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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2017; Volume 363,Issue 1

Minireviews

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    Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers
    Natalie A. Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G. McLaren, Thomas P. Roddy, Douglas G. Johns, Denise Milot, Takhar Kasumov, Mark D. Erion, David E. Kelley and Stephen F. Previs
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 80-91; DOI: https://doi.org/10.1124/jpet.117.241091

Behavioral Pharmacology

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    Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential
    A. J. Brock, S. M. G. Goody, A. N. Mead, A. Sudwarts, M.O. Parker and C.H. Brennan
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 66-79; DOI: https://doi.org/10.1124/jpet.117.242628

Cardiovascular

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    Docetaxel Reverses Pulmonary Vascular Remodeling by Decreasing Autophagy and Resolves Right Ventricular Fibrosis
    Yasmine F. Ibrahim, Nataliia V. Shults, Vladyslava Rybka and Yuichiro J. Suzuki
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 20-34; DOI: https://doi.org/10.1124/jpet.117.239921

Cellular and Molecular

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    CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome
    Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, Françoise Bachelerie and Martine J. Smit
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 35-44; DOI: https://doi.org/10.1124/jpet.117.242735

Chemotherapy, Antibiotics, and Gene Therapy

  • Open Access
    Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites
    De Lin, Rumen Kostov, Jeffrey T.-J. Huang, Colin J. Henderson and C. Roland Wolf
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 12-19; DOI: https://doi.org/10.1124/jpet.117.243246

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    New Peptide Inhibitor of Dipeptidyl Peptidase IV, EMDB-1 Extends the Half-Life of GLP-2 and Attenuates Colitis in Mice after Topical Administration
    Maciej Salaga, Anna Mokrowiecka, Marta Zielinska, Ewa Malecka-Panas, Radzislaw Kordek, Elzbieta Kamysz and Jakub Fichna
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 92-103; DOI: https://doi.org/10.1124/jpet.117.242586
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    Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress
    John G. Yonchuk, Joseph P. Foley, Brian J. Bolognese, Gregory Logan, William E. Wixted, Jen-Pyng Kou, Diana G. Chalupowicz, Heidi G. Feldser, Yolanda Sanchez, Hong Nie, James F. Callahan, Jeffrey K. Kerns and Patricia L. Podolin
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 114-125; DOI: https://doi.org/10.1124/jpet.117.241794

Metabolism, Transport, and Pharmacogenomics

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    Mechanistic Multi—Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics
    Vivaswath S. Ayyar, Debra C. DuBois, Richard R. Almon and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 45-57; DOI: https://doi.org/10.1124/jpet.117.242990

Neuropharmacology

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    Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons
    John Peyton Bohnsack, Vraj K. Patel and A. Leslie Morrow
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 1-11; DOI: https://doi.org/10.1124/jpet.117.242446

Toxicology

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    Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model
    Melissa Guada, Raghu Ganugula, Manicka Vadhanam and Majeti N.V. Ravi Kumar
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 58-65; DOI: https://doi.org/10.1124/jpet.117.242420
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    NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential
    Takahiro Miyazaki, Irene Y. Choi, Werner Rubas, Neel K. Anand, Cherie Ali, Juli Evans, Hema Gursahani, Marlene Hennessy, Grace Kim, Daniel McWeeney, Juergen Pfeiffer, Phi Quach, David Gauvin, Timothy A. Riley, Jennifer A. Riggs, Kathleen Gogas, Jonathan Zalevsky and Stephen K. Doberstein
    Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 104-113; DOI: https://doi.org/10.1124/jpet.117.243030
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 363 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 363, Issue 1
1 Oct 2017
  • Table of Contents
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