Journal of Pharmacology and Experimental Therapeutics: 364 (2)

February 01, 2018; Volume 364,Issue 2

Minireviews

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Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy
Shu-Hui Chuang and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 180-197; DOI: https://doi.org/10.1124/jpet.117.244673
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Etiopathogenesis and Pharmacological Prevention of a Type-2 Diabetes Model in Male Mice
Alberto Loizzo, Santi M. Spampinato, Gabriele Campana and Stefano Loizzo

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 347-358; DOI: https://doi.org/10.1124/jpet.117.244707

Behavioral Pharmacology

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Chronic Δ⁹-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability
William S. John, Thomas J. Martin, Kiran Kumar Solingapuram Sai, Susan H. Nader, H. Donald Gage, Akiva Mintz and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 300-310; DOI: https://doi.org/10.1124/jpet.117.244194
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Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats
Brenda M. Gannon, Agnieszka Sulima, Kenner C. Rice and Gregory T. Collins

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 359-366; DOI: https://doi.org/10.1124/jpet.117.246082

Cardiovascular

Open Access
Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist
Kelly Conlon, Joris H. De Maeyer, Chris Bruce, Jan A. J. Schuurkes, Lee Christie, James McRedmond, Katayoun Derakhchan and Paul R. Wade

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 156-169; DOI: https://doi.org/10.1124/jpet.117.244079
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Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model
Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia J. Filatava, Jun Li, Minglin Zhu, Jose S. Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas and Raouf A. Khalil

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 258-274; DOI: https://doi.org/10.1124/jpet.117.244798

Cellular and Molecular

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A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells
Yuhong Jiang, Mei-Kwan Yau, Junxian Lim, Kai-Chen Wu, Weijun Xu, Jacky Y. Suen and David P. Fairlie

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 246-257; DOI: https://doi.org/10.1124/jpet.117.245027

Drug Discovery and Translational Medicine

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A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration
Tivadar Orban, Henri Leinonen, Tamar Getter, Zhiqian Dong, Wenyu Sun, Songqi Gao, Alexander Veenstra, Hossein Heidari-Torkabadi, Timothy S. Kern, Philip D. Kiser and Krzysztof Palczewski

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 207-220; DOI: https://doi.org/10.1124/jpet.117.245167
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Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis
Megan McGrath, Celena Ma and Douglas E. Raines

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 229-237; DOI: https://doi.org/10.1124/jpet.117.245332
Open Access
Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility
Nobuyuki Takahashi and Yukinori Take

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 275-286; DOI: https://doi.org/10.1124/jpet.117.244202
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Inhibition of Myeloperoxidase by N-Acetyl Lysyltyrosylcysteine Amide Reduces Oxidative Stress–Mediated Inflammation, Neuronal Damage, and Neural Stem Cell Injury in a Murine Model of Stroke
Guoliang Yu, Ye Liang, Shikan Zheng and Hao Zhang

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 311-322; DOI: https://doi.org/10.1124/jpet.117.245688
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Cancer Stem Cell–Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum
Narumol Bhummaphan, Varisa Pongrakhananon, Boonchoo Sritularak and Pithi Chanvorachote

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 332-346; DOI: https://doi.org/10.1124/jpet.117.244467

Endocrine and Diabetes

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Restoration of Rostral Ventrolateral Medulla Cystathionine-γ Lyase Activity Underlies Moxonidine-Evoked Neuroprotection and Sympathoinhibition in Diabetic Rats
Mohamed A. Fouda, Shaimaa S. El-Sayed and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 170-178; DOI: https://doi.org/10.1124/jpet.117.243865

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury
Jeffrey D. Pressly, Suni M. Mustafa, Ammaar H. Abidi, Sahar Alghamdi, Pankaj Pandey, Kuldeep K. Roy, Robert J. Doerksen, Bob M. Moore and Frank Park

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 287-299; DOI: https://doi.org/10.1124/jpet.117.245522

Inflammation, Immunopharmacology, and Asthma

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Adenosine A_2A Receptor Agonist, 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine Hydrochloride Hydrate, Inhibits Inflammation and Increases Fibroblast Growth Factor-2 Tissue Expression in Carrageenan-Induced Rat Paw Edema
Armando Ialenti, Elisabetta Caiazzo, Silvana Morello, Rosa Carnuccio and Carla Cicala

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 221-228; DOI: https://doi.org/10.1124/jpet.117.244319

Metabolism, Transport, and Pharmacogenomics

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Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways
Taraneh Taghavi, Christopher A. Arger, Sarah H. Heil, Stephen T. Higgins and Rachel F. Tyndale

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 238-245; DOI: https://doi.org/10.1124/jpet.117.245126
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Low-Dose Anthracycline and Risk of Heart Failure in a Pharmacokinetic Model of Human Myocardium Exposure: Analog Specificity and Role of Secondary Alcohol Metabolites
Emanuela Salvatorelli, Pierantonio Menna, Massimo Chello, Elvio Covino and Giorgio Minotti

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 323-331; DOI: https://doi.org/10.1124/jpet.117.246140

Neuropharmacology

Open Access
Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia
Michele Morari, Alberto Brugnoli, Clarissa Anna Pisanò, Salvatore Novello, Carla Caccia, Elsa Melloni, Gloria Padoani, Silvia Vailati and Marco Sardina

Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 198-206; DOI: https://doi.org/10.1124/jpet.117.245100

Erratum

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Correction to “Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress”
Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 179; DOI: https://doi.org/10.1124/jpet.117.243717err

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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