Journal of Pharmacology and Experimental Therapeutics: 366 (2)

August 01, 2018; Volume 366,Issue 2

Minireviews

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Molecular Basis of the Brain Renin Angiotensin System in Cardiovascular and Neurologic Disorders: Uncovering a Key Role for the Astroglial Angiotensin Type 1 Receptor AT1R
Dhanush Haspula and Michelle A. Clark

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 251-264; DOI: https://doi.org/10.1124/jpet.118.248831
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The Influence of Nicotine on Lung Tumor Growth, Cancer Chemotherapy, and Chemotherapy-Induced Peripheral Neuropathy
S. Lauren Kyte and David A. Gewirtz

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 303-313; DOI: https://doi.org/10.1124/jpet.118.249359

Behavioral Pharmacology

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Involvement of Nicotinic Receptor Subtypes in the Behavioral Effects of Nicotinic Drugs in Squirrel Monkeys
Sarah L. Withey, Michelle R. Doyle, Jack Bergman and Rajeev I. Desai

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 397-409; DOI: https://doi.org/10.1124/jpet.118.248070

Cardiovascular

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Activation of Large Conductance, Calcium-Activated Potassium Channels by Nitric Oxide Mediates Apelin-Induced Relaxation of Isolated Rat Coronary Arteries
Amreen Mughal, Chengwen Sun and Stephen T. O’Rourke

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 265-273; DOI: https://doi.org/10.1124/jpet.118.248682
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A Retinoic Acid β₂-Receptor Agonist Exerts Cardioprotective Effects
Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J. Gudas and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 314-321; DOI: https://doi.org/10.1124/jpet.118.250605

Chemotherapy, Antibiotics, and Gene Therapy

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Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5′-Phosphate and Folinic Acid in Tandem
David Machover, Emma Goldschmidt, Rosella Mollicone, Farhad Haghighi-Rad, Christophe Desterke, Yann Gaston-Mathé, Raphaël Saffroy, Claude Boucheix and Julien Dairou

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 238-243; DOI: https://doi.org/10.1124/jpet.118.249367
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Ibuprofen Decreases Spontaneous Activity and Enhances Nerve-Evoked Contractions to Minimize Mitomycin C-Induced Bladder Dysfunction
Eliza G. West, Ryan Lang, Donna Sellers, Russ Chess-Williams and Catherine McDermott

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 282-290; DOI: https://doi.org/10.1124/jpet.118.248989

Drug Discovery and Translational Medicine

Open Access
Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered α_vβ₃ Integrin Antagonist, for the Treatment of Retinal Diseases
Ben C. Askew, Takeru Furuya and D. Scott Edwards

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 244-250; DOI: https://doi.org/10.1124/jpet.118.248427
Open Access
Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application
Chuan Shen, Andrea Iskenderian, Dianna Lundberg, Tao He, Kathleen Palmieri, Robert Crooker, Qingwei Deng, Matthew Traylor, Sheng Gu, Haojing Rong, David Ehmann, Brian Pescatore, Bettina Strack-Logue, Alla Romashko, George Baviello, John Gill, Bohong Zhang, Muthuraman Meiyappan, Clark Pan and Angela W. Norton

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 291-302; DOI: https://doi.org/10.1124/jpet.118.248195
Open Access
TAS-303, a Novel Selective Norepinephrine Reuptake Inhibitor that Increases Urethral Pressure in Rats, Indicating Its Potential as a Therapeutic Agent for Stress Urinary Incontinence
Hiroya Mizutani, Fukumitsu Sakakibara, Masahito Komuro and Eiji Sasaki

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 322-331; DOI: https://doi.org/10.1124/jpet.118.248039
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OBE022, an Oral and Selective Prostaglandin F₂_α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor
Oliver Pohl, André Chollet, Sung Hye Kim, Lucia Riaposova, François Spézia, Frédéric Gervais, Philippe Guillaume, Philippe Lluel, Murielle Méen, Frédérique Lemaux, Vasso Terzidou, Phillip R. Bennett and Jean-Pierre Gotteland

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 349-364; DOI: https://doi.org/10.1124/jpet.118.247668
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Novel Polyphenols That Inhibit Colon Cancer Cell Growth Affecting Cancer Cell Metabolism
Marta Gómez de Cedrón, Teodoro Vargas, Andrés Madrona, Aranza Jiménez, María-Jesús Pérez-Pérez, José-Carlos Quintela, Guillermo Reglero, Ana San-Félix and Ana Ramírez de Molina

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 377-389; DOI: https://doi.org/10.1124/jpet.118.248278
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Effect of ASP6432, a Novel Type 1 Lysophosphatidic Acid Receptor Antagonist, on Urethral Function and Prostate Cell Proliferation
Kazuyuki Sakamoto, Yukiko Noguchi, Koji Ueshima, Hisashi Yamakuni, Akiyoshi Ohtake, Shuichi Sato, Kenichiro Ishizu, Naomi Hosogai, Eiji Kawaminami, Masahiro Takeda and Noriyuki Masuda

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 390-396; DOI: https://doi.org/10.1124/jpet.118.247908

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization
Ehsan N. Mohammadi, Casey O. Ligon, Ada Silos-Santiago, Pei Ge, Caroline Kurtz, Carolyn Higgins, Gerhard Hannig and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 274-281; DOI: https://doi.org/10.1124/jpet.118.248567
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Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms
Wanghui Jing, Yasaman Safarpour, Ting Zhang, Pengqi Guo, Guoning Chen, Xiaoming Wu, Qiang Fu and Yitao Wang

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 332-340; DOI: https://doi.org/10.1124/jpet.118.249615

Inflammation, Immunopharmacology, and Asthma

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Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1β Level
Chao Zhang, Wenfeng Zeng, Yi Yao, Bin Xu, Xiuli Wei, Luoyang Wang, Xiaozhe Yin, Apurba Kumar Barman, Fayun Zhang, Chunling Zhang, Qibin Song and Wei Liang

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 341-348; DOI: https://doi.org/10.1124/jpet.118.248807

Neuropharmacology

Open Access
Characterization of the Neurochemical and Behavioral Effects of Solriamfetol (JZP-110), a Selective Dopamine and Norepinephrine Reuptake Inhibitor
Michelle G. Baladi, Michael J. Forster, Michael B. Gatch, Richard B. Mailman, Danielle L. Hyman, Lawrence P. Carter and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 367-376; DOI: https://doi.org/10.1124/jpet.118.248120

Erratum

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Correction to “Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming that Enhances Nanocarrier Deposition and Efficacy”
Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 365-366; DOI: https://doi.org/10.1124/jpet.117.199109err

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Neuropharmacology

Erratum

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