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Research ArticleDrug Discovery and Translational Medicine

Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats

James D. Boghosian, Anita Luethy and Joseph F. Cotten
Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 105-112; DOI: https://doi.org/10.1124/jpet.118.248377

Article Information

vol. 366 no. 1 105-112
DOI 
https://doi.org/10.1124/jpet.118.248377
PubMed 
29674333
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 8, 2018
  • Accepted April 18, 2018
  • Published online June 4, 2018.

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Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. James D. Boghosian,
  2. Anita Luethy, and
  3. Joseph F. Cotten
  1. Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (J.D.B., A.L., J.F.C.); and Department of Anesthesia, Kantonsspital Aarau, Aarau, Switzerland (A.L.)
  1. Address correspondence to:
    Dr. Joseph F. Cotten, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, GRB 444, Boston, MA 02114. E-mail: jcotten{at}mgh.harvard.edu
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Research ArticleDrug Discovery and Translational Medicine

TRH Reversal of Opioid-Induced Respiratory Depression

James D. Boghosian, Anita Luethy and Joseph F. Cotten
Journal of Pharmacology and Experimental Therapeutics July 1, 2018, 366 (1) 105-112; DOI: https://doi.org/10.1124/jpet.118.248377
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