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Research ArticleBehavioral Pharmacology

The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits

J. M. Witkin, J. A. Monn, D. D. Schoepp, X. Li, C. Overshiner, S. N. Mitchell, G. Carter, B. Johnson, K. Rasmussen and L. M. Rorick-Kehn
Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 71-82; DOI: https://doi.org/10.1124/jpet.116.233627

Article Information

vol. 358 no. 1 71-82
DOI 
https://doi.org/10.1124/jpet.116.233627
PubMed 
27189960
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 18, 2016
  • Accepted May 10, 2016
  • Published online June 8, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. M. Witkin,
  2. J. A. Monn,
  3. D. D. Schoepp,
  4. X. Li,
  5. C. Overshiner,
  6. S. N. Mitchell,
  7. G. Carter,
  8. B. Johnson,
  9. K. Rasmussen, and
  10. L. M. Rorick-Kehn
  1. Departments of Neuroscience and Discovery Chemistry, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana (J.M.W., J.A.M., D.D.S., X.L., C.O., B.J., K.R., L.M.R.-K.), and Windlesham, Surrey, UK (S.N.M., G.C.)
  1. Address correspondence to:
    Dr. Jeffrey M. Witkin, Lilly Research Laboratories; Lilly Corporate Center, Indianapolis, IN 46285-0510. E-mail: jwitkin{at}lilly.com
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Research ArticleBehavioral Pharmacology

Rapidly Acting Antidepressant Actions of LY341495

J. M. Witkin, J. A. Monn, D. D. Schoepp, X. Li, C. Overshiner, S. N. Mitchell, G. Carter, B. Johnson, K. Rasmussen and L. M. Rorick-Kehn
Journal of Pharmacology and Experimental Therapeutics July 1, 2016, 358 (1) 71-82; DOI: https://doi.org/10.1124/jpet.116.233627
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