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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2018; Volume 364,Issue 2

Minireviews

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    Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy
    Shu-Hui Chuang and Doodipala Samba Reddy
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 180-197; DOI: https://doi.org/10.1124/jpet.117.244673
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    Etiopathogenesis and Pharmacological Prevention of a Type-2 Diabetes Model in Male Mice
    Alberto Loizzo, Santi M. Spampinato, Gabriele Campana and Stefano Loizzo
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 347-358; DOI: https://doi.org/10.1124/jpet.117.244707

Behavioral Pharmacology

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    Chronic Δ9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability
    William S. John, Thomas J. Martin, Kiran Kumar Solingapuram Sai, Susan H. Nader, H. Donald Gage, Akiva Mintz and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 300-310; DOI: https://doi.org/10.1124/jpet.117.244194
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    Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats
    Brenda M. Gannon, Agnieszka Sulima, Kenner C. Rice and Gregory T. Collins
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 359-366; DOI: https://doi.org/10.1124/jpet.117.246082

Cardiovascular

  • Open Access
    Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist
    Kelly Conlon, Joris H. De Maeyer, Chris Bruce, Jan A. J. Schuurkes, Lee Christie, James McRedmond, Katayoun Derakhchan and Paul R. Wade
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 156-169; DOI: https://doi.org/10.1124/jpet.117.244079
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    Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model
    Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia J. Filatava, Jun Li, Minglin Zhu, Jose S. Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas and Raouf A. Khalil
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 258-274; DOI: https://doi.org/10.1124/jpet.117.244798

Cellular and Molecular

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    A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells
    Yuhong Jiang, Mei-Kwan Yau, Junxian Lim, Kai-Chen Wu, Weijun Xu, Jacky Y. Suen and David P. Fairlie
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 246-257; DOI: https://doi.org/10.1124/jpet.117.245027

Drug Discovery and Translational Medicine

  • A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration
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    A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration
    Tivadar Orban, Henri Leinonen, Tamar Getter, Zhiqian Dong, Wenyu Sun, Songqi Gao, Alexander Veenstra, Hossein Heidari-Torkabadi, Timothy S. Kern, Philip D. Kiser and Krzysztof Palczewski
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 207-220; DOI: https://doi.org/10.1124/jpet.117.245167
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    Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis
    Megan McGrath, Celena Ma and Douglas E. Raines
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 229-237; DOI: https://doi.org/10.1124/jpet.117.245332
  • Open Access
    Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility
    Nobuyuki Takahashi and Yukinori Take
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 275-286; DOI: https://doi.org/10.1124/jpet.117.244202
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    Inhibition of Myeloperoxidase by N-Acetyl Lysyltyrosylcysteine Amide Reduces Oxidative Stress–Mediated Inflammation, Neuronal Damage, and Neural Stem Cell Injury in a Murine Model of Stroke
    Guoliang Yu, Ye Liang, Shikan Zheng and Hao Zhang
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 311-322; DOI: https://doi.org/10.1124/jpet.117.245688
  • Cancer Stem Cell–Suppressing Activity of Chrysotoxine, a Bibenzyl from <em>Dendrobium pulchellum</em>
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    Cancer Stem Cell–Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum
    Narumol Bhummaphan, Varisa Pongrakhananon, Boonchoo Sritularak and Pithi Chanvorachote
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 332-346; DOI: https://doi.org/10.1124/jpet.117.244467

Endocrine and Diabetes

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    Restoration of Rostral Ventrolateral Medulla Cystathionine-γ Lyase Activity Underlies Moxonidine-Evoked Neuroprotection and Sympathoinhibition in Diabetic Rats
    Mohamed A. Fouda, Shaimaa S. El-Sayed and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 170-178; DOI: https://doi.org/10.1124/jpet.117.243865

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury
    Jeffrey D. Pressly, Suni M. Mustafa, Ammaar H. Abidi, Sahar Alghamdi, Pankaj Pandey, Kuldeep K. Roy, Robert J. Doerksen, Bob M. Moore and Frank Park
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 287-299; DOI: https://doi.org/10.1124/jpet.117.245522

Inflammation, Immunopharmacology, and Asthma

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    Adenosine A2A Receptor Agonist, 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine Hydrochloride Hydrate, Inhibits Inflammation and Increases Fibroblast Growth Factor-2 Tissue Expression in Carrageenan-Induced Rat Paw Edema
    Armando Ialenti, Elisabetta Caiazzo, Silvana Morello, Rosa Carnuccio and Carla Cicala
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 221-228; DOI: https://doi.org/10.1124/jpet.117.244319

Metabolism, Transport, and Pharmacogenomics

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    Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways
    Taraneh Taghavi, Christopher A. Arger, Sarah H. Heil, Stephen T. Higgins and Rachel F. Tyndale
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 238-245; DOI: https://doi.org/10.1124/jpet.117.245126
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    Low-Dose Anthracycline and Risk of Heart Failure in a Pharmacokinetic Model of Human Myocardium Exposure: Analog Specificity and Role of Secondary Alcohol Metabolites
    Emanuela Salvatorelli, Pierantonio Menna, Massimo Chello, Elvio Covino and Giorgio Minotti
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 323-331; DOI: https://doi.org/10.1124/jpet.117.246140

Neuropharmacology

  • Open Access
    Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia
    Michele Morari, Alberto Brugnoli, Clarissa Anna Pisanò, Salvatore Novello, Carla Caccia, Elsa Melloni, Gloria Padoani, Silvia Vailati and Marco Sardina
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 198-206; DOI: https://doi.org/10.1124/jpet.117.245100

Erratum

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    Correction to “Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress”
    Journal of Pharmacology and Experimental Therapeutics February 2018, 364 (2) 179; DOI: https://doi.org/10.1124/jpet.117.243717err
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Journal of Pharmacology and Experimental Therapeutics: 364 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 364, Issue 2
1 Feb 2018
  • Table of Contents
  • Table of Contents (PDF)
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  • Metabolism, Transport, and Pharmacogenomics
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