Journal of Pharmacology and Experimental Therapeutics: 362 (2)

August 01, 2017; Volume 362,Issue 2

Minireviews

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Pleiotropic and Adverse Effects of Statins—Do Epigenetics Play a Role?
Stephanie C. Allen and Cyril D.S. Mamotte

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 319-326; DOI: https://doi.org/10.1124/jpet.117.242081

Behavioral Pharmacology

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TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration
Michael Koblish, Richard Carr, Edward R. Siuda, David H. Rominger, William Gowen-MacDonald, Conrad L. Cowan, Aimee L. Crombie, Jonathan D. Violin and Michael W. Lark

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 254-262; DOI: https://doi.org/10.1124/jpet.117.241117
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Apparent Affinity Estimates and Reversal of the Effects of Synthetic Cannabinoids AM-2201, CP-47,497, JWH-122, and JWH-250 by Rimonabant in Rhesus Monkeys
Lenka Hruba and Lance R. McMahon

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 278-286; DOI: https://doi.org/10.1124/jpet.117.240572
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Cannabinoid CB₂ Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB₁ Mechanism that is Independent of CB₂ Receptors in Mice
Ai-Ling Li, Lawrence M. Carey, Ken Mackie and Andrea G. Hohmann

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 296-305; DOI: https://doi.org/10.1124/jpet.117.241901

Cardiovascular

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S1P receptor 1-Mediated Anti–Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2
Alice Marino, Takuya Sakamoto, Pablo A. Robador, Kengo Tomita and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 230-242; DOI: https://doi.org/10.1124/jpet.117.241976

Cellular and Molecular

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Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression
Inas Helwa, Vivek Choudhary, Xunsheng Chen, Ismail Kaddour-Djebbar and Wendy B. Bollag

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 243-253; DOI: https://doi.org/10.1124/jpet.116.239715

Chemotherapy, Antibiotics, and Gene Therapy

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Carboxyamidotriazole Synergizes with Sorafenib to Combat Non–Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis
Chen Chen, Rui Ju, Jing Shi, Wei Chen, Fangrui Sun, Lei Zhu, Juan Li, Dechang Zhang, Caiying Ye and Lei Guo

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 219-229; DOI: https://doi.org/10.1124/jpet.117.240986
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Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia
Andrea Henrich, Markus Joerger, Stefanie Kraff, Ulrich Jaehde, Wilhelm Huisinga, Charlotte Kloft and Zinnia Patricia Parra-Guillen

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 347-358; DOI: https://doi.org/10.1124/jpet.117.240309

Drug Discovery and Translational Medicine

Open Access
In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist
Carsten Theodor Beuckmann, Michiyuki Suzuki, Takashi Ueno, Kazuya Nagaoka, Tohru Arai and Hiroyuki Higashiyama

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 287-295; DOI: https://doi.org/10.1124/jpet.117.241422
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Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31
Lita A. Freeman, Stephen J. Demosky, Monika Konaklieva, Rostislav Kuskovsky, Angel Aponte, Alice F. Ossoli, Scott M. Gordon, Ross F. Koby, Kelly A. Manthei, Min Shen, Boris L. Vaisman, Robert D. Shamburek, Ajit Jadhav, Laura Calabresi, Marjan Gucek, John J.G. Tesmer, Rodney L. Levine and Alan T. Remaley

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 306-318; DOI: https://doi.org/10.1124/jpet.117.240457
Open Access
Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2
Jakob Busch-Petersen, Donald C. Carpenter, Miriam Burman, James Foley, Gerald E. Hunsberger, David J. Kilian, Michael Salmon, Ruth J. Mayer, John G. Yonchuk and Ruth Tal-Singer

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 338-346; DOI: https://doi.org/10.1124/jpet.117.240705
Open Access
Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development
Scott L. Harbeson, Adam J. Morgan, Julie F. Liu, Ara M. Aslanian, Sophia Nguyen, Gary W. Bridson, Christopher L. Brummel, Lijun Wu, Roger D. Tung, Lana Pilja, Virginia Braman and Vinita Uttamsingh

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 359-367; DOI: https://doi.org/10.1124/jpet.117.241497

Inflammation, Immunopharmacology, and Asthma

Open Access
Route of Administration Affects Corticosteroid Sensitivity of a Combined Ovalbumin and Lipopolysaccharide Model of Asthma Exacerbation in Guinea Pigs
Alexander P. P. Lowe, Rhian S. Thomas, Anthony T. Nials, Emma J. Kidd, Kenneth J. Broadley and William R. Ford

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 327-337; DOI: https://doi.org/10.1124/jpet.117.241927

Metabolism, Transport, and Pharmacogenomics

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Modeling Human Myocardium Exposure to Doxorubicin Defines the Risk of Heart Failure from Low-Dose Doxorubicin
Emanuela Salvatorelli, Pierantonio Menna, Massimo Chello, Elvio Covino and Giorgio Minotti

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 263-270; DOI: https://doi.org/10.1124/jpet.117.242388
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Potential Drug Interactions Mediated by Renal Organic Anion Transporter OATP4C1
Toshihiro Sato, Eikan Mishima, Nariyasu Mano, Takaaki Abe and Hiroaki Yamaguchi

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 271-277; DOI: https://doi.org/10.1124/jpet.117.241703

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

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