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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 2017; Volume 363,Issue 3

Minireviews

  • You have access
    Mitochondrial-Based Therapeutics for the Treatment of Spinal Cord Injury: Mitochondrial Biogenesis as a Potential Pharmacological Target
    Natalie E. Scholpa and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 303-313; DOI: https://doi.org/10.1124/jpet.117.244806

Behavioral Pharmacology

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    Cannabinoid CB1 Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors
    Michael Z. Leonard, Shakiru O. Alapafuja, Lipin Ji, Vidyanand G. Shukla, Yingpeng Liu, Spyros P. Nikas, Alexandros Makriyannis, Jack Bergman and Brian D. Kangas
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 314-323; DOI: https://doi.org/10.1124/jpet.117.244392
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    Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model
    Jenny L. Wilkerson, Giulia Donvito, Travis W. Grim, Rehab A. Abdullah, Daisuke Ogasawara, Benjamin F. Cravatt and Aron H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 394-401; DOI: https://doi.org/10.1124/jpet.117.243808

Cardiovascular

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    Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia
    Jennifer L. Ariazi, Kevin J. Duffy, David F. Adams, Duke M. Fitch, Lusong Luo, Melissa Pappalardi, Mangatt Biju, Erin Hugger DiFilippo, Tony Shaw, Ken Wiggall and Connie Erickson-Miller
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 336-347; DOI: https://doi.org/10.1124/jpet.117.242503
  • Open Access
    Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug
    Michel R. Corboz, Zhili Li, Vladimir Malinin, Adam J. Plaunt, Donna M. Konicek, Franziska G. Leifer, Kuan-Ju Chen, Charles E. Laurent, Han Yin, Marzena C. Biernat, Dany Salvail, Jianguo Zhuang, Fadi Xu, Aidan Curran, Walter R. Perkins and Richard W. Chapman
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 348-357; DOI: https://doi.org/10.1124/jpet.117.242099
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    Sustained Activation of Guanylate Cyclase-A with TDT, a Natriuretic Peptide Derivative, Exhibits Cardiorenal Protection in Dahl Salt-Sensitive Hypertensive Rats
    Shohei Oishi, Naoko Suzuki, Yuri Hasui, Tsuyoshi Homma, Masanori Obana, Takahiro Nagayama and Yasushi Fujio
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 402-410; DOI: https://doi.org/10.1124/jpet.117.244459
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    The Blood Pressure–Lowering Effect of 20-HETE Blockade in Cyp4a14(−/−) Mice Is Associated with Natriuresis
    Varunkumar Pandey, Victor Garcia, Ankit Gilani, Priyanka Mishra, Frank Fan Zhang, Mahesh P. Paudyal, John R. Falck, Alberto Nasjletti, Wen-Hui Wang and Michal Laniado Schwartzman
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 412-418; DOI: https://doi.org/10.1124/jpet.117.243618

Cellular and Molecular

  • Extracellular Signal–Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury
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    Extracellular Signal–Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury
    Justin B. Collier and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 419-427; DOI: https://doi.org/10.1124/jpet.117.244152

Chemotherapy, Antibiotics, and Gene Therapy

  • Activation of Focal Adhesion Kinase and Src Mediates Acquired Sorafenib Resistance in A549 Human Lung Adenocarcinoma Xenografts
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    Activation of Focal Adhesion Kinase and Src Mediates Acquired Sorafenib Resistance in A549 Human Lung Adenocarcinoma Xenografts
    Qingyu Zhou, Xiaofang Guo and Riya Choksi
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 428-443; DOI: https://doi.org/10.1124/jpet.117.240507

Drug Discovery and Translational Medicine

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    Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes
    Elizabeth A. Rondini, Ljiljana Mladenovic-Lucas, William R. Roush, Geoff T. Halvorsen, Alex E. Green and James G. Granneman
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 367-376; DOI: https://doi.org/10.1124/jpet.117.243253

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    8-Aminoguanosine Exerts Diuretic, Natriuretic, and Glucosuric Activity via Conversion to 8-Aminoguanine, Yet Has Direct Antikaliuretic Effects
    Edwin K. Jackson and Zaichuan Mi
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 358-366; DOI: https://doi.org/10.1124/jpet.117.243758
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    Creation of a Claudin-2 Binder and Its Tight Junction–Modulating Activity in a Human Intestinal Model
    Mutsumi Takigawa, Manami Iida, Shotaro Nagase, Hidehiko Suzuki, Akihiro Watari, Minoru Tada, Yoshiaki Okada, Takefumi Doi, Masayoshi Fukasawa, Kiyohito Yagi, Jun Kunisawa and Masuo Kondoh
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 444-451; DOI: https://doi.org/10.1124/jpet.117.242214

Metabolism, Transport, and Pharmacogenomics

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    Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier
    Sana-Kay Whyte-Allman, Md Tozammel Hoque, Mohammad-Ali Jenabian, Jean-Pierre Routy and Reina Bendayan
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 324-335; DOI: https://doi.org/10.1124/jpet.117.243584

Neuropharmacology

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    Treatment with Sulforaphane Produces Antinociception and Improves Morphine Effects during Inflammatory Pain in Mice
    Alejandro Redondo, Pablo Aníbal Ferreira Chamorro, Gabriela Riego, Sergi Leánez and Olga Pol
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 293-302; DOI: https://doi.org/10.1124/jpet.117.244376
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    Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
    Linda J. Bristow, Jyoti Gulia, Michael R. Weed, Bettadapura N. Srikumar, Yu-Wen Li, John D. Graef, Pattipati S. Naidu, Charulatha Sanmathi, Jayant Aher, Tanmaya Bastia, Mahesh Paschapur, Narasimharaju Kalidindi, Kuchibhotla Vijaya Kumar, Thaddeus Molski, Rick Pieschl, Alda Fernandes, Jeffrey M. Brown, Digavalli V. Sivarao, Kimberly Newberry, Mark Bookbinder, Joseph Polino, Deborah Keavy, Amy Newton, Eric Shields, Jean Simmermacher, James Kempson, Jianqing Li, Huiping Zhang, Arvind Mathur, Raja Reddy Kallem, Meenakshee Sinha, Manjunath Ramarao, Reeba K. Vikramadithyan, Srinivasan Thangathirupathy, Jayakumar Warrier, Imadul Islam, Joanne J. Bronson, Richard E. Olson, John E. Macor, Charlie F. Albright, Dalton King, Lorin A. Thompson, Lawrence R. Marcin and Michael Sinz
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 377-393; DOI: https://doi.org/10.1124/jpet.117.242784

Erratum

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    Correction to “8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity”
    Journal of Pharmacology and Experimental Therapeutics December 2017, 363 (3) 411; DOI: https://doi.org/10.1124/jpet.114.237552err
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Journal of Pharmacology and Experimental Therapeutics: 363 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 363, Issue 3
1 Dec 2017
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