Journal of Pharmacology and Experimental Therapeutics: 362 (1)

July 01, 2017; Volume 362,Issue 1

Behavioral Pharmacology

You have access
σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration
Takato Hiranita, Weimin C. Hong, Theresa Kopajtic and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 2-13; DOI: https://doi.org/10.1124/jpet.117.241109
You have access
Relief of Pain-Depressed Behavior in Rats by Activation of D1-Like Dopamine Receptors
Matthew F. Lazenka, Kelen C. Freitas, Sydney Henck and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 14-23; DOI: https://doi.org/10.1124/jpet.117.240796
You have access
Preference for an Opioid/Benzodiazepine Mixture over an Opioid Alone Using a Concurrent Choice Procedure in Rhesus Monkeys
Peter F. Weed, Charles P. France and Lisa R. Gerak

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 59-66; DOI: https://doi.org/10.1124/jpet.117.240200
You have access
Effects of Acute and Chronic Treatments with Dopamine D₂ and D₃ Receptor Ligands on Cocaine versus Food Choice in Rats
Morgane Thomsen, Andrew C. Barrett, Paul Butler, S. Stevens Negus and S. Barak Caine

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 161-176; DOI: https://doi.org/10.1124/jpet.117.241141
You have access
Apparent CB₁ Receptor Rimonabant Affinity Estimates: Combination with THC and Synthetic Cannabinoids in the Mouse In Vivo Triad Model
T. W. Grim, A. J. Morales, B. F. Thomas, J. L. Wiley, G. W. Endres, S. S. Negus and A. H. Lichtman

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 210-218; DOI: https://doi.org/10.1124/jpet.117.240192

Cardiovascular

You have access
Treatment with Standard and Low Dose of Conjugated Equine Estrogen Differentially Modulates Estrogen Receptor Expression and Response to Angiotensin II in Mesenteric Venular Bed of Surgically Postmenopausal Hypertensive Rats
Priscila Xavier Araujo, Tiago Januário Costa, Cinthya Echem, Maria Aparecida de Oliveira, Rosangela Aparecida Santos-Eichler, Lucas Giglio Colli, Francesc Jiménez-Altayó, Elisabet Vila, Eliana Hiromi Akamine, Ana Paula Dantas, Graziela Scalianti Ceravolo and Maria Helena Catelli de Carvalho

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 98-107; DOI: https://doi.org/10.1124/jpet.117.240465
Open Access
Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential
John Gatfield, Katalin Menyhart, Daniel Wanner, Carmela Gnerre, Lucile Monnier, Keith Morrison, Patrick Hess, Marc Iglarz, Martine Clozel and Oliver Nayler

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 186-199; DOI: https://doi.org/10.1124/jpet.116.239665

Cellular and Molecular

You have access
XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits
Derek L Greene, Seungwoo Kang and Naoto Hoshi

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 177-185; DOI: https://doi.org/10.1124/jpet.117.241679
You have access
Regulation of δ Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid–Dependent 12/15-Lipoxygenase Metabolites
Laura C. Sullivan, Teresa A. Chavera, Xiaoli Gao, Miryam M. Pando and Kelly A. Berg

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 200-209; DOI: https://doi.org/10.1124/jpet.117.241604

Drug Discovery and Translational Medicine

You have access
Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet–Induced Obese Rats
Thomas B. Estridge, Asim B. Dey, Charles Reidy, Xiaohong Yu, Yuke Zhang, Maryalice Hartley, Paul L. Milligan, Najia Jin, Mark C. Kowala, Jennifer K. Leohr, Adrian J. Fretland, Thomas E. Mabry, Debra Luffer-Atlas and M. Jane Luo

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 108-118; DOI: https://doi.org/10.1124/jpet.117.240242
You have access
Rational Tuning of Visual Cycle Modulator Pharmacodynamics
Philip D. Kiser, Jianye Zhang, Mohsen Badiee, Junzo Kinoshita, Neal S. Peachey, Gregory P. Tochtrop and Krzysztof Palczewski

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 131-145; DOI: https://doi.org/10.1124/jpet.117.240721

Endocrine and Diabetes

You have access
The Dual Amylin- and Calcitonin-Receptor Agonist KBP-042 Works as Adjunct to Metformin on Fasting Hyperglycemia and HbA1c in a Rat Model of Type 2 Diabetes
Sara T. Hjuler, Sofie Gydesen, Kim V. Andreassen, Morten A. Karsdal and Kim Henriksen

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 24-30; DOI: https://doi.org/10.1124/jpet.117.241281
You have access
LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice
David R. Powell, Melinda G. Smith, Deon D. Doree, Angela L. Harris, Jennifer Greer, Christopher M. DaCosta, Andrea Thompson, Sabrina Jeter-Jones, Wendy Xiong, Kenneth G. Carson, Nicole C. Goodwin, Bryce A. Harrison, David B. Rawlins, Eric D. Strobel, Suma Gopinathan, Alan Wilson, Faika Mseeh, Brian Zambrowicz and Zhi-Ming Ding

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 85-97; DOI: https://doi.org/10.1124/jpet.117.240820

Gastrointestinal, Hepatic, Pulmonary, and Renal

You have access
Glutamatergic Mechanisms Involved in Bladder Overactivity and Pudendal Neuromodulation in Cats
Jamie Uy, Michelle Yu, Xuewen Jiang, Cameron Jones, Bing Shen, Jicheng Wang, James R. Roppolo, William C. de Groat and Changfeng Tai

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 53-58; DOI: https://doi.org/10.1124/jpet.117.240895
Open Access
Mashiningan Improves Opioid-Induced Constipation in Rats by Activating Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
Yumi Harada, Seiichi Iizuka, Yayoi Saegusa, Sachiko Mogami, Naoki Fujitsuka and Tomohisa Hattori

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 78-84; DOI: https://doi.org/10.1124/jpet.117.240630

Neuropharmacology

Open Access
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman and Rudolph E. Tanzi

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 31-44; DOI: https://doi.org/10.1124/jpet.117.240861
You have access
Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone
Joanna C. Jacob, Justin L. Poklis, Hamid I. Akbarali, Graeme Henderson and William L. Dewey

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 45-52; DOI: https://doi.org/10.1124/jpet.117.241083
You have access
Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-κB Inhibition
Zheng-Qiang Zou, Jia-Jia Chen, Hong-Fang Feng, Yu-Fang Cheng, Hai-Tao Wang, Zhong-Zhen Zhou, Hai-Biao Guo, Wenhua Zheng and Jiang-Ping Xu

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 67-77; DOI: https://doi.org/10.1124/jpet.116.239608
Open Access
Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy
Torsten Hoffmann, Antje Meyer, Ulrich Heiser, Stephan Kurat, Livia Böhme, Martin Kleinschmidt, Karl-Ulrich Bühring, Birgit Hutter-Paier, Martina Farcher, Hans-Ulrich Demuth, Inge Lues and Stephan Schilling

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 119-130; DOI: https://doi.org/10.1124/jpet.117.240614
You have access
Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na_V1.7
Thomas J. Kornecook, Ruoyuan Yin, Stephen Altmann, Xuhai Be, Virginia Berry, Christopher P. Ilch, Michael Jarosh, Danielle Johnson, Josie H. Lee, Sonya G. Lehto, Joseph Ligutti, Dong Liu, Jason Luther, David Matson, Danny Ortuno, John Roberts, Kristin Taborn, Jinti Wang, Matthew M. Weiss, Violeta Yu, Dawn X. D. Zhu, Robert T. Fremeau and Bryan D. Moyer

Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 146-160; DOI: https://doi.org/10.1124/jpet.116.239590

Erratum

You have access
Correction to “Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine”
Journal of Pharmacology and Experimental Therapeutics July 2017, 362 (1) 1; DOI: https://doi.org/10.1124/jpet.116.239228err

Main menu

User menu

Search

Table of Contents

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Neuropharmacology

Erratum

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals