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Research ArticleDrug Discovery and Translational Medicine

The Anti–Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo

Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal and Grazia Graziani
Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 77-86; DOI: https://doi.org/10.1124/jpet.117.244434
Maria Grazia Atzori
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Lucio Tentori
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Federica Ruffini
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Claudia Ceci
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Elena Bonanno
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Manuel Scimeca
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Pedro Miguel Lacal
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Grazia Graziani
Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
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Article Information

vol. 364 no. 1 77-86
DOI 
https://doi.org/10.1124/jpet.117.244434
PubMed 
29025978

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 4, 2017
  • Accepted October 10, 2017
  • Published online December 19, 2017.

Article Versions

  • Earlier version (October 12, 2017 - 10:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Maria Grazia Atzori1,
  2. Lucio Tentori1,
  3. Federica Ruffini,
  4. Claudia Ceci,
  5. Elena Bonanno,
  6. Manuel Scimeca,
  7. Pedro Miguel Lacal2, and
  8. Grazia Graziani2
  1. Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)
  1. Address correspondence to:
    Grazia Graziani, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. E-mail: graziani{at}uniroma2.it; or Pedro Miguel Lacal, Laboratory of Molecular Oncology, “Istituto Dermopatico dell’Immacolata”-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy. E-mail: p.lacal{at}idi.it
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Journal of Pharmacology and Experimental Therapeutics: 364 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 364, Issue 1
1 Jan 2018
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Research ArticleDrug Discovery and Translational Medicine

In Vivo Antiglioma Activity of a Novel Anti–VEGFR-1 mAb

Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal and Grazia Graziani
Journal of Pharmacology and Experimental Therapeutics January 1, 2018, 364 (1) 77-86; DOI: https://doi.org/10.1124/jpet.117.244434

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Research ArticleDrug Discovery and Translational Medicine

In Vivo Antiglioma Activity of a Novel Anti–VEGFR-1 mAb

Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal and Grazia Graziani
Journal of Pharmacology and Experimental Therapeutics January 1, 2018, 364 (1) 77-86; DOI: https://doi.org/10.1124/jpet.117.244434
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