Journal of Pharmacology and Experimental Therapeutics: 360 (2)

February 01, 2017; Volume 360,Issue 2

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Idiosyncratic Drug-Induced Liver Injury: Is Drug-Cytokine Interaction the Linchpin?
Robert A. Roth, Ashley R. Maiuri and Patricia E. Ganey

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 368-377; DOI: https://doi.org/10.1124/jpet.116.237578

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Behavioral Characterization of κ Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats
Vanessa Minervini, Sujata Dahal and Charles P. France

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 280-287; DOI: https://doi.org/10.1124/jpet.116.235630

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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach
Nelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Dean F. Rigel, Randy L. Webb, David Feldman, Fumin Fu, Michael Beil, Liang Jin, Donald R. Stanski and Meindert Danhof

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 356-367; DOI: https://doi.org/10.1124/jpet.116.236208

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Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor
Wiebke K. Seemann, Daniela Wenzel, Ramona Schrage, Justine Etscheid, Theresa Bödefeld, Anna Bartol, Mareille Warnken, Philipp Sasse, Jessica Klöckner, Ulrike Holzgrabe, Marco DeAmici, Eberhard Schlicker, Kurt Racké, Evi Kostenis, Rainer Meyer, Bernd K. Fleischmann and Klaus Mohr

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 289-299; DOI: https://doi.org/10.1124/jpet.116.237149
Open Access
Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
Terry Petrou, Hervør L. Olsen, Christopher Thrasivoulou, John R. Masters, Jonathan F. Ashmore and Aamir Ahmed

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 378-387; DOI: https://doi.org/10.1124/jpet.116.236695

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Reveglucosidase alfa (BMN 701), an IGF2-Tagged rhAcid α-Glucosidase, Improves Respiratory Functional Parameters in a Murine Model of Pompe Disease
Jeffrey Peng, Jill Dalton, Mark Butt, Kristin Tracy, Derek Kennedy, Peter Haroldsen, Rhea Cahayag, Stephen Zoog, Charles A. O’Neill and Laurie S. Tsuruda

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 313-323; DOI: https://doi.org/10.1124/jpet.116.235952
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Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder
J. Di Salvo, H. Nagabukuro, L. A. Wickham, C. Abbadie, J. A. DeMartino, A. Fitzmaurice, L. Gichuru, A. Kulick, M. J. Donnelly, N. Jochnowitz, A. L. Hurley, A. Pereira, A. Sanfiz, G. Veronin, K. Villa, J. Woods, B. Zamlynny, E. Zycband, G.M. Salituro, T. Frenkl, A. E. Weber, S. D. Edmondson and M. Struthers

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 346-355; DOI: https://doi.org/10.1124/jpet.116.237313

Open Access
Effects of Antihypertensive Agents on Intestinal Contractility in the Spontaneously Hypertensive Rat: Angiotensin Receptor System Downregulation by Losartan
Glen Stephen Patten and Mahinda Yapa Abeywardena

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 260-266; DOI: https://doi.org/10.1124/jpet.116.237586
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Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension
Robert J. Aiello, Patricia-Ann Bourassa, Qing Zhang, Jeffrey Dubins, Daniel R. Goldberg, Stéphane De Lombaert, Marc Humbert, Christophe Guignabert, Maria A. Cavasin, Timothy A. McKinsey and Vishwas Paralkar

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 267-279; DOI: https://doi.org/10.1124/jpet.116.237933

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Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways
Soumita De, Alak Manna, Sunanda Kundu, Sritama De Sarkar, Uttara Chatterjee, Tuhinadri Sen, Subrata Chattopadhyay and Mitali Chatterjee

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 249-259; DOI: https://doi.org/10.1124/jpet.116.238444
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GS-5759, a Bifunctional β₂-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells
Taruna Joshi, Dong Yan, Omar Hamed, Stacey L. Tannheimer, Gary B. Phillips, Clifford D. Wright, Musong Kim, Michael Salmon, Robert Newton and Mark A. Giembycz

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 324-340; DOI: https://doi.org/10.1124/jpet.116.237743

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Two Janus Cannabinoids That Are Both CB₂ Agonists and CB₁ Antagonists
Amey Dhopeshwarkar, Natalia Murataeva, Alex Makriyannis, Alex Straiker and Ken Mackie

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 300-311; DOI: https://doi.org/10.1124/jpet.116.236539

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The Glutamate Model of Schizophrenia: It’s All About Signal Muscarinic Connections
Costa Vakalopoulos

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 288; DOI: https://doi.org/10.1124/jpet.116.238766
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Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1
Hong Shen, Wenying Li, W. Griffith Humphreys and Yurong Lai

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 341-342; DOI: https://doi.org/10.1124/jpet.116.238337

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Response to “Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1”
Gerard Minuesa, Christopher Albert, Marçal Pastor-Anglada, Javier Martinez-Picado and Hermann Koepsell

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 343-345; DOI: https://doi.org/10.1124/jpet.116.239004

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Correction to: “Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.”
Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 312; DOI: https://doi.org/10.1124/jpet.115.225375err