Journal of Pharmacology and Experimental Therapeutics: 366 (1)

July 01, 2018; Volume 366,Issue 1

Minireviews

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Involvement of Activated Brain Stress Responsive Systems in Excessive and “Relapse” Alcohol Drinking in Rodent Models: Implications for Therapeutics
Yan Zhou and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 9-20; DOI: https://doi.org/10.1124/jpet.117.245621

Behavioral Pharmacology

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Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABA_A Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys
Angela N. Duke, Zhiqiang Meng, Donna M. Platt, John R. Atack, Gerard R. Dawson, David S. Reynolds, V. V. N. Phani Babu Tiruveedhula, Guanguan Li, Michael Rajesh Stephen, Werner Sieghart, James M. Cook and James K. Rowlett

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 145-157; DOI: https://doi.org/10.1124/jpet.118.249250
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Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy
Zachary A. Curry, Jenny L. Wilkerson, Deniz Bagdas, S. Lauren Kyte, Nipa Patel, Giulia Donvito, Mohammed A. Mustafa, Justin L. Poklis, Micah J. Niphakis, Ku-Lung Hsu, Benjamin F. Cravatt, David A. Gewirtz, M. Imad Damaj and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 169-183; DOI: https://doi.org/10.1124/jpet.117.245704

Cardiovascular

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Cerivastatin Nanoliposome as a Potential Disease Modifying Approach for the Treatment of Pulmonary Arterial Hypertension
Young Lee, S. Balakrishna Pai, Ravi V. Bellamkonda, David H. Thompson and Jaipal Singh

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 66-74; DOI: https://doi.org/10.1124/jpet.118.247643
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Pharmacology of Cardio-Oncology: Chronotropic and Lusitropic Effects of B-Type Natriuretic Peptide in Cancer Patients with Early Diastolic Dysfunction Induced by Anthracycline or Nonanthracycline Chemotherapy
Pierantonio Menna, Vito Calabrese, Grazia Armento, Ombretta Annibali, Carlo Greco, Emanuela Salvatorelli, Francesco Marchesi, Giorgio Reggiardo and Giorgio Minotti

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 158-168; DOI: https://doi.org/10.1124/jpet.118.249235

Cellular and Molecular

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Contraction of Rat Cauda Epididymis Smooth Muscle to α₁-Adrenoceptor Activation Is Mediated by α_1A-Adrenoceptors
Enio S. A. Pacini, Anthony C. S. Castilho, Flavia Hebeler-Barbosa, André S. Pupo and Luiz R. A. Kiguti

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 21-28; DOI: https://doi.org/10.1124/jpet.117.246710

Chemotherapy, Antibiotics, and Gene Therapy

Open Access
FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells
Shinji Mima, Chihaya Kakinuma, Tamami Higuchi, Kazunori Saeki, Takayuki Yamada, Rena Uematsu, Miki Ishino, Nobuko Kito, Hiroki Nishikawa, Hidenobu Kuniyoshi, Takuya Matsumoto, Hideyasu Fujiwara, Linda J. Paradiso, Yasuhiro Shimada and Hiroyuki Iwamura

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 125-135; DOI: https://doi.org/10.1124/jpet.118.248740

Drug Discovery and Translational Medicine

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Soy Phosphatidylglycerol Reduces Inflammation in a Contact Irritant Ear Edema Mouse Model In Vivo
Ding Xie, Vivek Choudhary, Mutsa Seremwe, John G. Edwards, Angela Wang, Aaron C. Emmons, Katherine A. Bollag, Maribeth H. Johnson and Wendy B. Bollag

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 1-8; DOI: https://doi.org/10.1124/jpet.117.244756
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ONO-8590580, a Novel GABA_A α5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models
Soichi Kawaharada, Miki Nakanishi, Nobuto Nakanishi, Keisuke Hazama, Masato Higashino, Tetsuya Yasuhiro, Arwel Lewis, Gary S. Clark, Mark S. Chambers, Scott A. Maidment, Seishi Katsumata and Shuji Kaneko

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 58-65; DOI: https://doi.org/10.1124/jpet.117.247627
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TAS05567, a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor, Abrogates Immunoglobulin-Mediated Autoimmune and Allergic Reactions in Rodent Models
Hiroaki Hayashi, Ryusuke Kaneko, Shunsuke Demizu, Daichi Akasaka, Manabu Tayama, Takafumi Harada, Hiroki Irie, Yoshio Ogino, Naoko Fujino and Eiji Sasaki

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 84-95; DOI: https://doi.org/10.1124/jpet.118.248153
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Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts
Zinnia P. Parra-Guillen, Victor Mangas-Sanjuan, Maria Garcia-Cremades, Iñaki F. Troconiz, Gary Mo, Celine Pitou, Philip W. Iversen and Johan E. Wallin

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 96-104; DOI: https://doi.org/10.1124/jpet.118.248286
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Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats
James D. Boghosian, Anita Luethy and Joseph F. Cotten

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 105-112; DOI: https://doi.org/10.1124/jpet.118.248377
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Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-κB Activation
Wei Wang, Bo Zhang, Arul M. Mani, Zhongzhi Wu, Yu Fan, Wei Li and Zhao-Hui Wu

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 184-193; DOI: https://doi.org/10.1124/jpet.118.249151
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Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia
Yoichi Kawashima, Yoshihiro Eguchi, Tohru Yamazaki, Minako Karahashi, Hiroshi Kawai and Naomi Kudo

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 194-204; DOI: https://doi.org/10.1124/jpet.117.246165

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Luminal Polyethylene Glycol Alleviates Intestinal Preservation Injury Irrespective of Molecular Size
Anna Casselbrant, John M. Söfteland, Mats Hellström, Mantas Malinauskas and Mihai Oltean

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 29-36; DOI: https://doi.org/10.1124/jpet.117.247023
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The Extracellular cAMP-Adenosine Pathway in Airway Smooth Muscle
Enio S. A. Pacini, Sarah Sanders-Silveira and Rosely O. Godinho

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 75-83; DOI: https://doi.org/10.1124/jpet.118.247734
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[Lys⁵,MeLeu⁹,Nle¹⁰]-NKA_(4–10) Elicits NK2 Receptor–Mediated Micturition and Defecation, and NK1 Receptor–Mediated Emesis and Hypotension, in Conscious Dogs
Nadia M. J. Rupniak, Mary Katofiasc, Alexander Walz, Karl B. Thor and Edward C. Burgard

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 136-144; DOI: https://doi.org/10.1124/jpet.118.248765

Inflammation, Immunopharmacology, and Asthma

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Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β₂-Adrenoceptor Agonists
Dong Yan, Omar Hamed, Taruna Joshi, Mahmoud M. Mostafa, Kyla C. Jamieson, Radhika Joshi, Robert Newton and Mark A. Giembycz

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 220-236; DOI: https://doi.org/10.1124/jpet.118.249292

Metabolism, Transport, and Pharmacogenomics

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Hepatobiliary Disposition of Atovaquone: A Case of Mechanistically Unusual Biliary Clearance
Mitesh Patel, Marta Johnson, Caroline J. Sychterz, Gareth J. Lewis, Cory Watson, Harma Ellens, Joseph W. Polli and Maciej J. Zamek-Gliszczynski

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 37-45; DOI: https://doi.org/10.1124/jpet.117.247254
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“Catch-and-Release” Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer
Frank A. Engler, Joseph Ryan Polli, Tommy Li, Bo An, Michael Otteneder, Jun Qu and Joseph P. Balthasar

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 205-219; DOI: https://doi.org/10.1124/jpet.117.246900

Toxicology

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NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis
James Watt, Alexander W. Alund, Casey F. Pulliam, Kelly E. Mercer, Larry J. Suva, Jin-Ran Chen and Martin J. J. Ronis

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 46-57; DOI: https://doi.org/10.1124/jpet.117.247262
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3,4-Dihydroxyphenylacetaldehyde-Induced Protein Modifications and Their Mitigation by N-Acetylcysteine
Yunden Jinsmaa, Yehonatan Sharabi, Patti Sullivan, Risa Isonaka and David S. Goldstein

Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 113-124; DOI: https://doi.org/10.1124/jpet.118.248492

Erratum

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Correction to “Drug Distribution into Peripheral Nerve”
Journal of Pharmacology and Experimental Therapeutics July 2018, 366 (1) 237; DOI: https://doi.org/10.1124/jpet.117.245613err

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Toxicology

Erratum

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