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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2018; Volume 364,Issue 1

Minireviews

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    MicroRNA-Directed Cancer Therapies: Implications in Melanoma Intervention
    Anita Thyagarajan, Ahmed Shaban and Ravi Prakash Sahu
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 1-12; DOI: https://doi.org/10.1124/jpet.117.242636

Cardiovascular

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    Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress
    R. Jason Kirby, Daniela B. Divlianska, Kanupriya Whig, Nadezda Bryan, Camilo J. Morfa, Ada Koo, Becky L. Hood, Kevin H. Nguyen, Patrick Maloney, Satayamaheshwar Peddibhotla, E. Hampton Sessions, Paul M. Hershberger, Layton H. Smith and Siobhan Malany
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 87-96; DOI: https://doi.org/10.1124/jpet.117.243717

Chemotherapy, Antibiotics, and Gene Therapy

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    Pharmacokinetic/Pharmacodynamic Modeling of Schedule-Dependent Interaction between Docetaxel and Cabozantinib in Human Prostate Cancer Xenograft Models
    Wenjun Chen, Rong Chen, Jian Li, Yu Fu, Liang Yang, Hong Su, Ye Yao, Liang Li, Tianyan Zhou and Wei Lu
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 13-25; DOI: https://doi.org/10.1124/jpet.117.243931
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    Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN
    S. Lauren Kyte, Wisam Toma, Deniz Bagdas, Julie A. Meade, Lesley D. Schurman, Aron H. Lichtman, Zhi-Jian Chen, Egidio Del Fabbro, Xianjun Fang, John W. Bigbee, M. Imad Damaj and David A. Gewirtz
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 110-119; DOI: https://doi.org/10.1124/jpet.117.243972

Drug Discovery and Translational Medicine

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    Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro
    Susanne Neumann, Elena Eliseeva, Alisa Boutin, Elena Barnaeva, Marc Ferrer, Noel Southall, David Kim, Xin Hu, Sarah J. Morgan, Juan J. Marugan and Marvin C. Gershengorn
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 38-45; DOI: https://doi.org/10.1124/jpet.117.244095
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    Synergistic Antiproliferative Activity of the RAD51 Inhibitor IBR2 with Inhibitors of Receptor Tyrosine Kinases and Microtubule Protein
    Peter J. Ferguson, Mark D. Vincent and James Koropatnick
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 46-54; DOI: https://doi.org/10.1124/jpet.117.241661
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    Melatonin Receptor Agonist Piromelatine Ameliorates Impaired Glucose Metabolism in Chronically Stressed Rats Fed a High-Fat Diet
    Jun Zhou, Deng Wang, XiaoHong Luo, Xu Jia, MaoXing Li, Moshe Laudon, RuXue Zhang and ZhengPing Jia
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 55-69; DOI: https://doi.org/10.1124/jpet.117.243998
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    The Anti–Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo
    Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal and Grazia Graziani
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 77-86; DOI: https://doi.org/10.1124/jpet.117.244434
  • Open Access
    INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies
    Niu Shin, Yun-Long Li, Song Mei, Kathy He Wang, Leslie Hall, Kamna Katiyar, Qian Wang, Gengjie Yang, Beth Rumberger, Lynn Leffet, Xin He, Mark Rupar, Kevin Bowman, Margaret Favata, Jun Li, Mike Liu, Yanlong Li, Maryanne Covington, Holly Koblish, Maxim Soloviev, Dana Shuey, Timothy Burn, Sharon Diamond, Jordan Fridman, Andrew Combs, Wenqing Yao, Swamy Yeleswaram, Gregory Hollis, Kris Vaddi, Reid Huber, Robert Newton and Peggy Scherle
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 120-130; DOI: https://doi.org/10.1124/jpet.117.244947

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    KV7 Channel Pharmacological Activation by the Novel Activator ML213: Role for Heteromeric KV7.4/KV7.5 Channels in Guinea Pig Detrusor Smooth Muscle Function
    Aaron Provence, Damiano Angoli and Georgi V. Petkov
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 131-144; DOI: https://doi.org/10.1124/jpet.117.243162

Neuropharmacology

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    An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction
    Emi Kurimoto, Satoru Matsuda, Yuji Shimizu, Yuu Sako, Takao Mandai, Takahiro Sugimoto, Hiroki Sakamoto and Haruhide Kimura
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 28-37; DOI: https://doi.org/10.1124/jpet.117.243774
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    Single Channel Analysis of Isoflurane and Ethanol Enhancement of Taurine-Activated Glycine Receptors
    Dean Kirson, Jelena Todorovic and S. John Mihic
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 70-76; DOI: https://doi.org/10.1124/jpet.117.243840
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    Epigenetic Histone Deacetylation Inhibition Prevents the Development and Persistence of Temporal Lobe Epilepsy
    Sandesh D. Reddy, Bryan L. Clossen and Doodipala Samba Reddy
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 97-109; DOI: https://doi.org/10.1124/jpet.117.244939
  • Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens
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    Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens
    Scott A. Schelp, Zachary D. Brodnik, Dylan R. Rakowski, Katherine J. Pultorak, Asha T. Sambells, Rodrigo A. España and Erik B. Oleson
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 145-155; DOI: https://doi.org/10.1124/jpet.117.241802

Erratum

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    Correction to “TD-19, an Erlotinib Derivative, Induces Epidermal Growth Factor Receptor Wild-Type Nonsmall-Cell Lung Cancer Apoptosis through CIP2A-Mediated Pathway”
    Journal of Pharmacology and Experimental Therapeutics January 2018, 364 (1) 26-27; DOI: https://doi.org/10.1124/jpet.117.215418err
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 364 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 364, Issue 1
1 Jan 2018
  • Table of Contents
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