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Research ArticleMinireview

Pleiotropic and Adverse Effects of Statins—Do Epigenetics Play a Role?

Stephanie C. Allen and Cyril D.S. Mamotte
Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 319-326; DOI: https://doi.org/10.1124/jpet.117.242081
Stephanie C. Allen
School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia
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Cyril D.S. Mamotte
School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia
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Article Information

vol. 362 no. 2 319-326
DOI 
https://doi.org/10.1124/jpet.117.242081
PubMed 
28576976

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 10, 2017
  • Accepted May 23, 2017
  • Published online July 18, 2017.

Article Versions

  • Earlier version (June 2, 2017 - 12:55).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephanie C. Allen and
  2. Cyril D.S. Mamotte
  1. School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia
  1. Address correspondence to:
    Cyril Mamotte, School of Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, GPO Box U1987, Perth, Western Australia, 6845. E-mail: C.Mamotte{at}curtin.edu.au
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Journal of Pharmacology and Experimental Therapeutics: 362 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 362, Issue 2
1 Aug 2017
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Research ArticleMinireview

Epigenetic Effects of Statins

Stephanie C. Allen and Cyril D.S. Mamotte
Journal of Pharmacology and Experimental Therapeutics August 1, 2017, 362 (2) 319-326; DOI: https://doi.org/10.1124/jpet.117.242081

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Research ArticleMinireview

Epigenetic Effects of Statins

Stephanie C. Allen and Cyril D.S. Mamotte
Journal of Pharmacology and Experimental Therapeutics August 1, 2017, 362 (2) 319-326; DOI: https://doi.org/10.1124/jpet.117.242081
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  • Article
    • Abstract
    • Introduction
    • The Nature of Epigenetic Modifications
    • Epigenetic Effects of Statins
    • Epigenetics as a Mechanism for the Pleiotropic Effects of Statins
    • Epigenetics in Liver and Muscle Toxicity
    • Conclusion
    • Authorship Contributions
    • Footnotes
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    • References
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