Journal of Pharmacology and Experimental Therapeutics: 364 (3)

March 01, 2018; Volume 364,Issue 3

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Anticancer Activity of Natural and Synthetic Capsaicin Analogs
Jamie R. Friedman, Nicholas A. Nolan, Kathleen C. Brown, Sarah L. Miles, Austin T. Akers, Kate W. Colclough, Jessica M. Seidler, John M. Rimoldi, Monica A. Valentovic and Piyali Dasgupta

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 462-473; DOI: https://doi.org/10.1124/jpet.117.243691

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Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538
Carol A. Paronis, Girish R. Chopda, Kiran Vemuri, Ani S. Zakarian, Alexandros Makriyannis and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 485-493; DOI: https://doi.org/10.1124/jpet.117.245647

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Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently
Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Paul M. Vanhoutte and Mohd Rais Mustafa

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 420-432; DOI: https://doi.org/10.1124/jpet.117.245217

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A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats
Lin Tian, Huan Li, Yan Li, Kun Liu, Yao Sun, Zhongcheng Cong, Xue Luan, Yao Li, Jinglin Chen, Lin Wang, Zhihui Ren, Dengli Cong, Haotian Wang and Jin Pei

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 399-408; DOI: https://doi.org/10.1124/jpet.117.244400
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Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases
Frank Hilberg, Ulrike Tontsch-Grunt, Anke Baum, Anh T. Le, Robert C. Doebele, Simone Lieb, Davide Gianni, Tilman Voss, Pilar Garin-Chesa, Christian Haslinger and Norbert Kraut

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 494-503; DOI: https://doi.org/10.1124/jpet.117.244129

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Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice
Shishun Huang, Bing Zhang, Yingli Chen, Huan Liu, Yang Liu, Xin Li, Zhiwei Bao, Zhenyuan Song and Zhigang Wang

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 452-461; DOI: https://doi.org/10.1124/jpet.117.243105

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Dual Blockade of Interleukin-1β and Interleukin-17A Reduces Murine Arthritis Pathogenesis but Also Leads to Spontaneous Skin Infections in Nonhuman Primates
Melanie C. Ruzek, Lili Huang, Ting- Ting Zhang, Shaughn Bryant, Peter F. Slivka, Carolyn A. Cuff, Catherine Tripp and Guenter Blaich

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 474-484; DOI: https://doi.org/10.1124/jpet.117.243493

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Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug
Yi-an Bi, Sumathy Mathialagan, Laurie Tylaska, Myra Fu, Julie Keefer, Anna Vildhede, Chester Costales, A. David Rodrigues and Manthena V. S. Varma

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 390-398; DOI: https://doi.org/10.1124/jpet.117.245951
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Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart
Eduard Jirkovský, Anna Jirkovská, Jan Bureš, Jaroslav Chládek, Olga Lenčová, Ján Stariat, Zuzana Pokorná, Galina Karabanovich, Jaroslav Roh, Petra Brázdová, Tomáš Šimůnek, Petra Kovaříková and Martin Štěrba

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 433-446; DOI: https://doi.org/10.1124/jpet.117.244848

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Reduction of Motion Sickness Through Targeting Histamine N-Methyltransferase in the Dorsal Vagal Complex of the Brain
Miao-Miao Chen, Li-Hua Xu, Li Chang, Peng Yin and Zheng-Lin Jiang

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 367-376; DOI: https://doi.org/10.1124/jpet.117.244475
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HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production
Akiyoshi Kunugi, Yasukazu Tajima, Haruhiko Kuno, Satoshi Sogabe and Haruhide Kimura

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 377-389; DOI: https://doi.org/10.1124/jpet.117.245050

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Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice
Alyssa F. Collier, Jessica Gumerson, Kimmo Lehtimäki, Jukka Puoliväli, Jace W. Jones, Maureen A. Kane, Sankeerth Manne, Andrea O’Neill, Hillarie P. Windish, Toni Ahtoniemi, Bradley A. Williams, Douglas E. Albrecht and Robert J. Bloch

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 409-419; DOI: https://doi.org/10.1124/jpet.117.244244

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A Comment on “Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression”
Rui Lai, Dehai Xian, Lingyu Yang, Jing Song and Jianqiao Zhong

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 447-448; DOI: https://doi.org/10.1124/jpet.117.246074

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Response to Letter to the Editor on “Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression”
Wendy B. Bollag, Inas Helwa, Vivek Choudhary, Xunsheng Chen and Ismail Kaddour-Djebbar

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 449-451; DOI: https://doi.org/10.1124/jpet.117.246595