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Research ArticleChemotherapy, Antibiotics, and Gene Therapy

Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform

Ragu Kanagasabai, Lucas Serdar, Soumendrakrishna Karmahapatra, Corey A. Kientz, Justin Ellis, Mary K. Ritke, Terry S. Elton and Jack C. Yalowich
Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 152-163; DOI: https://doi.org/10.1124/jpet.116.237107
Ragu Kanagasabai
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Lucas Serdar
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Soumendrakrishna Karmahapatra
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Corey A. Kientz
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Justin Ellis
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Mary K. Ritke
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Terry S. Elton
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Jack C. Yalowich
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
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Article Information

vol. 360 no. 1 152-163
DOI 
https://doi.org/10.1124/jpet.116.237107
PubMed 
27974648

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 9, 2016
  • Accepted November 4, 2016
  • Published online December 14, 2016.

Article Versions

  • Earlier version (November 10, 2016 - 07:41).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ragu Kanagasabai,
  2. Lucas Serdar,
  3. Soumendrakrishna Karmahapatra,
  4. Corey A. Kientz,
  5. Justin Ellis,
  6. Mary K. Ritke,
  7. Terry S. Elton, and
  8. Jack C. Yalowich
  1. Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio (R.K., L.S., S.K., C.A.K., J.E., T.S.E., J.C.Y.); James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (J.C.Y.); and Department of Biology, University of Indianapolis, Indianapolis, Indiana (M.K.R.)
  1. Address correspondence to:
    Dr. Jack C. Yalowich, Division of Pharmacology, College of Pharmacy, Ohio State University, 500 West 12th Avenue, Columbus, OH 43210. E-mail: yalowich.1{at}osu.edu or Dr. Terry S. Elton, Division of Pharmacology, College of Pharmacy, Ohio State University, 500 West 12th Avenue, Columbus, OH 43210. E-mail: elton.8{at}osu.edu
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Journal of Pharmacology and Experimental Therapeutics: 360 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 360, Issue 1
1 Jan 2017
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Research ArticleChemotherapy, Antibiotics, and Gene Therapy

Intron Retention Results in a Novel TOP2α/90-kDa Isoform

Ragu Kanagasabai, Lucas Serdar, Soumendrakrishna Karmahapatra, Corey A. Kientz, Justin Ellis, Mary K. Ritke, Terry S. Elton and Jack C. Yalowich
Journal of Pharmacology and Experimental Therapeutics January 1, 2017, 360 (1) 152-163; DOI: https://doi.org/10.1124/jpet.116.237107

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Research ArticleChemotherapy, Antibiotics, and Gene Therapy

Intron Retention Results in a Novel TOP2α/90-kDa Isoform

Ragu Kanagasabai, Lucas Serdar, Soumendrakrishna Karmahapatra, Corey A. Kientz, Justin Ellis, Mary K. Ritke, Terry S. Elton and Jack C. Yalowich
Journal of Pharmacology and Experimental Therapeutics January 1, 2017, 360 (1) 152-163; DOI: https://doi.org/10.1124/jpet.116.237107
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