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Research ArticleDrug Discovery and Translational Medicine
Open Access

In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist

Carsten Theodor Beuckmann, Michiyuki Suzuki, Takashi Ueno, Kazuya Nagaoka, Tohru Arai and Hiroyuki Higashiyama
Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 287-295; DOI: https://doi.org/10.1124/jpet.117.241422
Carsten Theodor Beuckmann
Neurology Business Group, Discovery (C.T.B.), Drug Metabolism and Pharmacokinetics (T.U.), hhc Data Creation Center (K.N.), and Medicine Development Center (T.A.), Eisai Co., Ltd., Tsukuba, Ibaraki, Japan; and Global Regulatory Affairs (M.S.), Neurology Business Group (H.H.), Japan and Asia Clinical Development, Eisai Co., Ltd., Bunkyo, Tokyo, Japan
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Michiyuki Suzuki
Neurology Business Group, Discovery (C.T.B.), Drug Metabolism and Pharmacokinetics (T.U.), hhc Data Creation Center (K.N.), and Medicine Development Center (T.A.), Eisai Co., Ltd., Tsukuba, Ibaraki, Japan; and Global Regulatory Affairs (M.S.), Neurology Business Group (H.H.), Japan and Asia Clinical Development, Eisai Co., Ltd., Bunkyo, Tokyo, Japan
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Takashi Ueno
Neurology Business Group, Discovery (C.T.B.), Drug Metabolism and Pharmacokinetics (T.U.), hhc Data Creation Center (K.N.), and Medicine Development Center (T.A.), Eisai Co., Ltd., Tsukuba, Ibaraki, Japan; and Global Regulatory Affairs (M.S.), Neurology Business Group (H.H.), Japan and Asia Clinical Development, Eisai Co., Ltd., Bunkyo, Tokyo, Japan
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Kazuya Nagaoka
Neurology Business Group, Discovery (C.T.B.), Drug Metabolism and Pharmacokinetics (T.U.), hhc Data Creation Center (K.N.), and Medicine Development Center (T.A.), Eisai Co., Ltd., Tsukuba, Ibaraki, Japan; and Global Regulatory Affairs (M.S.), Neurology Business Group (H.H.), Japan and Asia Clinical Development, Eisai Co., Ltd., Bunkyo, Tokyo, Japan
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Tohru Arai
Neurology Business Group, Discovery (C.T.B.), Drug Metabolism and Pharmacokinetics (T.U.), hhc Data Creation Center (K.N.), and Medicine Development Center (T.A.), Eisai Co., Ltd., Tsukuba, Ibaraki, Japan; and Global Regulatory Affairs (M.S.), Neurology Business Group (H.H.), Japan and Asia Clinical Development, Eisai Co., Ltd., Bunkyo, Tokyo, Japan
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Hiroyuki Higashiyama
Neurology Business Group, Discovery (C.T.B.), Drug Metabolism and Pharmacokinetics (T.U.), hhc Data Creation Center (K.N.), and Medicine Development Center (T.A.), Eisai Co., Ltd., Tsukuba, Ibaraki, Japan; and Global Regulatory Affairs (M.S.), Neurology Business Group (H.H.), Japan and Asia Clinical Development, Eisai Co., Ltd., Bunkyo, Tokyo, Japan
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Journal of Pharmacology and Experimental Therapeutics: 362 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 362, Issue 2
1 Aug 2017
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Research ArticleDrug Discovery and Translational Medicine

In Vitro Characterization of DORA Lemborexant

Carsten Theodor Beuckmann, Michiyuki Suzuki, Takashi Ueno, Kazuya Nagaoka, Tohru Arai and Hiroyuki Higashiyama
Journal of Pharmacology and Experimental Therapeutics August 1, 2017, 362 (2) 287-295; DOI: https://doi.org/10.1124/jpet.117.241422

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Research ArticleDrug Discovery and Translational Medicine

In Vitro Characterization of DORA Lemborexant

Carsten Theodor Beuckmann, Michiyuki Suzuki, Takashi Ueno, Kazuya Nagaoka, Tohru Arai and Hiroyuki Higashiyama
Journal of Pharmacology and Experimental Therapeutics August 1, 2017, 362 (2) 287-295; DOI: https://doi.org/10.1124/jpet.117.241422
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