Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Daniel Scotcher; Christopher R. Jones; Aleksandra Galetin; Amin Rostami-Hodjegan

doi:10.1124/jpet.116.237438

Research ArticleMetabolism, Transport, and Pharmacogenomics

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Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Daniel Scotcher, Christopher R. Jones, Aleksandra Galetin and Amin Rostami-Hodjegan

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 484-495; DOI: https://doi.org/10.1124/jpet.116.237438

Daniel Scotcher

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, United Kingdom (D.S., A.G., A.R.-H.); DMPK, Oncology iMed, AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, United Kingdom (C.R.J.); and Simcyp Limited (a Certara Company), Blades Enterprise Centre, Sheffield, United Kingdom (A.R.-H.)

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Christopher R. Jones

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Aleksandra Galetin

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Amin Rostami-Hodjegan

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Journal of Pharmacology and Experimental Therapeutics

Vol. 360, Issue 3

1 Mar 2017

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Research ArticleMetabolism, Transport, and Pharmacogenomics