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Research ArticleCardiovascular

Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation

Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591
Mitsuru Seki
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Ryan LaCanna
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Jeffery C. Powers
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Christine Vrakas
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Fang Liu
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Remus Berretta
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Geena Chacko
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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John Holten
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Pooja Jadiya
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Tao Wang
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Jeffery S. Arkles
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Joshua M. Copper
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Steven R. Houser
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Jianhe Huang
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Vickas V. Patel
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Fabio A. Recchia
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
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Article Information

vol. 358 no. 3 441-449
DOI 
https://doi.org/10.1124/jpet.116.234591
PubMed 
27353074

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 23, 2016
  • Accepted June 22, 2016
  • Published online August 1, 2016.

Article Versions

  • Earlier version (June 27, 2016 - 08:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mitsuru Seki1,
  2. Ryan LaCanna1,
  3. Jeffery C. Powers1,
  4. Christine Vrakas1,
  5. Fang Liu,
  6. Remus Berretta,
  7. Geena Chacko,
  8. John Holten,
  9. Pooja Jadiya,
  10. Tao Wang,
  11. Jeffery S. Arkles,
  12. Joshua M. Copper,
  13. Steven R. Houser,
  14. Jianhe Huang,
  15. Vickas V. Patel, and
  16. Fabio A. Recchia
  1. Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
  1. Address correspondence to:
    Dr. Fabio A. Recchia, Lewis Katz School of Medicine, Medical Education and Research Building 1054, 3500 North Broad Street, Philadelphia, PA 19140. E-mail: fabio.recchia{at}temple.edu or Dr. Vickas Patel, Lewis Katz School of Medicine, MERB 1058, 3500 North Broad Street, Philadelphia, PA 19140. E-mail: vickas.patel{at}temple.edu
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Journal of Pharmacology and Experimental Therapeutics: 358 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 358, Issue 3
1 Sep 2016
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Research ArticleCardiovascular

Class I HDAC Inhibition in Atrial Fibrillation

Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
Journal of Pharmacology and Experimental Therapeutics September 1, 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591

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Research ArticleCardiovascular

Class I HDAC Inhibition in Atrial Fibrillation

Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
Journal of Pharmacology and Experimental Therapeutics September 1, 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591
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