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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

April 01, 2018; Volume 365,Issue 1

Editorial

  • You have access
    Publishing in an ASPET Journal – What’s in It for You?
    Mary Vore
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 94-95; DOI: https://doi.org/10.1124/jpet.117.248534

Behavioral Pharmacology

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    Repeated Morphine Produces Sensitization to Reward and Tolerance to Antiallodynia in Male and Female Rats with Chemotherapy-Induced Neuropathy
    L. P. Legakis and S. S. Negus
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 9-19; DOI: https://doi.org/10.1124/jpet.117.246215
  • Application of Receptor Theory to the Design and Use of Fixed-Proportion Mu-Opioid Agonist and Antagonist Mixtures in Rhesus Monkeys
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    Application of Receptor Theory to the Design and Use of Fixed-Proportion Mu-Opioid Agonist and Antagonist Mixtures in Rhesus Monkeys
    Jeremy C. Cornelissen, Samuel Obeng, Kenner C. Rice, Yan Zhang, S. Stevens Negus and Matthew L. Banks
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 37-47; DOI: https://doi.org/10.1124/jpet.117.246439

Cardiovascular

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    Toll-Like Receptor 9–Dependent AMPKα Activation Occurs via TAK1 and Contributes to RhoA/ROCK Signaling and Actin Polymerization in Vascular Smooth Muscle Cells
    Cameron G. McCarthy, Camilla F. Wenceslau, Safia Ogbi, Theodora Szasz and R. Clinton Webb
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 60-71; DOI: https://doi.org/10.1124/jpet.117.245746
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    Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2
    Muhamad A. Rostam, Aravindra Shajimoon, Danielle Kamato, Partha Mitra, Terrence J. Piva, Robel Getachew, Yingnan Cao, Wenhua Zheng, Narin Osman and Peter J. Little
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 156-164; DOI: https://doi.org/10.1124/jpet.117.244483

Cellular and Molecular

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    In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183
    Randy S. Schrecengost, Cecelia L. Green, Yan Zhuang, Staci N. Keller, Ryan A. Smith, Lynn W. Maines and Charles D. Smith
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 107-116; DOI: https://doi.org/10.1124/jpet.117.245738

Drug Discovery and Translational Medicine

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    In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor
    Ichiro Takasaki, Ai Watanabe, Masafumi Yokai, Yurie Watanabe, Daichi Hayakawa, Ryota Nagashima, Mamoru Fukuchi, Takuya Okada, Naoki Toyooka, Atsuro Miyata, Hiroaki Gouda and Takashi Kurihara
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 1-8; DOI: https://doi.org/10.1124/jpet.117.245415
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    CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis
    Chenlong Wang, Ying Li, Honglei Chen, Keqing Huang, Xiaoxiao Liu, Miao Qiu, Yanzhuo Liu, Yuqing Yang and Jing Yang
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 72-83; DOI: https://doi.org/10.1124/jpet.117.247130
  • Open Access
    Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice
    Xi Chen, Xiling Jiang, Rajitha Doddareddy, Brian Geist, Thomas McIntosh, William J. Jusko, Honghui Zhou and Weirong Wang
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 140-155; DOI: https://doi.org/10.1124/jpet.117.244855
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    Targeting Glycine Reuptake in Alcohol Seeking and Relapse
    Valentina Vengeliene, Martin Roßmanith, Tatiane T. Takahashi, Daniela Alberati, Berthold Behl, Anton Bespalov and Rainer Spanagel
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 202-211; DOI: https://doi.org/10.1124/jpet.117.244822

Endocrine and Diabetes

  • High N-Acetyltransferase 1 Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 5<em>α</em>-androstane-3<em>β</em>, 17<em>β</em>-Diol, or Dihydrotestosterone in Breast Cancer Cells
    You have access
    High N-Acetyltransferase 1 Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 5α-androstane-3β, 17β-Diol, or Dihydrotestosterone in Breast Cancer Cells
    Xiaoyan Zhang, Samantha M. Carlisle, Mark A. Doll, Robert C. G. Martin, J. Christopher States, Carolyn M. Klinge and David W. Hein
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 84-93; DOI: https://doi.org/10.1124/jpet.117.247031

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Role of the Pregnane X Receptor in Binge Ethanol-Induced Steatosis and Hepatotoxicity
    Sora Choi, Afua A. Gyamfi, Prince Neequaye, Samuel Addo, Frank J. Gonzalez and Maxwell A. Gyamfi
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 165-178; DOI: https://doi.org/10.1124/jpet.117.244665

Inflammation, Immunopharmacology, and Asthma

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    Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP
    Rakesh K. Singh, Leon van Haandel, Daniel P. Heruth, Shui Q. Ye, J. Steven Leeder, Mara L. Becker and Ryan S. Funk
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 96-106; DOI: https://doi.org/10.1124/jpet.117.246199

Metabolism, Transport, and Pharmacogenomics

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    Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites
    Dhilushi D. Wijayakumara, Peter I. Mackenzie, Ross A. McKinnon, Dong Gui Hu and Robyn Meech
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 48-59; DOI: https://doi.org/10.1124/jpet.117.245936

Neuropharmacology

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    Dopamine Receptor Agonist Treatment of Idiopathic Dystonia: A Reappraisal in Humans and Mice
    Xueliang Fan, Yuping Donsante, H. A. Jinnah and Ellen J. Hess
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 20-26; DOI: https://doi.org/10.1124/jpet.117.246348
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    Amlexanox Inhibits Cerebral Ischemia-Induced Delayed Astrocytic High-Mobility Group Box 1 Release and Subsequent Brain Damage
    Sebok Kumar Halder and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 27-36; DOI: https://doi.org/10.1124/jpet.117.245340
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    PARP Inhibition Prevents Ethanol-Induced Neuroinflammatory Signaling and Neurodegeneration in Rat Adult-Age Brain Slice Cultures
    Nuzhath Tajuddin, Hee-Yong Kim and Michael A. Collins
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 117-126; DOI: https://doi.org/10.1124/jpet.117.245290
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    Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist–Induced Rat Models of Schizophrenia
    Masato Nakashima, Haruka Imada, Eri Shiraishi, Yuki Ito, Noriko Suzuki, Maki Miyamoto, Takahiko Taniguchi and Hiroki Iwashita
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 179-188; DOI: https://doi.org/10.1124/jpet.117.245506
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    Curcumin Acts as a Positive Allosteric Modulator of α7-Nicotinic Acetylcholine Receptors and Reverses Nociception in Mouse Models of Inflammatory Pain
    Eslam Gaber El Nebrisi, Deniz Bagdas, Wisam Toma, Halima Al Samri, Anna Brodzik, Yasmin Alkhlaif, Keun-Hang Susan Yang, Frank Christopher Howarth, Imad M. Damaj and Murat Oz
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 190-200; DOI: https://doi.org/10.1124/jpet.117.245068

Toxicology

  • A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation
    Open Access
    A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation
    Andrew K. Smith, Yanli Xu, Glen E. P. Ropella and C. Anthony Hunt
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 127-138; DOI: https://doi.org/10.1124/jpet.117.245019

Errata

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    Correction to “Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect”
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 139; DOI: https://doi.org/10.1124/jpet.117.42754err
  • You have access
    Correction to “High N-Acetyltransferase 1 5α-androstane-3β, Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 17β-Diol, or Dihydrotestosterone in Breast Cancer Cells”
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 189; DOI: https://doi.org/10.1124/jpet.117.247031err
  • You have access
    Correction to “Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2”
    Journal of Pharmacology and Experimental Therapeutics April 2018, 365 (1) 201; DOI: https://doi.org/10.1124/jpet.117.222570err
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Journal of Pharmacology and Experimental Therapeutics: 365 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 365, Issue 1
1 Apr 2018
  • Table of Contents
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