Journal of Pharmacology and Experimental Therapeutics: 365 (2)

May 01, 2018; Volume 365,Issue 2

Minireviews

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Predictive Value of Parkinsonian Primates in Pharmacologic Studies: A Comparison between the Macaque, Marmoset, and Squirrel Monkey
Nicolas Veyres, Adjia Hamadjida and Philippe Huot

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 379-397; DOI: https://doi.org/10.1124/jpet.117.247171

Cardiovascular

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Whole-Body but Not Hepatic Knockdown of Chemerin by Antisense Oligonucleotide Decreases Blood Pressure in Rats
David J. Ferland, Bridget Seitz, Emma S. Darios, Janice M. Thompson, Steve T. Yeh, Adam E. Mullick and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 212-218; DOI: https://doi.org/10.1124/jpet.117.245456
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Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain–Fused Anticalin Protein
Yusuke Masuda, Shinji Yamaguchi, Chikako Suzuki, Takahide Aburatani, Yuki Nagano, Ryuki Miyauchi, Eiko Suzuki, Naotoshi Yamamura, Kentaro Nagatomo, Hidetoshi Ishihara, Kazuaki Okuno, Futoshi Nara, Gabriele Matschiner, Ryuji Hashimoto, Tohru Takahashi and Tomohiro Nishizawa

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 368-378; DOI: https://doi.org/10.1124/jpet.117.246652
Open Access
Morphine Interaction with Aspirin: a Double-Blind, Crossover Trial in Healthy Volunteers
Johann Bartko, Christian Schoergenhofer, Michael Schwameis, Patricia Wadowski, Jacek Kubica, Bernd Jilma and Eva-Luise Hobl

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 430-436; DOI: https://doi.org/10.1124/jpet.117.247213

Cellular and Molecular

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The N54-α_s Mutant Has Decreased Affinity for βγ and Suggests a Mechanism for Coupling Heterotrimeric G Protein Nucleotide Exchange with Subunit Dissociation
John H. Cleator, Christopher A. Wells, Jane Dingus, David T. Kurtz and John D. Hildebrandt

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 219-225; DOI: https://doi.org/10.1124/jpet.117.245779

Chemotherapy, Antibiotics, and Gene Therapy

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Impact of Infection Status and Cyclosporine on Voriconazole Pharmacokinetics in an Experimental Model of Cerebral Scedosporiosis
Bénédicte Lelièvre, Marie Briet, Charlotte Godon, Pierre Legras, Jérémie Riou, Patrick Vandeputte, Bertrand Diquet and Jean-Philippe Bouchara

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 408-412; DOI: https://doi.org/10.1124/jpet.117.245449

Drug Discovery and Translational Medicine

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Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis
Mark R. Tanner, Michael W. Pennington, Brayden H. Chamberlain, Redwan Huq, Elizabeth J. Gehrmann, Teresina Laragione, Pércio S. Gulko and Christine Beeton

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 227-236; DOI: https://doi.org/10.1124/jpet.117.245118
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Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M₄ Muscarinic Receptor as a Novel Therapeutic Target
Rocco G. Gogliotti, Nicole M. Fisher, Branden J. Stansley, Carrie K. Jones, Craig W. Lindsley, P. Jeffrey Conn and Colleen M. Niswender

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 291-300; DOI: https://doi.org/10.1124/jpet.117.246991
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Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population
James P. Apland, Vassiliki Aroniadou-Anderjaska, Taiza H. Figueiredo, Volodymyr I. Pidoplichko, Katia Rossetti and Maria F. M. Braga

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 314-326; DOI: https://doi.org/10.1124/jpet.117.245969
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Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats
Michael D. Raleigh, Megan Laudenbach, Federico Baruffaldi, Samantha J. Peterson, Michaela J. Roslawski, Angela K. Birnbaum, F. Ivy Carroll, Scott P. Runyon, Scott Winston, Paul R. Pentel and Marco Pravetoni

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 346-353; DOI: https://doi.org/10.1124/jpet.117.247049
Open Access
Identification and Characterization of Novel Receptor-Interacting Serine/Threonine‐Protein Kinase 2 Inhibitors Using Structural Similarity Analysis
Mohamed Salla, Rodrigo Aguayo-Ortiz, Gaddafi I. Danmaliki, Alaa Zare, Ahmed Said, Jack Moore, Vrajeshkumar Pandya, Robin Manaloor, Sunny Fong, Anna R. Blankstein, Spencer B. Gibson, Laura Ramos Garcia, Pascal Meier, Khushwant S. Bhullar, Basil P. Hubbard, Yahya Fiteh, Harissios Vliagoftis, Ing Swie Goping, Dion Brocks, Peter Hwang, Carlos A. Velázquez-Martínez and Shairaz Baksh

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 354-367; DOI: https://doi.org/10.1124/jpet.117.247163
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Antitumor Activity of DLX1008, an Anti-VEGFA Antibody Fragment with Low Picomolar Affinity, in Human Glioma Models
Emese Szabó, Douglas J. Phillips, Miriam Droste, Andrea Marti, Titus Kretzschmar, Abdijapar Shamshiev and Michael Weller

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 422-429; DOI: https://doi.org/10.1124/jpet.117.246249

Endocrine and Diabetes

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Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061
Bryan F. Burkey, Niel C. Hoglen, Philip Inskeep, Margaret Wyman, Thomas E. Hughes and James E. Vath

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 301-313; DOI: https://doi.org/10.1124/jpet.117.246272

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet–Induced Metabolic Dysfunction in Mice
Jackie K. W. Chan, Stefanie Bittner, Alex Bittner, Suman Atwal, Wen-Jun Shen, Mohammed Inayathullah, Jayakumar Rajada, Mark R. Nicolls, Fredric B. Kraemer and Salman Azhar

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 281-290; DOI: https://doi.org/10.1124/jpet.117.243733
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Changes in the Neuronal Control of the Urinary Bladder in a Model of Radiation Cystitis
Daniel Giglio, Lucie Podmolíková and Gunnar Tobin

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 327-335; DOI: https://doi.org/10.1124/jpet.117.246371

Metabolism, Transport, and Pharmacogenomics

Open Access
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor
Nicole A. Kratochwil, Miriam Triyatni, Martina B. Mueller, Florian Klammers, Brian Leonard, Dan Turley, Josephine Schmaler, Aynur Ekiciler, Birgit Molitor, Isabelle Walter, Pierre-Alexis Gonsard, Charles A. Tournillac, Alexandre Durrwell, Michaela Marschmann, Russell Jones, Mohammed Ullah, Franziska Boess, Giorgio Ottaviani, Yuyan Jin, Neil J. Parrott and Stephen Fowler

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 237-248; DOI: https://doi.org/10.1124/jpet.117.245712
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Pharmacokinetic Assessment of Cooperative Efflux of the Multitargeted Kinase Inhibitor Ponatinib Across the Blood-Brain Barrier
Janice K. Laramy, Minjee Kim, Karen E. Parrish, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 249-261; DOI: https://doi.org/10.1124/jpet.117.246116
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Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes
Jamie E. Moscovitz, Amit S. Kalgutkar, Kelly Nulick, Nathaniel Johnson, Zhiwu Lin, Theunis C. Goosen and Yan Weng

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 262-271; DOI: https://doi.org/10.1124/jpet.117.247296
Open Access
Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice
JoEllyn M. McMillan, Denise A. Cobb, Zhiyi Lin, Mary G. Banoub, Raghubendra S. Dagur, Amanda A. Branch Woods, Weimin Wang, Edward Makarov, Ted Kocher, Poonam S. Joshi, Rolen M. Quadros, Donald W. Harms, Samuel M. Cohen, Howard E. Gendelman, Channabasavaiah B. Gurumurthy, Santhi Gorantla and Larisa Y. Poluektova

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 272-280; DOI: https://doi.org/10.1124/jpet.117.247288
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Drug Distribution into Peripheral Nerve
Houfu Liu, Yan Chen, Liang Huang, Xueying Sun, Tingting Fu, Shengqian Wu, Xiaoyan Zhu, Wei Zhen, Jihong Liu, Gang Lu, Wei Cai, Ting Yang, Wandong Zhang, Xiaohong Yu, Zehong Wan, Jianfei Wang, Scott G. Summerfield, Kelly Dong and Georg C. Terstappen

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 336-345; DOI: https://doi.org/10.1124/jpet.117.245613
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Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine
Jie Gao, Zhao Wang, Gao-Ju Wang, Hong-Xin Zhang, Na Gao, Jie Wang, Cai-E. Wang, Zhao Chang, Yan Fang, Yun-Fei Zhang, Jun Zhou, Han Jin and Hai-Ling Qiao

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 398-407; DOI: https://doi.org/10.1124/jpet.117.245555
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Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms
Cen Guo, Carl LaCerte, Jeffrey E. Edwards, Kenneth R. Brouwer and Kim L. R. Brouwer

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 413-421; DOI: https://doi.org/10.1124/jpet.117.246033

Neuropharmacology

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Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA
Thomas F. Gamage, Charlotte E. Farquhar, Timothy W. Lefever, Julie A. Marusich, Richard C. Kevin, Iain S. McGregor, Jenny L. Wiley and Brian F. Thomas

Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 437-446; DOI: https://doi.org/10.1124/jpet.117.246983

Erratum

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Correction to “Amlexanox Inhibits Cerebral Ischemia-Induced Delayed Astrocytic High-Mobility Group Box 1 Release and Subsequent Brain Damage”
Journal of Pharmacology and Experimental Therapeutics May 2018, 365 (2) 226; DOI: https://doi.org/10.1124/jpet.117.245340err

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Table of Contents

Minireviews

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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