Journal of Pharmacology and Experimental Therapeutics: 357 (3)

June 01, 2016; Volume 357,Issue 3

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Dopamine Reuptake Inhibitors in Parkinson’s Disease: A Review of Nonhuman Primate Studies and Clinical Trials
Philippe Huot, Susan H. Fox and Jonathan M. Brotchie

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 562-569; DOI: https://doi.org/10.1124/jpet.116.232371

Behavioral Pharmacology

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Antinociceptive Interactions between the Imidazoline I₂ Receptor Agonist 2-BFI and Opioids in Rats: Role of Efficacy at the μ-Opioid Receptor
Justin N. Siemian, Samuel Obeng, Yan Zhang, Yanan Zhang and Jun-Xu Li

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 509-519; DOI: https://doi.org/10.1124/jpet.116.232421
Open Access
Analysis of β-Subunit-dependent GABA_A Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives
S. Khom, J. Hintersteiner, D. Luger, M. Haider, G. Pototschnig, M. D. Mihovilovic, C. Schwarzer and S. Hering

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 580-590; DOI: https://doi.org/10.1124/jpet.116.232983

Cardiovascular

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C-Type Natriuretic Peptide Improves Left Ventricular Functional Performance at Rest and Restores Normal Exercise Responses after Heart Failure
Tiankai Li, Heng-Jie Cheng, Nobuyuki Ohte, Hiroshi Hasegawa, Atsushi Morimoto, David M. Herrington, William C. Little, Weimin Li and Che Ping Cheng

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 545-553; DOI: https://doi.org/10.1124/jpet.115.231696

Drug Discovery and Translational Medicine

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β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1– and Oxidative Stress–Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis
Yougen Wu, Xue Wang, Siyu Chang, Weiqiang Lu, Mingyao Liu and Xiufeng Pang

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 466-475; DOI: https://doi.org/10.1124/jpet.116.232694
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Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity
Brian C. Geohagen, Amaresh Vydyanathan, Boleslav Kosharskyy, Naum Shaparin, Terrence Gavin and Richard M. LoPachin

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 476-486; DOI: https://doi.org/10.1124/jpet.115.231001
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TASP0434299: A Novel Pyridopyrimidin-4-One Derivative as a Radioligand for Vasopressin V_1B Receptor
Kazumi Koga, Mitsukane Yoshinaga, Yoshikatsu Uematsu, Yuji Nagai, Naoki Miyakoshi, Yoko Shimoda, Masayuki Fujinaga, Takafumi Minamimoto, Ming-Rong Zhang, Makoto Higuchi, Norikazu Ohtake, Tetsuya Suhara and Shigeyuki Chaki

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 495-508; DOI: https://doi.org/10.1124/jpet.116.232942
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BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells
David J. Lamb, Stefan Lutz Wollin, Andreas Schnapp, Daniel Bischoff, Klaus J. Erb, Thierry Bouyssou, Bernd Guilliard, Christine Strasser, Eva Wex, Sylvia Blum, Eva Thaler, Helga Nickel, Oliver Radmacher, Hannah Haas, Jennifer L. Swantek, Don Souza, Melissa Canfield, Della White, Mark Panzenbeck, Mohammed A. Kashem, Mary Sanville-Ross, Takeshi Kono, Katherina Sewald, Armin Braun, Helena Obernolte, Olga Danov, Gerhard Schaenzle, Georg Rast, Gerd-Michael Maier and Matthias Hoffmann

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 554-561; DOI: https://doi.org/10.1124/jpet.116.233155

Endocrine and Diabetes

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In Vivo and In Vitro Characterization of Basal Insulin Peglispro: A Novel Insulin Analog
Rebecca A. Owens, Ryan J. Hansen, Steven D. Kahl, Chen Zhang, Xiaoping Ruan, Anja Koester, Shun Li, Hui-Rong Qian, Mark W. Farmen, M. Dodson Michael, Julie S. Moyers, Gordon B. Cutler, Andrew Vick and John M. Beals

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 459-465; DOI: https://doi.org/10.1124/jpet.115.231035
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Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic β-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE₂Ki Mice on a Chronic High-Fat Diet
Amna Abderrazak, Khadija El Hadri, Elodie Bosc, Bertrand Blondeau, Mohamed-Naceur Slimane, Berthold Büchele, Thomas Simmet, Dominique Couchie and Mustapha Rouis

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 487-494; DOI: https://doi.org/10.1124/jpet.116.232934

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Protection from Cigarette Smoke–Induced Lung Dysfunction and Damage by H2 Relaxin (Serelaxin)
Alessandro Pini, Giulia Boccalini, Laura Lucarini, Stefano Catarinicchia, Daniele Guasti, Emanuela Masini, Daniele Bani and Silvia Nistri

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 451-458; DOI: https://doi.org/10.1124/jpet.116.232215
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Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation
Aravind R. Gade, Minho Kang, Fayez Khan, John R. Grider, M. Imad Damaj, William L. Dewey and Hamid I. Akbarali

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 520-528; DOI: https://doi.org/10.1124/jpet.116.233304
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Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers
Sumanta Kumar Goswami, Debin Wan, Jun Yang, Carlos A. Trindade da Silva, Christophe Morisseau, Sean D. Kodani, Guang-Yu Yang, Bora Inceoglu and Bruce D. Hammock

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 529-536; DOI: https://doi.org/10.1124/jpet.116.232108
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Pharmacology of Bradykinin-Evoked Coughing in Guinea Pigs
Matthew M. Hewitt, Gregory Adams, Stuart B. Mazzone, Nanako Mori, Li Yu and Brendan J. Canning

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 620-628; DOI: https://doi.org/10.1124/jpet.115.230383

Inflammation, Immunopharmacology, and Asthma

Open Access
Tiotropium Attenuates Virus-Induced Pulmonary Inflammation in Cigarette Smoke–Exposed Mice
Hannes Bucher, Matthias J. Duechs, Cornelia Tilp, Birgit Jung and Klaus J. Erb

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 606-618; DOI: https://doi.org/10.1124/jpet.116.232009

Metabolism, Transport, and Pharmacogenomics

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Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes
Vyvyca J. Walker, Alisha P. Griffin, Dagan K. Hammar and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 537-544; DOI: https://doi.org/10.1124/jpet.116.232553

Neuropharmacology

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Differential Potency of 2,6-Dimethylcyclohexanol Isomers for Positive Modulation of GABA_A Receptor Currents
Luvana Chowdhury, Celine J. Croft, Shikha Goel, Naina Zaman, Angela C.-S. Tai, Erin M. Walch, Kelly Smith, Alexandra Page, Kevin M. Shea, C. Dennis Hall, D. Jishkariani, Girinath G. Pillai and Adam C. Hall

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 570-579; DOI: https://doi.org/10.1124/jpet.115.228890
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Notoginsenoside R1 Protects against Neonatal Cerebral Hypoxic-Ischemic Injury through Estrogen Receptor–Dependent Activation of Endoplasmic Reticulum Stress Pathways
Yan Wang, Liu Tu, Yingbo Li, Di Chen and Shali Wang

Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 591-605; DOI: https://doi.org/10.1124/jpet.115.230359

Erratum

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Correction to “Combined Antiproliferative Effects of the Aminoalkylindole WIN55,212-2 and Radiation in Breast Cancer Cells”
Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 619; DOI: https://doi.org/10.1124/jpet.113.205120err

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Table of Contents

Minireview

Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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