Research ArticleDrug Discovery and Translational Medicine
In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor
Ichiro Takasaki, Ai Watanabe, Masafumi Yokai, Yurie Watanabe, Daichi Hayakawa, Ryota Nagashima, Mamoru Fukuchi, Takuya Okada, Naoki Toyooka, Atsuro Miyata, Hiroaki Gouda and Takashi Kurihara
Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 1-8; DOI: https://doi.org/10.1124/jpet.117.245415
Ichiro Takasaki
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Ai Watanabe
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Masafumi Yokai
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Yurie Watanabe
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Daichi Hayakawa
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Ryota Nagashima
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Mamoru Fukuchi
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Takuya Okada
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Naoki Toyooka
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Atsuro Miyata
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Hiroaki Gouda
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
Takashi Kurihara
Department of Pharmacology, Graduate School of Science and Engineering (I.T., A.W., R.N.), Graduate School of Innovative Life Sciences (I.T., T.O., N.T.), Department of Molecular Neurobiology, Graduate School of Medical and Pharmaceutical Sciences (M.F.), and Department of Bio-functional Molecular Engineering, Graduate School of Science and Engineering (T.O., N.T.), University of Toyama, Toyama, Japan; Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan (M.Y., A.M., T.K.); and Department of Analytical and Physical Chemistry, School of Pharmacy, Showa University, Tokyo, Japan (Y.W., D.H., H.G.)
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Research ArticleDrug Discovery and Translational Medicine
Identification of Small-molecule Antagonist of PAC1
Ichiro Takasaki, Ai Watanabe, Masafumi Yokai, Yurie Watanabe, Daichi Hayakawa, Ryota Nagashima, Mamoru Fukuchi, Takuya Okada, Naoki Toyooka, Atsuro Miyata, Hiroaki Gouda and Takashi Kurihara
Journal of Pharmacology and Experimental Therapeutics April 1, 2018, 365 (1) 1-8; DOI: https://doi.org/10.1124/jpet.117.245415
Research ArticleDrug Discovery and Translational Medicine
Identification of Small-molecule Antagonist of PAC1
Ichiro Takasaki, Ai Watanabe, Masafumi Yokai, Yurie Watanabe, Daichi Hayakawa, Ryota Nagashima, Mamoru Fukuchi, Takuya Okada, Naoki Toyooka, Atsuro Miyata, Hiroaki Gouda and Takashi Kurihara
Journal of Pharmacology and Experimental Therapeutics April 1, 2018, 365 (1) 1-8; DOI: https://doi.org/10.1124/jpet.117.245415
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