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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2018; Volume 365,Issue 3

Cardiovascular

  • You have access
    Inhibition of the α-Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic
    Tao Yang, David F. Meoli, Javid Moslehi and Dan M. Roden
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 460-466; DOI: https://doi.org/10.1124/jpet.117.246157
  • You have access
    Transient Receptor Potential Melastatin-8 Activation Induces Relaxation of Pulmonary Artery by Inhibition of Store-Operated Calcium Entry in Normoxic and Chronic Hypoxic Pulmonary Hypertensive Rats
    Yun-Ping Mu, Da-Cen Lin, Si-Yi Zheng, Hai-Xia Jiao, James S. K. Sham and Mo-Jun Lin
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 544-555; DOI: https://doi.org/10.1124/jpet.117.247320
  • You have access
    New Targets for Old Drugs: Cardiac Glycosides Inhibit Atrial-Specific K2P3.1 (TASK-1) Channels
    Constanze Schmidt, Felix Wiedmann, Anne-Rike Gaubatz, Antonius Ratte, Hugo A. Katus and Dierk Thomas
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 614-623; DOI: https://doi.org/10.1124/jpet.118.247692
  • Open Access
    Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
    Jenny V. Tobin, Daniel P. Zimmer, Courtney Shea, Peter Germano, Sylvie G. Bernier, Guang Liu, Kim Long, Joy Miyashiro, Sheila Ranganath, Sarah Jacobson, Kim Tang, G-Yoon Jamie Im, James Sheppeck, Joel D. Moore, Kristine Sykes, James Wakefield, Renee Sarno, Ali R. Banijamali, Albert T. Profy, G. Todd Milne, Mark G. Currie and Jaime L. Masferrer
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 664-675; DOI: https://doi.org/10.1124/jpet.117.247429

Cellular and Molecular

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    Sepiapterin Enhances Tumor Radio- and Chemosensitivities by Promoting Vascular Normalization
    Christopher S. Rabender, Ninu Bruno, Asim Alam, Gobalakrishnan Sundaresan, Jamal Zweit and Ross B. Mikkelsen
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 536-543; DOI: https://doi.org/10.1124/jpet.117.245258
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    TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence
    Ming-Fen Ho, Edroaldo Lummertz da Rocha, Cheng Zhang, James N. Ingle, Paul E. Goss, Lois E. Shepherd, Michiaki Kubo, Liewei Wang, Hu Li and Richard M. Weinshilboum
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 700-710; DOI: https://doi.org/10.1124/jpet.118.247718

Chemotherapy, Antibiotics, and Gene Therapy

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    Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation
    Keagan P. Collins, Kristen M. Jackson and Daniel L. Gustafson
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 447-459; DOI: https://doi.org/10.1124/jpet.117.245639

Drug Discovery and Translational Medicine

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    Indomethacin Enhances Brown Fat Activity
    Lei Hao, Jamie Kearns, Sheyenne Scott, Dayong Wu, Sean D. Kodani, Christophe Morisseau, Bruce D. Hammock, Xiaocun Sun, Ling Zhao and Shu Wang
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 467-475; DOI: https://doi.org/10.1124/jpet.117.246256
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    Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy
    Pui Yan Ho, Zhijian Duan, Neelu Batra, Joseph L. Jilek, Mei-Juan Tu, Jing-Xin Qiu, Zihua Hu, Theodore Wun, Primo N. Lara, Ralph W. DeVere White, Hong-Wu Chen and Ai-Ming Yu
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 494-506; DOI: https://doi.org/10.1124/jpet.118.247775
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    AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure
    Rikard Pehrson, Tove Hegelund-Myrbäck, Danen Cunoosamy, Sara Asimus, Paul Jansson, Naimish Patel, Annika Borde and Sofia Lundin
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 567-572; DOI: https://doi.org/10.1124/jpet.117.246132
  • Open Access
    Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage-Gated Calcium Channels
    Yuki Domon, Naohisa Arakawa, Tatsuya Inoue, Fumihiko Matsuda, Makoto Takahashi, Naotoshi Yamamura, Kiyonori Kai and Yutaka Kitano
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 573-582; DOI: https://doi.org/10.1124/jpet.117.247551
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    In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
    Adrian J. Mogg, Thomas Eessalu, Megan Johnson, Rebecca Wright, Helen E. Sanger, Hongling Xiao, Michael G. Crabtree, Alex Smith, Ellen M. Colvin, Douglas Schober, Donald Gehlert, Cynthia Jesudason, Paul J. Goldsmith, Michael P. Johnson, Christian C. Felder, Vanessa N. Barth and Lisa M. Broad
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 602-613; DOI: https://doi.org/10.1124/jpet.117.246454
  • Open Access
    Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery
    Keith Morrison, Franck Haag, Roland Ernst, Marc Iglarz and Martine Clozel
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 727-733; DOI: https://doi.org/10.1124/jpet.117.246058
  • You have access
    Network-Based Analysis of Bortezomib Pharmacodynamic Heterogeneity in Multiple Myeloma Cells
    Vidya Ramakrishnan and Donald E. Mager
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 734-751; DOI: https://doi.org/10.1124/jpet.118.247924

Endocrine and Diabetes

  • Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression
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    Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression
    Tae Woo Jung, Eun Jung Kyung, Hyoung-Chun Kim, Yong Kyu Shin, Sung Hoon Lee, Eon Sub Park, Ahmet Hacımüftüoğlu, A. M. Abd El-Aty and Ji Hoon Jeong
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 485-493; DOI: https://doi.org/10.1124/jpet.117.246686
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    AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis
    Natasha D. Bush, Logan K. Townsend and David C. Wright
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 526-535; DOI: https://doi.org/10.1124/jpet.118.248393

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Ultrasound Combined with Microbubbles Enhances the Effects of Methylprednisolone in Lipopolysaccharide-Induced Human Mesangial Cells
    Peng-Fei Sun, Tian Tian, Li-Na Chen, Rong-Guo Fu, Shan-Shan Xu, Hong Ai, Bing Wang, Jian Zhang, Ruo-Yan Si, Zhonglin Chai, Mark E. Cooper and Shu-Ting Ren
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 476-484; DOI: https://doi.org/10.1124/jpet.117.246223
  • Open Access
    Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents
    Fuyong Du, Simon A. Hinke, Cassandre Cavanaugh, David Polidori, Nathanial Wallace, Thomas Kirchner, Matthew Jennis, Wensheng Lang, Gee-Hong Kuo, Micheal D. Gaul, James Lenhard, Keith Demarest, Nadim J. Ajami, Yin Liang and Pamela J. Hornby
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 676-687; DOI: https://doi.org/10.1124/jpet.118.248575

Inflammation, Immunopharmacology, and Asthma

  • Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis
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    Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis
    Stefania Petrosino, Roberta Verde, Massimo Vaia, Marco Allarà, Teresa Iuvone and Vincenzo Di Marzo
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 652-663; DOI: https://doi.org/10.1124/jpet.117.244368

Metabolism, Transport, and Pharmacogenomics

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    In Vitro Assessment of Pharmacokinetic Drug-Drug Interactions of Direct Oral Anticoagulants: Type 5-Phosphodiesterase Inhibitors Are Inhibitors of Rivaroxaban and Apixaban Efflux by P-Glycoprotein
    Victor Margelidon-Cozzolino, Sophie Hodin, Elodie Jacqueroux, Olivier Delézay, Laurent Bertoletti and Xavier Delavenne
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 519-525; DOI: https://doi.org/10.1124/jpet.117.245993
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    In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey
    Ayşe Ufuk, Rachel E. Kosa, Hongying Gao, Yi-An Bi, Sweta Modi, Dana Gates, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, J. Brian Houston and Aleksandra Galetin
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 688-699; DOI: https://doi.org/10.1124/jpet.118.247767

Neuropharmacology

  • Extending a Systems Model of the APP Pathway: Separation of <em>β</em>- and <em>γ</em>-Secretase Sequential Cleavage Steps of APP
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    Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP
    Eline M. T. van Maanen, Tamara J. van Steeg, Maurice J. Ahsman, Maria S. Michener, Mary J. Savage, Matthew E. Kennedy, Huub Jan Kleijn, Julie Stone and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 507-518; DOI: https://doi.org/10.1124/jpet.117.244699
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    Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622
    Jason M. Uslaner, Scott D. Kuduk, Marion Wittmann, Henry S. Lange, Steve V. Fox, Chris Min, Natasa Pajkovic, Dawn Harris, Caroline Cilissen, Chantal Mahon, Kate Mostoller, Steve Warrington and Douglas C. Beshore
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 556-566; DOI: https://doi.org/10.1124/jpet.117.245894
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    3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield
    Shu-Hui Chuang and Doodipala Samba Reddy
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 583-601; DOI: https://doi.org/10.1124/jpet.117.246660
  • You have access
    Pharmacological Characterization of H05, a Novel Serotonin and Noradrenaline Reuptake Inhibitor with Moderate 5-HT2A Antagonist Activity for the Treatment of Depression
    Xiangqing Xu, Yaqin Wei, Qiang Guo, Song Zhao, Zhiqiang Liu, Ting Xiao, Yani Liu, Yinli Qiu, Yuanyuan Hou, Guisen Zhang and KeWei Wang
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 624-635; DOI: https://doi.org/10.1124/jpet.118.248351
  • Open Access
    The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism
    Sean L. Hammond, Katriana A. Popichak, Xi Li, Lindsay G. Hunt, Evan H. Richman, Pranav U. Damale, Edwin K. P. Chong, Donald S. Backos, Stephen Safe and Ronald B. Tjalkens
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 636-651; DOI: https://doi.org/10.1124/jpet.117.246389

Toxicology

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    Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells
    Dounia Le Guillou, Simon Bucher, Karima Begriche, Delphine Hoët, Anne Lombès, Gilles Labbe and Bernard Fromenty
    Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 711-726; DOI: https://doi.org/10.1124/jpet.117.246751
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Journal of Pharmacology and Experimental Therapeutics: 365 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 365, Issue 3
1 Jun 2018
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  • Cardiovascular
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  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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