Table of Contents

Drug Discovery and Translational Medicine

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  Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice

  John Oberdick, Yonghua Ling, Mitch A. Phelps, Max S. Yudovich, Karl Schilling and Wolfgang Sadee

  Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 22-30; DOI: https://doi.org/10.1124/jpet.115.231902
• Open Access

  Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

  Jeremy H. Toyn, Kenneth M. Boy, Joseph Raybon, Jere E. Meredith, Alan S. Robertson, Valerie Guss, Nina Hoque, Francis Sweeney, Xiaoliang Zhuo, Wendy Clarke, Kimberly Snow, R. Rex Denton, Dmitry Zuev, Lorin A. Thompson, John Morrison, James Grace, Flora Berisha, Michael Furlong, Jun-Sheng Wang, Kimberly A. Lentz, Ramesh Padmanabha, Lynda Cook, Cong Wei, Dieter M. Drexler, John E. Macor, Charlie F. Albright, Maciej Gasior, Richard E. Olson, Quan Hong, Holly D. Soares, Malaz AbuTarif and Michael K. Ahlijanian

  Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 125-137; DOI: https://doi.org/10.1124/jpet.116.232249
• Open Access

  The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

  Holly D. Soares, Maciej Gasior, Jeremy H. Toyn, Jun-Sheng Wang, Quan Hong, Flora Berisha, Michael T. Furlong, Joseph Raybon, Kimberley A. Lentz, Francis Sweeney, Naiyu Zheng, Billy Akinsanya, Robert M. Berman, Lorin A. Thompson, Richard E. Olson, John Morrison, Dieter M. Drexler, John E. Macor, Charlie F. Albright, Michael K. Ahlijanian and Malaz AbuTarif

  Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 138-150; DOI: https://doi.org/10.1124/jpet.116.232256