Research ArticleCardiovascular
Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation
Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591
Mitsuru Seki
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Ryan LaCanna
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Jeffery C. Powers
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Christine Vrakas
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Fang Liu
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Remus Berretta
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Geena Chacko
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
John Holten
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Pooja Jadiya
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Tao Wang
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Jeffery S. Arkles
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Joshua M. Copper
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Steven R. Houser
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Jianhe Huang
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Vickas V. Patel
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)
Fabio A. Recchia
Cardiovascular Research Center (M.S., R.L.C., J.C.P., C.V., R.B., G.C., Jo.H., P.J., T.W., S.R.H., Ji.H., V.V.P., F.A.R.), and Section of Clinical Cardiac Electrophysiology (J.S.A., J.M.C., V.V.P.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.); and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania (F.L.)

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Research ArticleCardiovascular
Class I HDAC Inhibition in Atrial Fibrillation
Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
Journal of Pharmacology and Experimental Therapeutics September 1, 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591
Research ArticleCardiovascular
Class I HDAC Inhibition in Atrial Fibrillation
Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
Journal of Pharmacology and Experimental Therapeutics September 1, 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591
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