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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2017; Volume 360,Issue 1

Minireviews

  • You have access
    Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders
    Amanda Crider and Anilkumar Pillai
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 48-58; DOI: https://doi.org/10.1124/jpet.116.237412
  • You have access
    Oxidative Stress and the Central Nervous System
    Samina Salim
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 201-205; DOI: https://doi.org/10.1124/jpet.116.237503

Cardiovascular

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    Xanthohumol Modulates Calcium Signaling in Rat Ventricular Myocytes: Possible Antiarrhythmic Properties
    Juan Jose Arnaiz-Cot, Lars Cleemann and Martin Morad
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 239-248; DOI: https://doi.org/10.1124/jpet.116.236588

Cellular and Molecular

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    Mutation-Induced Functional Alterations of CCR6
    Bina Julian, Kevin Gao, Benjamin N. Harwood, Martin Beinborn and Alan S. Kopin
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 106-116; DOI: https://doi.org/10.1124/jpet.116.237669

Chemotherapy, Antibiotics, and Gene Therapy

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    Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform
    Ragu Kanagasabai, Lucas Serdar, Soumendrakrishna Karmahapatra, Corey A. Kientz, Justin Ellis, Mary K. Ritke, Terry S. Elton and Jack C. Yalowich
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 152-163; DOI: https://doi.org/10.1124/jpet.116.237107
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    Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture
    Liting Deng, Lindsay Ng, Tatsuya Ozawa and Nephi Stella
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 215-224; DOI: https://doi.org/10.1124/jpet.116.236968

Drug Discovery and Translational Medicine

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    Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
    Gretchen Bain, Kristen E. Shannon, Fei Huang, Janice Darlington, Lance Goulet, Patricia Prodanovich, Gina L. Ma, Angelina M. Santini, Adam J. Stein, Dave Lonergan, Christopher D. King, Imelda Calderon, Andiliy Lai, John H. Hutchinson and Jilly F. Evans
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 1-13; DOI: https://doi.org/10.1124/jpet.116.237156
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    An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice
    Anh Do, Robert C. Reid, Rink-Jan Lohman, Matthew J. Sweet, David P. Fairlie and Abishek Iyer
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 140-151; DOI: https://doi.org/10.1124/jpet.116.236711

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett’s Associated Esophageal Adenocarcinoma Cells
    Dan Li, Jie Hong and Weibiao Cao
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 14-22; DOI: https://doi.org/10.1124/jpet.116.236620
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    Urinary Excretion Contributes to Long-Lasting Blockade of Bladder Muscarinic Receptors by Imidafenacin: Effect of Bilateral Ureteral Ligation
    Yoshihiko Ito, Shiori Kuraoka, Soma Endo, Ayaka Takahashi, Satomi Onoue and Shizuo Yamada
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 69-74; DOI: https://doi.org/10.1124/jpet.116.236497
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    Disrupted Murine Gut–to–Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models
    Edwin C. Y. Chow, Holly P. Quach, Yueping Zhang, Jason Z. Y. Wang, David C. Evans, Albert P. Li, Jose Silva, Rommel G. Tirona, Yurong Lai and K. Sandy Pang
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 174-191; DOI: https://doi.org/10.1124/jpet.116.236935

Inflammation, Immunopharmacology, and Asthma

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    NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid–Induced Murine Colitis
    Haruka Yokota, Ayaka Tsuzuki, Yuki Shimada, Azusa Imai, Daichi Utsumi, Takuya Tsukahara, Misaki Matsumoto, Kikuko Amagase, Kazumi Iwata, Akio Nakamura, Chihiro Yabe-Nishimura and Shinichi Kato
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 192-200; DOI: https://doi.org/10.1124/jpet.116.235580

Metabolism, Transport, and Pharmacogenomics

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    Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase
    Junji Furukawa, Katsuhisa Inoue, Kinya Ohta, Tomoya Yasujima, Yoshihisa Mimura and Hiroaki Yuasa
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 59-68; DOI: https://doi.org/10.1124/jpet.116.236984
  • Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
    Open Access
    Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
    N. Tsamandouras, T. Kostrzewski, C. L. Stokes, L. G. Griffith, D. J. Hughes and M. Cirit
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 95-105; DOI: https://doi.org/10.1124/jpet.116.237495
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    Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors
    Julie-Anne Tanner, Bhagwat Prasad, Katrina G. Claw, Patricia Stapleton, Amarjit Chaudhry, Erin G. Schuetz, Kenneth E. Thummel and Rachel F. Tyndale
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 129-139; DOI: https://doi.org/10.1124/jpet.116.237594
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    Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non–Michaelis-Menten P450 Kinetics on Fraction Metabolized
    Stephen Fowler, Elena Guerini, NaHong Qiu, Yumi Cleary, Neil Parrott, Gerard Greig and Navita L. Mallalieu
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 164-173; DOI: https://doi.org/10.1124/jpet.116.237214
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    Hormonal and Chemical Regulation of the Glut9 Transporter in Mice
    Pengli Bu, Yuan Le, Yue Zhang and Xingguo Cheng
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 206-214; DOI: https://doi.org/10.1124/jpet.116.237040

Neuropharmacology

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    The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala
    Steven L. Miller, Vassiliki Aroniadou-Anderjaska, Volodymyr I. Pidoplichko, Taiza H. Figueiredo, James P. Apland, Jishnu K. S. Krishnan and Maria F. M. Braga
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 23-32; DOI: https://doi.org/10.1124/jpet.116.236125
  • You have access
    Structure-Activity Relationships of Substituted Cathinones, with Transporter Binding, Uptake, and Release
    Amy J. Eshleman, Katherine M. Wolfrum, John F. Reed, Sunyoung O. Kim, Tracy Swanson, Robert A. Johnson and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 33-47; DOI: https://doi.org/10.1124/jpet.116.236349
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    TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington’s Disease
    Akina Harada, Kazunori Suzuki and Haruhide Kimura
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 75-83; DOI: https://doi.org/10.1124/jpet.116.237388
  • Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice
    You have access
    Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice
    Nathan C. Mitchell, Melodi A. Bowman, Georgianna G. Gould, Wouter Koek and Lynette C. Daws
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 84-94; DOI: https://doi.org/10.1124/jpet.116.237305
  • Open Access
    An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
    Kjell A. Svensson, Beverly A. Heinz, John M. Schaus, James P. Beck, Junliang Hao, Joseph H. Krushinski, Matthew R. Reinhard, Michael P. Cohen, Sarah L. Hellman, Brian G. Getman, Xushan Wang, Michelle M. Menezes, Deanna L. Maren, Julie F. Falcone, Wesley H. Anderson, Rebecca A. Wright, S. Michelle Morin, Kelly L. Knopp, Benjamin L. Adams, Borys Rogovoy, Ilya Okun, Todd M. Suter, Michael A. Statnick, Donald R. Gehlert, David L. Nelson, Virginia L. Lucaites, Renee Emkey, Neil W. DeLapp, Todd R. Wiernicki, Jeffrey W. Cramer, Charles R. Yang and Robert F. Bruns
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 117-128; DOI: https://doi.org/10.1124/jpet.116.236372

Toxicology

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    Bruton’s Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats
    Rebecca I. Erickson, Leah K. Schutt, Jacqueline M. Tarrant, Michelle McDowell, Lichuan Liu, Adam R. Johnson, Sock-Cheng Lewin-Koh, Maj Hedehus, Jed Ross, Richard A. D. Carano, Karin Staflin, Fiona Zhong, James J. Crawford, Shelly Zhong, Karin Reif, Arna Katewa, Harvey Wong, Wendy B. Young, Donna M. Dambach and Dinah L. Misner
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 226-238; DOI: https://doi.org/10.1124/jpet.116.236224

Erratum

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    Correction to: “A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer
    Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 225; DOI: https://doi.org/10.1124/jpet.113.220335err
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Journal of Pharmacology and Experimental Therapeutics: 360 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 360, Issue 1
1 Jan 2017
  • Table of Contents
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  • Minireviews
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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