunes, Ted Farzaneh, Mahyar Khazaeli, Wei Ling Lau and Nosratola D. Vaziri

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 129-137; DOI: https://doi.org/10.1124/jpet.118.249961

Inflammation, Immunopharmacology, and Asthma

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Interferon-α–Mediated Activation of T Cells from Healthy and HIV-Infected Individuals Is Suppressed by Δ⁹-Tetrahydrocannabinol
Joseph E. Henriquez, Michael D. Rizzo, Robert B. Crawford, Peter Gulick and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 49-58; DOI: https://doi.org/10.1124/jpet.118.250308

Metabolism, Transport, and Pharmacogenomics

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Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy
Rui Ju, Kailun Fei, Siang Li, Chen Chen, Lei Zhu, Juan Li, Dechang Zhang, Lei Guo and Caiying Ye

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 20-27; DOI: https://doi.org/10.1124/jpet.118.249326
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MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema
Herana Kamal Seneviratne, Craig W. Hendrix, Edward J. Fuchs and Namandjé N. Bumpus

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 40-48; DOI: https://doi.org/10.1124/jpet.118.250357
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Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver
Vivaswath S. Ayyar, Siddharth Sukumaran, Debra C. DuBois, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 168-183; DOI: https://doi.org/10.1124/jpet.118.251959

Neuropharmacology

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Dual Antidepressant Duloxetine Blocks Nicotinic Receptor Currents, Calcium Signals and Exocytosis in Chromaffin Cells Stimulated with Acetylcholine
Carmen Nanclares, Isabel Gameiro-Ros, Iago Méndez-López, Carmen Martínez-Ramírez, J. Fernando Padín-Nogueira, Inés Colmena, Andrés M. Baraibar, Luis Gandía and Antonio G. García

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 28-39; DOI: https://doi.org/10.1124/jpet.118.250969
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Tamoxifen Directly Interacts with the Dopamine Transporter
Sarah R. Mikelman, Bipasha Guptaroy, Kyle C. Schmitt, Kymry T. Jones, Juan Zhen, Maarten E. A. Reith and Margaret E. Gnegy

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 119-128; DOI: https://doi.org/10.1124/jpet.118.248179

Toxicology

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Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca²⁺
Andrea Guidarelli, Mara Fiorani and Orazio Cantoni

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 184-193; DOI: https://doi.org/10.1124/jpet.118.250480

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Table of Contents

Minireviews

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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