Journal of Pharmacology and Experimental Therapeutics: 360 (3)

March 01, 2017; Volume 360,Issue 3

Cardiovascular

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Regulator of G Protein Signaling 6 Protects the Heart from Ischemic Injury
Boyd R. Rorabaugh, Bandana Chakravarti, Nathaniel W. Mabe, Sarah L. Seeley, Albert D. Bui, Jianqi Yang, Stephanie W. Watts, Richard R. Neubig and Rory A. Fisher

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 409-416; DOI: https://doi.org/10.1124/jpet.116.238345
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Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D₂ Receptor Subtype 1
Deping Kong, Juanjuan Li, Yujun Shen, Guizhu Liu, Shengkai Zuo, Bo Tao, Yong Ji, Ankang Lu, Michael Lazarus, Richard M. Breyer and Ying Yu

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 435-444; DOI: https://doi.org/10.1124/jpet.116.238261
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Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals
Christopher M. Barbieri, Xinkang Wang, Weizhen Wu, Xueping Zhou, Aimie M. Ogawa, Kim O’Neill, Donald Chu, Gino Castriota, Dietmar A. Seiffert, David E. Gutstein and Zhu Chen

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 466-475; DOI: https://doi.org/10.1124/jpet.116.238493
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Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits
Xinkang Wang, Stan Kurowski, Weizhen Wu, Gino A. Castriota, Xueping Zhou, Lin Chu, Kenneth P. Ellsworth, Donald Chu, Scott Edmondson, Amjad Ali, Patrick Andre, Dietmar Seiffert, Mark Erion, David E. Gutstein and Zhu Chen

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 476-483; DOI: https://doi.org/10.1124/jpet.116.238600

Cellular and Molecular

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Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4)
William G. Robichaux, Melissa Branham-O’Connor, Il-Young Hwang, Ali Vural, Johne H. Kehrl and Joe B. Blumer

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 424-433; DOI: https://doi.org/10.1124/jpet.116.238436

Drug Discovery and Translational Medicine

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Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model
Maria Garcia-Cremades, Celine Pitou, Philip W. Iversen and Iñaki F. Troconiz

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 445-456; DOI: https://doi.org/10.1124/jpet.116.237610

Metabolism, Transport, and Pharmacogenomics

Open Access
Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations
Daniel Scotcher, Christopher R. Jones, Aleksandra Galetin and Amin Rostami-Hodjegan

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 484-495; DOI: https://doi.org/10.1124/jpet.116.237438

Neuropharmacology

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Inhibition of Leukotriene B₄ Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice
Masanori Hijioka, Junpei Anan, Hayato Ishibashi, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki, Tomoaki Koga, Takehiko Yokomizo, Takao Shimizu and Hiroshi Katsuki

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 399-408; DOI: https://doi.org/10.1124/jpet.116.238824
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Dissecting the Influence of Two Structural Substituents on the Differential Neurotoxic Effects of Acute Methamphetamine and Mephedrone Treatment on Dopamine Nerve Endings with the Use of 4-Methylmethamphetamine and Methcathinone
John H. Anneken, Mariana Angoa-Pérez, Girish C. Sati, David Crich and Donald M. Kuhn

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 417-423; DOI: https://doi.org/10.1124/jpet.116.237768
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Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography
Katsukuni Mitsui, Noriko Morimoto, Tomohiro Niwa, Yoshiyuki Yamaura, Hiroyuki Ohba, Hideo Tsukada and Seishi Katsumata

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 457-465; DOI: https://doi.org/10.1124/jpet.116.238568

Toxicology

Open Access
Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin
Anyamanee Chaiprasongsuk, Jinaphat Lohakul, Kitipong Soontrapa, Somponnat Sampattavanich, Pravit Akarasereenont and Uraiwan Panich

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 388-398; DOI: https://doi.org/10.1124/jpet.116.238048

Letters to the Editor

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Rosuvastatin and Its Evolving Role as a Vascular Remodeling and Antiproliferative Agent in Different Systemic Malignancies
Shailendra Kapoor

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 434; DOI: https://doi.org/10.1124/jpet.116.239400

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Table of Contents

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Letters to the Editor

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