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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2017; Volume 361,Issue 2

Cardiovascular

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    Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference
    Christoph Koepple, Daniel Scherer, Claudia Seyler, Eberhard Scholz, Dierk Thomas, Hugo A. Katus and Edgar Zitron
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 209-218; DOI: https://doi.org/10.1124/jpet.116.238287
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    Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention
    Magali Vercauteren, Frederic Trensz, Anne Pasquali, Christophe Cattaneo, Daniel S. Strasser, Patrick Hess, Marc Iglarz and Martine Clozel
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 322-333; DOI: https://doi.org/10.1124/jpet.116.234930
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    Low-Volume Resuscitation for Hemorrhagic Shock: Understanding the Mechanism of PEG-20k
    Valerie Plant, Dan W. Parrish, Ashley Limkemann, Paula Ferrada, Michel Aboutanos and Martin J. Mangino
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 334-340; DOI: https://doi.org/10.1124/jpet.116.239822

Cellular and Molecular

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    Label-Free Dynamic Mass Redistribution Reveals Low-Density, Prosurvival α1B-Adrenergic Receptors in Human SW480 Colon Carcinoma Cells
    Dorathy-Ann Harris, Ji-Min Park, Kyung-Soon Lee, Cong Xu, Nephi Stella and Chris Hague
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 219-228; DOI: https://doi.org/10.1124/jpet.116.237255

Chemotherapy, Antibiotics, and Gene Therapy

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    Functional, Metabolic, and Dynamic Mitochondrial Changes in the Rat Cirrhosis-Hepatocellular Carcinoma Model and the Protective Effect of IFC-305
    Enrique Chávez, María Guadalupe Lozano-Rosas, Mariana Domínguez-López, Gabriela Velasco-Loyden, Jesús Rafael Rodríguez-Aguilera, Concepción José-Nuñez, Marietta Tuena de Gómez-Puyou and Victoria Chagoya de Sánchez
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 292-302; DOI: https://doi.org/10.1124/jpet.116.239301

Drug Discovery and Translational Medicine

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    Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy
    Christopher T. Salatto, Russell A. Miller, Kimberly O. Cameron, Emily Cokorinos, Allan Reyes, Jessica Ward, Matthew F. Calabrese, Ravi G. Kurumbail, Francis Rajamohan, Amit S. Kalgutkar, David A. Tess, Andre Shavnya, Nathan E. Genung, David J. Edmonds, Aditi Jatkar, Benjamin S Maciejewski, Marina Amaro, Harmeet Gandhok, Mara Monetti, Katherine Cialdea, Eliza Bollinger, John M. Kreeger, Timothy M. Coskran, Alan C. Opsahl, Germaine G. Boucher, Morris J. Birnbaum, Paul DaSilva-Jardine and Tim Rolph
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 303-311; DOI: https://doi.org/10.1124/jpet.116.237925
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    Dual Inhibition of Bruton’s Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin’s B Cell Malignancies
    Jennifer Alfaro, Felipe Pérez de Arce, Sebastián Belmar, Glenda Fuentealba, Patricio Avila, Gonzalo Ureta, Camila Flores, Claudia Acuña, Luz Delgado, Diana Gaete, Brahmam Pujala, Anup Barde, Anjan K. Nayak, T. V. R. Upendra, Dhananjay Patel, Shailender Chauhan, Vijay K. Sharma, Stacy Kanno, Ramona G. Almirez, David T. Hung, Sarvajit Chakravarty, Roopa Rai, Sebastián Bernales, Kevin P. Quinn, Son M. Pham and Emma McCullagh
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 312-321; DOI: https://doi.org/10.1124/jpet.116.238022

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways
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    Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways
    Lijun Tao, Jinyu Yang, Fengyan Cao, Haifeng Xie, Mian Zhang, Yanqing Gong and Chaofeng Zhang
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 268-279; DOI: https://doi.org/10.1124/jpet.116.239137
  • Open Access
    Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation
    Eike Floettmann, Khanh Bui, Mark Sostek, Kemal Payza and Michael Eldon
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 280-291; DOI: https://doi.org/10.1124/jpet.116.239061

Inflammation, Immunopharmacology, and Asthma

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    Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor
    Fiona Elwood, David J. Witter, Jennifer Piesvaux, Brian Kraybill, Nathan Bays, Carla Alpert, Peter Goldenblatt, Yujie Qu, Irena Ivanovska, Hyun-Hee Lee, Chi-Sung Chiu, Hao Tang, Mark E. Scott, Sujal V. Deshmukh, Mark Zielstorff, Alan Byford, Kalyan Chakravarthy, Lauren Dorosh, Alexey Rivkin, Joel Klappenbach, Bo-Sheng Pan, Ilona Kariv, Christopher Dinsmore, Deborah Slipetz and Peter J. Dandliker
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 229-244; DOI: https://doi.org/10.1124/jpet.116.239723

Metabolism, Transport, and Pharmacogenomics

  • Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation
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    Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation
    Ayumi Kurita, Yuu Miyauchi, Shin’ichi Ikushiro, Peter I. Mackenzie, Hideyuki Yamada and Yuji Ishii
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 199-208; DOI: https://doi.org/10.1124/jpet.117.240382
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    Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions
    Jing Jing, Cara Nelson, Jisun Paik, Yoshiyuki Shirasaka, John K. Amory and Nina Isoherranen
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 246-258; DOI: https://doi.org/10.1124/jpet.117.240523

Toxicology

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    Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing
    Joseph W. Zagorski, Tyler P. Maser, Karen T. Liby and Cheryl E. Rockwell
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 259-267; DOI: https://doi.org/10.1124/jpet.116.238899

Erratum

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    Correction to: “Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences.”
    Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 245; DOI: https://doi.org/10.1124/jpet.116.238717err
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Journal of Pharmacology and Experimental Therapeutics: 361 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 361, Issue 2
1 May 2017
  • Table of Contents
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  • Cardiovascular
  • Cellular and Molecular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Toxicology
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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