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Research ArticleCardiovascular

Endothelium-Dependent Contractions of Isolated Arteries to Thymoquinone Require Biased Activity of Soluble Guanylyl Cyclase with Subsequent Cyclic IMP Production

Charlotte M. Detremmerie, Zhengju Chen, Zhuoming Li, Khalid M. Alkharfy, Susan W.S. Leung, Aimin Xu, Yuansheng Gao and Paul M. Vanhoutte
Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 558-568; DOI: https://doi.org/10.1124/jpet.116.234153
Charlotte M. Detremmerie
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Zhengju Chen
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Zhuoming Li
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Khalid M. Alkharfy
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Susan W.S. Leung
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Aimin Xu
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Yuansheng Gao
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Paul M. Vanhoutte
Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
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Article Information

vol. 358 no. 3 558-568
DOI 
https://doi.org/10.1124/jpet.116.234153
PubMed 
27335436

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 2, 2016
  • Accepted June 15, 2016
  • Published online August 17, 2016.

Article Versions

  • Earlier version (June 22, 2016 - 10:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Charlotte M. Detremmerie,
  2. Zhengju Chen,
  3. Zhuoming Li1,
  4. Khalid M. Alkharfy,
  5. Susan W.S. Leung,
  6. Aimin Xu,
  7. Yuansheng Gao, and
  8. Paul M. Vanhoutte
  1. Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong S.A.R., China (C.M.D., Z.L., S.W.S.L., A.X., P.M.V.); Department of Clinical Pharmacy, King Saud University, Saudi Arabia (K.M.A.) and Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China (Z.C., Y.G.)
  1. Address correspondence to:
    Dr. Charlotte M. Detremmerie, Department of Pharmacology and Pharmacy, University of Hong Kong, 2/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China. E-mail: cdetremm{at}hku.hk
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Journal of Pharmacology and Experimental Therapeutics: 358 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 358, Issue 3
1 Sep 2016
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Research ArticleCardiovascular

Vasoconstrictions Requiring Biased Activity of sGC

Charlotte M. Detremmerie, Zhengju Chen, Zhuoming Li, Khalid M. Alkharfy, Susan W.S. Leung, Aimin Xu, Yuansheng Gao and Paul M. Vanhoutte
Journal of Pharmacology and Experimental Therapeutics September 1, 2016, 358 (3) 558-568; DOI: https://doi.org/10.1124/jpet.116.234153

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Research ArticleCardiovascular

Vasoconstrictions Requiring Biased Activity of sGC

Charlotte M. Detremmerie, Zhengju Chen, Zhuoming Li, Khalid M. Alkharfy, Susan W.S. Leung, Aimin Xu, Yuansheng Gao and Paul M. Vanhoutte
Journal of Pharmacology and Experimental Therapeutics September 1, 2016, 358 (3) 558-568; DOI: https://doi.org/10.1124/jpet.116.234153
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