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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

July 01, 2016; Volume 358,Issue 1

Minireview

  • You have access
    New Insight into the Dietary Cause of Atherosclerosis: Implications for Pharmacology
    Reynold Spector
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 103-108; DOI: https://doi.org/10.1124/jpet.116.233296

Behavioral Pharmacology

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    The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits
    J. M. Witkin, J. A. Monn, D. D. Schoepp, X. Li, C. Overshiner, S. N. Mitchell, G. Carter, B. Johnson, K. Rasmussen and L. M. Rorick-Kehn
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 71-82; DOI: https://doi.org/10.1124/jpet.116.233627
  • You have access
    Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists
    Jonathan L. Katz, Takato Hiranita, Theresa A. Kopajtic, Kenner C. Rice, Christophe Mesangeau, Sanju Narayanan, Ahmed H. Abdelazeem and Christopher R. McCurdy
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 109-124; DOI: https://doi.org/10.1124/jpet.116.232728

Cardiovascular

  • Vascular and Central Activation of Peroxisome Proliferator–Activated Receptor-<em>β</em> Attenuates Angiotensin II–Induced Hypertension: Role of RGS-5
    You have access
    Vascular and Central Activation of Peroxisome Proliferator–Activated Receptor-β Attenuates Angiotensin II–Induced Hypertension: Role of RGS-5
    Miguel Romero, Rosario Jiménez, Marta Toral, Elvira León-Gómez, Manuel Gómez-Gúzman, Manuel Sánchez, María José Zarzuelo, Isabel Rodríguez-Gómez, Geraldine Rath, Juan Tamargo, Francisco Pérez-Vizcaíno, Chantal Dessy and Juan Duarte
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 151-163; DOI: https://doi.org/10.1124/jpet.116.233106

Drug Discovery and Translational Medicine

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    Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice
    John Oberdick, Yonghua Ling, Mitch A. Phelps, Max S. Yudovich, Karl Schilling and Wolfgang Sadee
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 22-30; DOI: https://doi.org/10.1124/jpet.115.231902
  • Open Access
    Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
    Jeremy H. Toyn, Kenneth M. Boy, Joseph Raybon, Jere E. Meredith, Alan S. Robertson, Valerie Guss, Nina Hoque, Francis Sweeney, Xiaoliang Zhuo, Wendy Clarke, Kimberly Snow, R. Rex Denton, Dmitry Zuev, Lorin A. Thompson, John Morrison, James Grace, Flora Berisha, Michael Furlong, Jun-Sheng Wang, Kimberly A. Lentz, Ramesh Padmanabha, Lynda Cook, Cong Wei, Dieter M. Drexler, John E. Macor, Charlie F. Albright, Maciej Gasior, Richard E. Olson, Quan Hong, Holly D. Soares, Malaz AbuTarif and Michael K. Ahlijanian
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 125-137; DOI: https://doi.org/10.1124/jpet.116.232249
  • Open Access
    The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers
    Holly D. Soares, Maciej Gasior, Jeremy H. Toyn, Jun-Sheng Wang, Quan Hong, Flora Berisha, Michael T. Furlong, Joseph Raybon, Kimberley A. Lentz, Francis Sweeney, Naiyu Zheng, Billy Akinsanya, Robert M. Berman, Lorin A. Thompson, Richard E. Olson, John Morrison, Dieter M. Drexler, John E. Macor, Charlie F. Albright, Michael K. Ahlijanian and Malaz AbuTarif
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 138-150; DOI: https://doi.org/10.1124/jpet.116.232256

Endocrine and Diabetes

  • Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 Inhibitor Canagliflozin with SGLT1 and SGLT2: Inhibition Kinetics, Sidedness of Action, and Transporter-Associated Incorporation Accounting for its Pharmacodynamic and Pharmacokinetic Features
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    Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 Inhibitor Canagliflozin with SGLT1 and SGLT2: Inhibition Kinetics, Sidedness of Action, and Transporter-Associated Incorporation Accounting for its Pharmacodynamic and Pharmacokinetic Features
    Ryuichi Ohgaki, Ling Wei, Kazunori Yamada, Taiki Hara, Chiaki Kuriyama, Suguru Okuda, Kiichiro Ueta, Masaharu Shiotani, Shushi Nagamori and Yoshikatsu Kanai
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 94-102; DOI: https://doi.org/10.1124/jpet.116.232025

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Nuclear Factor Erythroid 2–Related Factor 2 Deficiency Results in Amplification of the Liver Fat-Lowering Effect of Estrogen
    Wenjuan Rui, Yuhong Zou, Joonyong Lee, Shashank Manohar Nambiar, Jingmei Lin, Linjie Zhang, Yan Yang and Guoli Dai
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 14-21; DOI: https://doi.org/10.1124/jpet.115.231316
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    Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes
    Guangbi Li, Min Xia, Justine M. Abais, Krishna Boini, Pin-Lan Li and Joseph K. Ritter
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 61-70; DOI: https://doi.org/10.1124/jpet.116.233239

Inflammation, Immunopharmacology, and Asthma

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    Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages
    Ji-Sun Shin, Hye-Eun Choi, SeungHwan Seo, Jung-Hye Choi, Nam-In Baek and Kyung-Tae Lee
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 3-13; DOI: https://doi.org/10.1124/jpet.115.231043

Metabolism, Transport, and Pharmacogenomics

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    Physiological Content and Intrinsic Activities of 10 Cytochrome P450 Isoforms in Human Normal Liver Microsomes
    Hai-Feng Zhang, Huan-Huan Wang, Na Gao, Jun-Ying Wei, Xin Tian, Yan Zhao, Yan Fang, Jun Zhou, Qiang Wen, Jie Gao, Yang-Jun Zhang, Xiao-Hong Qian and Hai-Ling Qiao
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 83-93; DOI: https://doi.org/10.1124/jpet.116.233635

Neuropharmacology

  • Open Access
    Ethanol Tolerance Affects Endogenous Adenosine Signaling in Mouse Hippocampus
    Dali Zhang, Wei Xiong, Michael F. Jackson and Fiona E. Parkinson
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 31-38; DOI: https://doi.org/10.1124/jpet.116.232231
  • You have access
    Endogenous 5-HT2C Receptors Phosphorylate the cAMP Response Element Binding Protein via Protein Kinase C-Promoted Activation of Extracellular-Regulated Kinases-1/2 in Hypothalamic mHypoA-2/10 Cells
    Lisa Lauffer, Evi Glas, Thomas Gudermann and Andreas Breit
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 39-49; DOI: https://doi.org/10.1124/jpet.116.232397

Toxicology

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    Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice
    Alexander W. Alund, Kelly E. Mercer, Larry J. Suva, Casey F. Pulliam, Jin-Ran Chen, Thomas M. Badger, Holly Van Remmen and Martin J. J. Ronis
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 50-60; DOI: https://doi.org/10.1124/jpet.116.233213

Erratum

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    Correction to “1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438), a Novel and Potent Potassium-Competitive Acid Blocker for the Treatment of Acid-Related Diseases.”
    Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 1-2; DOI: https://doi.org/10.1124/jpet.115.170120err
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 358 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 358, Issue 1
1 Jul 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Minireview
  • Behavioral Pharmacology
  • Cardiovascular
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Toxicology
  • Erratum
  • Most Cited
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.
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