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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2016; Volume 358,Issue 3

Minireview

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    Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia
    Yutaka Nakagawa and Kenji Chiba
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 504-515; DOI: https://doi.org/10.1124/jpet.116.234476

Cardiovascular

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    Apixaban Inhibits Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits
    Xueping Zhou, Weizhen Wu, Lin Chu, David E. Gutstein, Dietmar Seiffert and Xinkang Wang
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 405-412; DOI: https://doi.org/10.1124/jpet.116.234575
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    Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms
    Athanasia Chatzianastasiou, Sofia-Iris Bibli, Ioanna Andreadou, Panagiotis Efentakis, Nina Kaludercic, Mark E. Wood, Matthew Whiteman, Fabio Di Lisa, Andreas Daiber, Vangelis G. Manolopoulos, Csaba Szabó and Andreas Papapetropoulos
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 431-440; DOI: https://doi.org/10.1124/jpet.116.235119
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    Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation
    Mitsuru Seki, Ryan LaCanna, Jeffery C. Powers, Christine Vrakas, Fang Liu, Remus Berretta, Geena Chacko, John Holten, Pooja Jadiya, Tao Wang, Jeffery S. Arkles, Joshua M. Copper, Steven R. Houser, Jianhe Huang, Vickas V. Patel and Fabio A. Recchia
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 441-449; DOI: https://doi.org/10.1124/jpet.116.234591
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    Spinal Neuronal NOS Signaling Contributes to Morphine Cardioprotection in Ischemia Reperfusion Injury in Rats
    Lingling Jiang, Jun Hu, Shufang He, Li Zhang and Ye Zhang
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 450-456; DOI: https://doi.org/10.1124/jpet.116.234021
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    A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase
    Alexandra E. Soto-Piña, Cynthia Franklin, C.S. Sheela Rani, Helmut Gottlieb, Carmen Hinojosa-Laborde and Randy Strong
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 528-536; DOI: https://doi.org/10.1124/jpet.116.234005
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    CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats
    Kiyoshi Arai, Yuka Morikawa, Naoko Ubukata, Hiroyuki Tsuruoka and Tsuyoshi Homma
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 548-557; DOI: https://doi.org/10.1124/jpet.116.234765
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    Endothelium-Dependent Contractions of Isolated Arteries to Thymoquinone Require Biased Activity of Soluble Guanylyl Cyclase with Subsequent Cyclic IMP Production
    Charlotte M. Detremmerie, Zhengju Chen, Zhuoming Li, Khalid M. Alkharfy, Susan W.S. Leung, Aimin Xu, Yuansheng Gao and Paul M. Vanhoutte
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 558-568; DOI: https://doi.org/10.1124/jpet.116.234153

Chemotherapy, Antibiotics, and Gene Therapy

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    Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model
    Tatsuhiko Harada, Yuji Ishimatsu, Atsuko Hara, Towako Morita, Shota Nakashima, Tomoyuki Kakugawa, Noriho Sakamoto, Kosuke Kosai, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae and Shigeru Kohno
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 457-463; DOI: https://doi.org/10.1124/jpet.116.233932

Drug Discovery and Translational Medicine

  • Open Access
    Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
    Walter Kostich, Brian D. Hamman, Yu-Wen Li, Sreenivasulu Naidu, Kumaran Dandapani, Jianlin Feng, Amy Easton, Clotilde Bourin, Kevin Baker, Jason Allen, Katerina Savelieva, Justin V. Louis, Manoj Dokania, Saravanan Elavazhagan, Pradeep Vattikundala, Vivek Sharma, Manish Lal Das, Ganesh Shankar, Anoop Kumar, Vinay K. Holenarsipur, Michael Gulianello, Ted Molski, Jeffrey M. Brown, Martin Lewis, Yanling Huang, Yifeng Lu, Rick Pieschl, Kevin O’Malley, Jonathan Lippy, Amr Nouraldeen, Thomas H. Lanthorn, Guilan Ye, Alan Wilson, Anand Balakrishnan, Rex Denton, James E. Grace, Kimberley A. Lentz, Kenneth S. Santone, Yingzhi Bi, Alan Main, Jon Swaffield, Ken Carson, Sandhya Mandlekar, Reeba K. Vikramadithyan, Susheel J. Nara, Carolyn Dzierba, Joanne Bronson, John E. Macor, Robert Zaczek, Ryan Westphal, Laszlo Kiss, Linda Bristow, Charles M. Conway, Brian Zambrowicz and Charles F. Albright
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 371-386; DOI: https://doi.org/10.1124/jpet.116.235333
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    Differential Binding Activity of TGF-β Family Proteins to Select TGF-β Receptors
    Ashraf M. Khalil, Hyna Dotimas, Julius Kahn, Jane E. Lamerdin, David B. Hayes, Priyanka Gupta and Michael Franti
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 423-430; DOI: https://doi.org/10.1124/jpet.116.232322
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    Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676
    Katarina Varnäs, Anders Juréus, Peter Johnström, Charlotte Ahlgren, Pär Schött, Magnus Schou, Susanne Gruber, Eva Jerning, Jonas Malmborg, Christer Halldin, Lovisa Afzelius and Lars Farde
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 464-471; DOI: https://doi.org/10.1124/jpet.116.234146
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    Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice
    Kurt Giles, David B. Berry, Carlo Condello, Brittany N. Dugger, Zhe Li, Abby Oehler, Sumita Bhardwaj, Manuel Elepano, Shenheng Guan, B. Michael Silber, Steven H. Olson and Stanley B. Prusiner
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 537-547; DOI: https://doi.org/10.1124/jpet.116.235556

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Inhibition of α2A-Adrenoceptors Ameliorates Dextran Sulfate Sodium–Induced Acute Intestinal Inflammation in Mice
    Zoltán S. Zádori, Viktória E. Tóth, Ágnes Fehér, Mahmoud Al-Khrasani, Zita Puskár, Márk Kozsurek, Júlia Timár, Tamás Tábi, Zsuzsanna Helyes, Lutz Hein, Peter Holzer and Klára Gyires
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 483-491; DOI: https://doi.org/10.1124/jpet.116.235101

Inflammation, Immunopharmacology, and Asthma

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    Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes
    Chen Dong, Charlotte Virtucio, Olga Zemska, Grober Baltazar, Yasheen Zhou, Diogo Baia, Shannon Jones-Iatauro, Holly Sexton, Shamra Martin, Joshua Dee, Yvonne Mak, Maliwan Meewan, Fernando Rock, Tsutomu Akama and Kurt Jarnagin
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 413-422; DOI: https://doi.org/10.1124/jpet.116.232819
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    Acetaminophen Attenuates House Dust Mite–Induced Allergic Airway Disease in Mice
    Gregory J. Smith, Roger S. Thrall, Michelle M. Cloutier, Jose E. Manautou and John B. Morris
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 569-579; DOI: https://doi.org/10.1124/jpet.116.233684

Metabolism, Transport, and Pharmacogenomics

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    Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition
    Yurong Lai, Sandhya Mandlekar, Hong Shen, Vinay K. Holenarsipur, Robert Langish, Prabhakar Rajanna, Senthilkumar Murugesan, Nilesh Gaud, Sabariya Selvam, Onkar Date, Yaofeng Cheng, Petia Shipkova, Jun Dai, William G. Humphreys and Punit Marathe
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 397-404; DOI: https://doi.org/10.1124/jpet.116.234914

Neuropharmacology

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    Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain
    Ellen Hewitt, Thomas Pitcher, Biljana Rizoska, Karin Tunblad, Ian Henderson, Britt-Louise Sahlberg, Urszula Grabowska, Björn Classon, Charlotte Edenius, Marzia Malcangio and Erik Lindström
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 387-396; DOI: https://doi.org/10.1124/jpet.116.232926
  • Open Access
    Task- and Treatment Length–Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats
    Alan L. Pehrson, Todd M. Hillhouse, Nasser Haddjeri, Renaud Rovera, Joseph H. Porter, Arne Mørk, Gennady Smagin, Dekun Song, David Budac, Manuel Cajina and Connie Sanchez
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 472-482; DOI: https://doi.org/10.1124/jpet.116.233924
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    Intrathecal Intermittent Orexin-A Causes Sympathetic Long-Term Facilitation and Sensitizes the Peripheral Chemoreceptor Response to Hypoxia in Rats
    Seung Jae Kim, Paul M. Pilowsky and Melissa M. J. Farnham
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 492-501; DOI: https://doi.org/10.1124/jpet.116.234443
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    The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal
    Marianna E. Jung, Daniel B. Metzger and Hriday K. Das
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 516-526; DOI: https://doi.org/10.1124/jpet.116.233361
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    Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay
    Eva Martínez-Pinilla, Obdulia Rabal, Irene Reyes-Resina, Marta Zamarbide, Gemma Navarro, Juan A. Sánchez-Arias, Irene de Miguel, José L. Lanciego, Julen Oyarzabal and Rafael Franco
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 580-587; DOI: https://doi.org/10.1124/jpet.116.234948

Letters to the Editor

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    A Comment on “Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8”
    Jeffrey M. Witkin and Kevin M. Gardinier
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 502-503; DOI: https://doi.org/10.1124/jpet.116.234419

Response Letters

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    Reply to “A Comment on ‘Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8’”
    Michael P. Maher, Michael K. Ameriks, Brad M. Savall, Nicholas I. Carruthers and Timothy W. Lovenberg
    Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 527; DOI: https://doi.org/10.1124/jpet.116.234815
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 358 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 358, Issue 3
1 Sep 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Minireview
  • Cardiovascular
  • Chemotherapy, Antibiotics, and Gene Therapy
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Letters to the Editor
  • Response Letters
  • Most Cited
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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