Research ArticleDrug Discovery and Translational Medicine
β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1– and Oxidative Stress–Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis
Yougen Wu, Xue Wang, Siyu Chang, Weiqiang Lu, Mingyao Liu and Xiufeng Pang
Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 466-475; DOI: https://doi.org/10.1124/jpet.116.232694
Yougen Wu
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (Y.W., X.W., S.C.,W.L., M.L., X.P.); Central Laboratory, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China (Y.W.); and Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (M.L.)
Xue Wang
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (Y.W., X.W., S.C.,W.L., M.L., X.P.); Central Laboratory, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China (Y.W.); and Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (M.L.)
Siyu Chang
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (Y.W., X.W., S.C.,W.L., M.L., X.P.); Central Laboratory, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China (Y.W.); and Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (M.L.)
Weiqiang Lu
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (Y.W., X.W., S.C.,W.L., M.L., X.P.); Central Laboratory, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China (Y.W.); and Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (M.L.)
Mingyao Liu
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (Y.W., X.W., S.C.,W.L., M.L., X.P.); Central Laboratory, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China (Y.W.); and Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (M.L.)
Xiufeng Pang
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (Y.W., X.W., S.C.,W.L., M.L., X.P.); Central Laboratory, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China (Y.W.); and Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas (M.L.)
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Research ArticleDrug Discovery and Translational Medicine
β-Lapachone Induces Hsp90 Cleavage
Yougen Wu, Xue Wang, Siyu Chang, Weiqiang Lu, Mingyao Liu and Xiufeng Pang
Journal of Pharmacology and Experimental Therapeutics June 1, 2016, 357 (3) 466-475; DOI: https://doi.org/10.1124/jpet.116.232694
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