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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2016; Volume 359,Issue 2

Behavioral Pharmacology

  • You have access
    Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2
    Alessandra Matzeu, Tony M. Kerr, Friedbert Weiss and Rémi Martin-Fardon
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 273-279; DOI: https://doi.org/10.1124/jpet.116.235945
  • You have access
    Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice
    Giulia Donvito, Jenny L. Wilkerson, M. Imad Damaj and Aron H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 310-318; DOI: https://doi.org/10.1124/jpet.116.236182
  • You have access
    Stratification of Cannabinoid 1 Receptor (CB1R) Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice Reveals Congruence between In Vivo and In Vitro Assays
    T. W. Grim, A. J. Morales, M. M. Gonek, J. L. Wiley, B. F. Thomas, G. W. Endres, L. J. Sim-Selley, D. E. Selley, S. S. Negus and A. H. Lichtman
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 329-339; DOI: https://doi.org/10.1124/jpet.116.233163
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    Intranasal Opioid Administration in Rhesus Monkeys: PET Imaging and Antinociception
    Phillip A. Saccone, Angela M. Lindsey, Robert A. Koeppe, Kathy A. Zelenock, Xia Shao, Phillip Sherman, Carole A. Quesada, James H. Woods and Peter J. H. Scott
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 366-373; DOI: https://doi.org/10.1124/jpet.116.235192

Cardiovascular

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    Rostral Ventrolateral Medulla EP3 Receptor Mediates the Sympathoexcitatory and Pressor Effects of Prostaglandin E2 in Conscious Rats
    Samar Rezq and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 290-299; DOI: https://doi.org/10.1124/jpet.116.233502

Cellular and Molecular

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    Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons
    Raehannah J. Jamshidi, Laura C. Sullivan, Blaine A. Jacobs, Teresa A. Chavera, Kelly A. Berg and William P. Clarke
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 319-328; DOI: https://doi.org/10.1124/jpet.116.235184

Drug Discovery and Translational Medicine

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    Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment
    Fábio H. Silva, Serkan Karakus, Biljana Musicki, Hotaka Matsui, Trinity J. Bivalacqua, Jean L. dos Santos, Fernando F. Costa and Arthur L. Burnett
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 230-237; DOI: https://doi.org/10.1124/jpet.116.235473
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    High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer
    Winston Vuong, Ben Y. Tew, Gillian H. Little, Baruch Frenkel and Jeremy O. Jones
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 256-261; DOI: https://doi.org/10.1124/jpet.116.234567
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    Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke
    HyeonJu Kim, Ying Wei, Ji Yong Lee, Yue Wu, Yi Zheng, Michael A. Moskowitz and John W. Chen
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 262-272; DOI: https://doi.org/10.1124/jpet.116.235127
  • Open Access
    Renal Effects of Antisense-Mediated Inhibition of SGLT2
    Leonie van Meer, Matthijs Moerland, Marloes van Dongen, Bas Goulouze, Marieke de Kam, Erica Klaassen, Adam Cohen and Jacobus Burggraaf
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 280-289; DOI: https://doi.org/10.1124/jpet.116.233809
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    Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
    Mark R. Kelley, James H. Wikel, Chunlu Guo, Karen E. Pollok, Barbara J. Bailey, Randy Wireman, Melissa L. Fishel and Michael R. Vasko
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 300-309; DOI: https://doi.org/10.1124/jpet.116.235283
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    Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior
    Kwok H. C. Choy, David M. Shackleford, Daniel T. Malone, Shailesh N. Mistry, Rahul T. Patil, Peter J. Scammells, Christopher J. Langmead, Christos Pantelis, Patrick M. Sexton, Johnathan R. Lane and Arthur Christopoulos
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 354-365; DOI: https://doi.org/10.1124/jpet.116.235788

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    L-Arginine L-Glutamate Enhances Gastric Motor Function in Rats and Dogs and Improves Delayed Gastric Emptying in Dogs
    Ikumi Ishibashi-Shiraishi, Seiji Shiraishi, Shinichi Fujita, Saori Ogawa, Masahiko Kaneko, Manabu Suzuki and Tatsuro Tanaka
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 238-246; DOI: https://doi.org/10.1124/jpet.116.234658
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    Swertiamarin Attenuates Experimental Rat Hepatic Fibrosis by Suppressing Angiotensin II–Angiotensin Type 1 Receptor–Extracellular Signal-Regulated Kinase Signaling
    Shu Li, Qinglan Wang, Yanyan Tao and Chenghai Liu
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 247-255; DOI: https://doi.org/10.1124/jpet.116.234179
  • Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation
    Open Access
    Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation
    Jianqiao Zhang, Leiming Zhang, Xue Sun, Yanting Yang, Liang Kong, Chengwen Lu, Guangyao Lv, Tian Wang, Hongbo Wang and Fenghua Fu
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 374-382; DOI: https://doi.org/10.1124/jpet.116.233841

Neuropharmacology

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    LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells
    Maria C. Olianas, Simona Dedoni and Pierluigi Onali
    Journal of Pharmacology and Experimental Therapeutics November 2016, 359 (2) 340-353; DOI: https://doi.org/10.1124/jpet.116.236455
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Journal of Pharmacology and Experimental Therapeutics: 359 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 359, Issue 2
1 Nov 2016
  • Table of Contents
  • Table of Contents (PDF)
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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