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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2017; Volume 363,Issue 2

Minireviews

  • You have access
    Factors Contributing to the Antiviral Effectiveness of Tenofovir
    Rachel A. Murphy and Monica A. Valentovic
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 156-163; DOI: https://doi.org/10.1124/jpet.117.243139
  • You have access
    Cellular and Molecular Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II in Chronic Pain
    Ya-Qun Zhou, Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xue-Rong Zhou, Fang Luo, Yu-Ke Tian and Da-Wei Ye
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 176-183; DOI: https://doi.org/10.1124/jpet.117.243048

Cardiovascular

  • Open Access
    Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca2+ Channels
    Changbo Zheng, Mingkui Zhong, Zenghua Qi, Fan Shen, Qiannan Zhao, Lulu Wu, Yu Huang, Suk-Ying Tsang and Xiaoqiang Yao
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 211-220; DOI: https://doi.org/10.1124/jpet.117.242685

Cellular and Molecular

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    Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons
    Francesca Longhena, Michela Zaltieri, Jessica Grigoletto, Gaia Faustini, Luca La Via, Roberta Ghidoni, Luisa Benussi, Cristina Missale, PierFranco Spano and Arianna Bellucci
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 164-175; DOI: https://doi.org/10.1124/jpet.117.242164
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    A Model of the Block of Voltage-Gated Potassium Kv4.2 Ionic Currents by 4-Aminopyridine
    Steven J. Kehl
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 184-195; DOI: https://doi.org/10.1124/jpet.117.243097
  • You have access
    Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model
    Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi and Masuo Kondoh
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 275-283; DOI: https://doi.org/10.1124/jpet.117.243014

Chemotherapy, Antibiotics, and Gene Therapy

  • Hybrid of DNA-targeting Chlorambucil with Pt(IV) Species to Reverse Drug Resistance
    You have access
    Hybrid of DNA-targeting Chlorambucil with Pt(IV) Species to Reverse Drug Resistance
    Feihong Chen, Gang Xu, Xiaodong Qin, Xiufeng Jin and Shaohua Gou
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 221-239; DOI: https://doi.org/10.1124/jpet.117.243451

Drug Discovery and Translational Medicine

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    Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma
    Janice K. Laramy, Minjee Kim, Shiv K. Gupta, Karen E. Parrish, Shuangling Zhang, Katrina K. Bakken, Brett L. Carlson, Ann C. Mladek, Daniel J. Ma, Jann N. Sarkaria and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 136-147; DOI: https://doi.org/10.1124/jpet.117.243477
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    Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells
    Steven R. Hall, Jay Toulany, Leah G. Bennett, Camilo F. Martinez-Farina, Andrew W. Robertson, David L. Jakeman and Kerry B. Goralski
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 196-210; DOI: https://doi.org/10.1124/jpet.117.241125
  • Open Access
    Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
    Tjeerd Barf, Todd Covey, Raquel Izumi, Bas van de Kar, Michael Gulrajani, Bart van Lith, Maaike van Hoek, Edwin de Zwart, Diana Mittag, Dennis Demont, Saskia Verkaik, Fanny Krantz, Paul G. Pearson, Roger Ulrich and Allard Kaptein
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 240-252; DOI: https://doi.org/10.1124/jpet.117.242909

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • You have access
    Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis
    Marlies Schippers, Leonie Beljaars, Eduard Post, Sophie Lotersztajn, Catharina Reker-Smit, Bing Han, Pablo Munoz-Llancao, Martina Schmidt and Klaas Poelstra
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 126-135; DOI: https://doi.org/10.1124/jpet.117.241646

Metabolism, Transport, and Pharmacogenomics

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    Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver
    Meijuan Xu, Deepak Kumar Bhatt, Catherine K. Yeung, Katrina G. Claw, Amarjit S. Chaudhry, Andrea Gaedigk, Robin E. Pearce, Ulrich Broeckel, Roger Gaedigk, Deborah A. Nickerson, Erin Schuetz, Allan E. Rettie, J. Steven Leeder, Kenneth E. Thummel and Bhagwat Prasad
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 265-274; DOI: https://doi.org/10.1124/jpet.117.243113

Neuropharmacology

  • Open Access
    Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum
    Kelly E. Bosse, Max F. Oginsky, Laura L. Susick, Sailesh Ramalingam, Carrie R. Ferrario and Alana C. Conti
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 148-155; DOI: https://doi.org/10.1124/jpet.117.242321
  • You have access
    FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia
    Keiji Nishiyama, Hirobumi Suzuki, Toshiya Harasawa, Noriko Suzuki, Emi Kurimoto, Takayuki Kawai, Minoru Maruyama, Hidetoshi Komatsu, Kensuke Sakuma, Yuji Shimizu and Masato Shimojo
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 253-264; DOI: https://doi.org/10.1124/jpet.117.242925
  • You have access
    A Novel Bibenzyl Compound (20C) Protects Mice from 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine/Probenecid Toxicity by Regulating the α-Synuclein–Related Inflammatory Response
    Qiu-Shuang Zhang, Yang Heng, Ying Chen, Piao Luo, Lu Wen, Zhao Zhang, Yu-He Yuan and Nai-Hong Chen
    Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 284-292; DOI: https://doi.org/10.1124/jpet.117.244020
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Journal of Pharmacology and Experimental Therapeutics: 363 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 363, Issue 2
1 Nov 2017
  • Table of Contents
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