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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2017; Volume 360,Issue 2

Minireview

  • You have access
    Idiosyncratic Drug-Induced Liver Injury: Is Drug-Cytokine Interaction the Linchpin?
    Robert A. Roth, Ashley R. Maiuri and Patricia E. Ganey
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 368-377; DOI: https://doi.org/10.1124/jpet.116.237578

Behavioral Pharmacology

  • You have access
    Behavioral Characterization of κ Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats
    Vanessa Minervini, Sujata Dahal and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 280-287; DOI: https://doi.org/10.1124/jpet.116.235630

Cardiovascular

  • Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach
    You have access
    Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach
    Nelleke Snelder, Bart A. Ploeger, Olivier Luttringer, Dean F. Rigel, Randy L. Webb, David Feldman, Fumin Fu, Michael Beil, Liang Jin, Donald R. Stanski and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 356-367; DOI: https://doi.org/10.1124/jpet.116.236208

Cellular and Molecular

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    Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor
    Wiebke K. Seemann, Daniela Wenzel, Ramona Schrage, Justine Etscheid, Theresa Bödefeld, Anna Bartol, Mareille Warnken, Philipp Sasse, Jessica Klöckner, Ulrike Holzgrabe, Marco DeAmici, Eberhard Schlicker, Kurt Racké, Evi Kostenis, Rainer Meyer, Bernd K. Fleischmann and Klaus Mohr
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 289-299; DOI: https://doi.org/10.1124/jpet.116.237149
  • Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
    Open Access
    Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
    Terry Petrou, Hervør L. Olsen, Christopher Thrasivoulou, John R. Masters, Jonathan F. Ashmore and Aamir Ahmed
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 378-387; DOI: https://doi.org/10.1124/jpet.116.236695

Drug Discovery and Translational Medicine

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    Reveglucosidase alfa (BMN 701), an IGF2-Tagged rhAcid α-Glucosidase, Improves Respiratory Functional Parameters in a Murine Model of Pompe Disease
    Jeffrey Peng, Jill Dalton, Mark Butt, Kristin Tracy, Derek Kennedy, Peter Haroldsen, Rhea Cahayag, Stephen Zoog, Charles A. O’Neill and Laurie S. Tsuruda
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 313-323; DOI: https://doi.org/10.1124/jpet.116.235952
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    Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder
    J. Di Salvo, H. Nagabukuro, L. A. Wickham, C. Abbadie, J. A. DeMartino, A. Fitzmaurice, L. Gichuru, A. Kulick, M. J. Donnelly, N. Jochnowitz, A. L. Hurley, A. Pereira, A. Sanfiz, G. Veronin, K. Villa, J. Woods, B. Zamlynny, E. Zycband, G.M. Salituro, T. Frenkl, A. E. Weber, S. D. Edmondson and M. Struthers
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 346-355; DOI: https://doi.org/10.1124/jpet.116.237313

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Open Access
    Effects of Antihypertensive Agents on Intestinal Contractility in the Spontaneously Hypertensive Rat: Angiotensin Receptor System Downregulation by Losartan
    Glen Stephen Patten and Mahinda Yapa Abeywardena
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 260-266; DOI: https://doi.org/10.1124/jpet.116.237586
  • You have access
    Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension
    Robert J. Aiello, Patricia-Ann Bourassa, Qing Zhang, Jeffrey Dubins, Daniel R. Goldberg, Stéphane De Lombaert, Marc Humbert, Christophe Guignabert, Maria A. Cavasin, Timothy A. McKinsey and Vishwas Paralkar
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 267-279; DOI: https://doi.org/10.1124/jpet.116.237933

Inflammation, Immunopharmacology, and Asthma

  • Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways
    You have access
    Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways
    Soumita De, Alak Manna, Sunanda Kundu, Sritama De Sarkar, Uttara Chatterjee, Tuhinadri Sen, Subrata Chattopadhyay and Mitali Chatterjee
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 249-259; DOI: https://doi.org/10.1124/jpet.116.238444
  • You have access
    GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells
    Taruna Joshi, Dong Yan, Omar Hamed, Stacey L. Tannheimer, Gary B. Phillips, Clifford D. Wright, Musong Kim, Michael Salmon, Robert Newton and Mark A. Giembycz
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 324-340; DOI: https://doi.org/10.1124/jpet.116.237743

Neuropharmacology

  • You have access
    Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists
    Amey Dhopeshwarkar, Natalia Murataeva, Alex Makriyannis, Alex Straiker and Ken Mackie
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 300-311; DOI: https://doi.org/10.1124/jpet.116.236539

Letters to the Editor

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    The Glutamate Model of Schizophrenia: It’s All About Signal Muscarinic Connections
    Costa Vakalopoulos
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 288; DOI: https://doi.org/10.1124/jpet.116.238766
  • You have access
    Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1
    Hong Shen, Wenying Li, W. Griffith Humphreys and Yurong Lai
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 341-342; DOI: https://doi.org/10.1124/jpet.116.238337

Response Letters

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    Response to “Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1”
    Gerard Minuesa, Christopher Albert, Marçal Pastor-Anglada, Javier Martinez-Picado and Hermann Koepsell
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 343-345; DOI: https://doi.org/10.1124/jpet.116.239004

Erratum

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    Correction to: “Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.”
    Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 312; DOI: https://doi.org/10.1124/jpet.115.225375err
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Journal of Pharmacology and Experimental Therapeutics: 360 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 360, Issue 2
1 Feb 2017
  • Table of Contents
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