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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2018; Volume 366,Issue 2

Minireviews

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    Molecular Basis of the Brain Renin Angiotensin System in Cardiovascular and Neurologic Disorders: Uncovering a Key Role for the Astroglial Angiotensin Type 1 Receptor AT1R
    Dhanush Haspula and Michelle A. Clark
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 251-264; DOI: https://doi.org/10.1124/jpet.118.248831
  • You have access
    The Influence of Nicotine on Lung Tumor Growth, Cancer Chemotherapy, and Chemotherapy-Induced Peripheral Neuropathy
    S. Lauren Kyte and David A. Gewirtz
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 303-313; DOI: https://doi.org/10.1124/jpet.118.249359

Behavioral Pharmacology

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    Involvement of Nicotinic Receptor Subtypes in the Behavioral Effects of Nicotinic Drugs in Squirrel Monkeys
    Sarah L. Withey, Michelle R. Doyle, Jack Bergman and Rajeev I. Desai
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 397-409; DOI: https://doi.org/10.1124/jpet.118.248070

Cardiovascular

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    Activation of Large Conductance, Calcium-Activated Potassium Channels by Nitric Oxide Mediates Apelin-Induced Relaxation of Isolated Rat Coronary Arteries
    Amreen Mughal, Chengwen Sun and Stephen T. O’Rourke
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 265-273; DOI: https://doi.org/10.1124/jpet.118.248682
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    A Retinoic Acid β2-Receptor Agonist Exerts Cardioprotective Effects
    Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J. Gudas and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 314-321; DOI: https://doi.org/10.1124/jpet.118.250605

Chemotherapy, Antibiotics, and Gene Therapy

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    Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5′-Phosphate and Folinic Acid in Tandem
    David Machover, Emma Goldschmidt, Rosella Mollicone, Farhad Haghighi-Rad, Christophe Desterke, Yann Gaston-Mathé, Raphaël Saffroy, Claude Boucheix and Julien Dairou
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 238-243; DOI: https://doi.org/10.1124/jpet.118.249367
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    Ibuprofen Decreases Spontaneous Activity and Enhances Nerve-Evoked Contractions to Minimize Mitomycin C-Induced Bladder Dysfunction
    Eliza G. West, Ryan Lang, Donna Sellers, Russ Chess-Williams and Catherine McDermott
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 282-290; DOI: https://doi.org/10.1124/jpet.118.248989

Drug Discovery and Translational Medicine

  • Open Access
    Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered αvβ3 Integrin Antagonist, for the Treatment of Retinal Diseases
    Ben C. Askew, Takeru Furuya and D. Scott Edwards
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 244-250; DOI: https://doi.org/10.1124/jpet.118.248427
  • Open Access
    Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application
    Chuan Shen, Andrea Iskenderian, Dianna Lundberg, Tao He, Kathleen Palmieri, Robert Crooker, Qingwei Deng, Matthew Traylor, Sheng Gu, Haojing Rong, David Ehmann, Brian Pescatore, Bettina Strack-Logue, Alla Romashko, George Baviello, John Gill, Bohong Zhang, Muthuraman Meiyappan, Clark Pan and Angela W. Norton
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 291-302; DOI: https://doi.org/10.1124/jpet.118.248195
  • Open Access
    TAS-303, a Novel Selective Norepinephrine Reuptake Inhibitor that Increases Urethral Pressure in Rats, Indicating Its Potential as a Therapeutic Agent for Stress Urinary Incontinence
    Hiroya Mizutani, Fukumitsu Sakakibara, Masahito Komuro and Eiji Sasaki
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 322-331; DOI: https://doi.org/10.1124/jpet.118.248039
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    OBE022, an Oral and Selective Prostaglandin F2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor
    Oliver Pohl, André Chollet, Sung Hye Kim, Lucia Riaposova, François Spézia, Frédéric Gervais, Philippe Guillaume, Philippe Lluel, Murielle Méen, Frédérique Lemaux, Vasso Terzidou, Phillip R. Bennett and Jean-Pierre Gotteland
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 349-364; DOI: https://doi.org/10.1124/jpet.118.247668
  • Novel Polyphenols That Inhibit Colon Cancer Cell Growth Affecting Cancer Cell Metabolism
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    Novel Polyphenols That Inhibit Colon Cancer Cell Growth Affecting Cancer Cell Metabolism
    Marta Gómez de Cedrón, Teodoro Vargas, Andrés Madrona, Aranza Jiménez, María-Jesús Pérez-Pérez, José-Carlos Quintela, Guillermo Reglero, Ana San-Félix and Ana Ramírez de Molina
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 377-389; DOI: https://doi.org/10.1124/jpet.118.248278
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    Effect of ASP6432, a Novel Type 1 Lysophosphatidic Acid Receptor Antagonist, on Urethral Function and Prostate Cell Proliferation
    Kazuyuki Sakamoto, Yukiko Noguchi, Koji Ueshima, Hisashi Yamakuni, Akiyoshi Ohtake, Shuichi Sato, Kenichiro Ishizu, Naomi Hosogai, Eiji Kawaminami, Masahiro Takeda and Noriyuki Masuda
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 390-396; DOI: https://doi.org/10.1124/jpet.118.247908

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization
    Ehsan N. Mohammadi, Casey O. Ligon, Ada Silos-Santiago, Pei Ge, Caroline Kurtz, Carolyn Higgins, Gerhard Hannig and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 274-281; DOI: https://doi.org/10.1124/jpet.118.248567
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    Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms
    Wanghui Jing, Yasaman Safarpour, Ting Zhang, Pengqi Guo, Guoning Chen, Xiaoming Wu, Qiang Fu and Yitao Wang
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 332-340; DOI: https://doi.org/10.1124/jpet.118.249615

Inflammation, Immunopharmacology, and Asthma

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    Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1β Level
    Chao Zhang, Wenfeng Zeng, Yi Yao, Bin Xu, Xiuli Wei, Luoyang Wang, Xiaozhe Yin, Apurba Kumar Barman, Fayun Zhang, Chunling Zhang, Qibin Song and Wei Liang
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 341-348; DOI: https://doi.org/10.1124/jpet.118.248807

Neuropharmacology

  • Open Access
    Characterization of the Neurochemical and Behavioral Effects of Solriamfetol (JZP-110), a Selective Dopamine and Norepinephrine Reuptake Inhibitor
    Michelle G. Baladi, Michael J. Forster, Michael B. Gatch, Richard B. Mailman, Danielle L. Hyman, Lawrence P. Carter and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 367-376; DOI: https://doi.org/10.1124/jpet.118.248120

Erratum

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    Correction to “Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming that Enhances Nanocarrier Deposition and Efficacy”
    Journal of Pharmacology and Experimental Therapeutics August 2018, 366 (2) 365-366; DOI: https://doi.org/10.1124/jpet.117.199109err
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Journal of Pharmacology and Experimental Therapeutics: 366 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 366, Issue 2
1 Aug 2018
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
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Jump to

  • Minireviews
  • Behavioral Pharmacology
  • Cardiovascular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Neuropharmacology
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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