Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy

Torsten Hoffmann; Antje Meyer; Ulrich Heiser; Stephan Kurat; Livia Böhme; Martin Kleinschmidt; Karl-Ulrich Bühring; Birgit Hutter-Paier; Martina Farcher; Hans-Ulrich Demuth; Inge Lues; Stephan Schilling

doi:10.1124/jpet.117.240614

Research ArticleNeuropharmacology

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Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy

Torsten Hoffmann, Antje Meyer, Ulrich Heiser, Stephan Kurat, Livia Böhme, Martin Kleinschmidt, Karl-Ulrich Bühring, Birgit Hutter-Paier, Martina Farcher, Hans-Ulrich Demuth, Inge Lues and Stephan Schilling

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 119-130; DOI: https://doi.org/10.1124/jpet.117.240614

Torsten Hoffmann

Probiodrug AG, Halle, Germany (T.H., A.M., U.H., L.B., K.-U.B., I.L.); QPS Austria, Grambach, Austria (S.K., B.H.-P., M.F.); and Fraunhofer Institute for Cell Therapy and Immunology, Department for Drug Design and Target Validation, Halle, Germany (M.K., H.-U.D., S.S.)

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Antje Meyer

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Ulrich Heiser

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Stephan Kurat

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Livia Böhme

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Martin Kleinschmidt

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Karl-Ulrich Bühring

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Birgit Hutter-Paier

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Martina Farcher

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Hans-Ulrich Demuth

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Inge Lues

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Stephan Schilling

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Journal of Pharmacology and Experimental Therapeutics

Vol. 362, Issue 1

1 Jul 2017

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Research ArticleNeuropharmacology