Journal of Pharmacology and Experimental Therapeutics: 359 (3)

December 01, 2016; Volume 359,Issue 3

Behavioral Pharmacology

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Effects of Lorcaserin on Cocaine and Methamphetamine Self-Administration and Reinstatement of Responding Previously Maintained by Cocaine in Rhesus Monkeys
Lisa R. Gerak, Gregory T. Collins and Charles P. France

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 383-391; DOI: https://doi.org/10.1124/jpet.116.236307
Open Access
Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist
N. Levy-Cooperman, G. McIntyre, L. Bonifacio, M. McDonnell, J. M. Davenport, P. S. Covington, L. S. Dove and E. M. Sellers

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 471-481; DOI: https://doi.org/10.1124/jpet.116.236547

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Constitutive Desensitization of Opioid Receptors in Peripheral Sensory Neurons
Laura C. Sullivan, Teresa S. Chavera, Raehannah J. Jamshidi, Kelly A. Berg and William P. Clarke

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 411-419; DOI: https://doi.org/10.1124/jpet.116.232835

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Akebia Saponin D Decreases Hepatic Steatosis through Autophagy Modulation
Li-li Gong, Guang-run Li, Wen Zhang, He Liu, Ya-li Lv, Fei-fei Han, Zi-rui Wan, Ming-biao Shi and Li-hong Liu

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 392-400; DOI: https://doi.org/10.1124/jpet.116.236562

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8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity
Edwin K. Jackson, Delbert G. Gillespie and Zaichuan Mi

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 420-435; DOI: https://doi.org/10.1124/jpet.116.237552
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Contribution of GABA_A, Glycine, and Opioid Receptors to Sacral Neuromodulation of Bladder Overactivity in Cats
Xuewen Jiang, Thomas W. Fuller, Jathin Bandari, Utsav Bansal, Zhaocun Zhang, Bing Shen, Jicheng Wang, James R. Roppolo, William C. de Groat and Changfeng Tai

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 436-441; DOI: https://doi.org/10.1124/jpet.116.235846
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Potential L-Type Voltage–Operated Calcium Channel Blocking Effect of Drotaverine on Functional Models
Zoltán Patai, András Guttman and Endre G. Mikus

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 442-451; DOI: https://doi.org/10.1124/jpet.116.237271

Open Access
Exploration of α1-Antitrypsin Treatment Protocol for Islet Transplantation: Dosing Plan and Route of Administration
Boris M. Baranovski, Eyal Ozeri, Galit Shahaf, David E. Ochayon, Ronen Schuster, Nofar Bahar, Noa Kalay, Pablo Cal, Mark I. Mizrahi, Omer Nisim, Pnina Strauss, Eran Schenker and Eli C. Lewis

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 482-490; DOI: https://doi.org/10.1124/jpet.116.236067

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Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation
Jia Yin, Haichuan Duan and Joanne Wang

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 401-410; DOI: https://doi.org/10.1124/jpet.116.236158
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Blood–Brain Barrier Disruption and Neurovascular Unit Dysfunction in Diabetic Mice: Protection with the Mitochondrial Carbonic Anhydrase Inhibitor Topiramate
Therese S. Salameh, Gul N. Shah, Tulin O. Price, Melvin R. Hayden and William A. Banks

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 452-459; DOI: https://doi.org/10.1124/jpet.116.237057

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Modafinil Activates Phasic Dopamine Signaling in Dorsal and Ventral Striata
Martin J. Bobak, Matthew W. Weber, Melissa A. Doellman, Douglas R. Schuweiler, Jeana M. Athens, Steven A. Juliano and Paul A. Garris

Journal of Pharmacology and Experimental Therapeutics December 2016, 359 (3) 460-470; DOI: https://doi.org/10.1124/jpet.116.236000