Journal of Pharmacology and Experimental Therapeutics: 357 (2)

May 01, 2016; Volume 357,Issue 2

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Could Biomarkers Direct Therapy for the Septic Patient?
Clark R. Sims, Trung C. Nguyen and Philip R. Mayeux

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 228-239; DOI: https://doi.org/10.1124/jpet.115.230797

Behavioral Pharmacology

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Repeated Dosing with NCX1404, a Nitric Oxide–Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy
Katia Varani, Fabrizio Vincenzi, Martina Targa, Annalisa Ravani, Elena Bastia, Laura Storoni, Stefania Brambilla, Nicoletta Almirante and Francesco Impagnatiello

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 240-247; DOI: https://doi.org/10.1124/jpet.115.230193
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Role of Prostaglandin D₂ and DP₁ Receptor on Japanese Cedar Pollen-Induced Allergic Rhinitis in Mice
Yoshiyuki Nakano, Yujiro Kidani, Kumiko Goto, Shingo Furue, Yasuhiko Tomita, Naoki Inagaki, Hiroyuki Tanaka and Michitaka Shichijo

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 258-263; DOI: https://doi.org/10.1124/jpet.115.229799
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Prostaglandin D₂ Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs
Yoji Nagira, Kumiko Goto, Hiroyuki Tanaka, Miwa Aoki, Shingo Furue, Naoki Inagaki, Yasuhiko Tomita and Michitaka Shichijo

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 273-280; DOI: https://doi.org/10.1124/jpet.115.231225
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Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice
Miao-Kun Sun, Jarin Hongpaisan and Daniel L. Alkon

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 300-310; DOI: https://doi.org/10.1124/jpet.115.231100
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Combined Treatment with Morphine and Δ⁹-Tetrahydrocannabinol in Rhesus Monkeys: Antinociceptive Tolerance and Withdrawal
L. R. Gerak and C. P. France

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 357-366; DOI: https://doi.org/10.1124/jpet.115.231381
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Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector–Delivered Cocaine Hydrolase
John R. Smethells, Natashia Swalve, Stephen Brimijoin, Yang Gao, Robin J. Parks, Adam Greer and Marilyn E. Carroll

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 375-381; DOI: https://doi.org/10.1124/jpet.116.232504

Cardiovascular

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Digoxin-Mediated Upregulation of RGS2 Protein Protects against Cardiac Injury
Benita Sjögren, Sergio Parra, Kevin B. Atkins, Behirda Karaj and Richard R. Neubig

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 311-319; DOI: https://doi.org/10.1124/jpet.115.231571
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A Food and Drug Administration–Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion
Claudio A. Bravo, Dorothy E. Vatner, Ronald Pachon, Jie Zhang and Stephen F. Vatner

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 331-336; DOI: https://doi.org/10.1124/jpet.116.232538
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Essential Opposite Roles of ERK and Akt Signaling in Cardiac Steroid-Induced Increase in Heart Contractility
Nahum Buzaglo, Haim Rosen, Hagit Cohen Ben Ami, Adi Inbal and David Lichtstein

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 345-356; DOI: https://doi.org/10.1124/jpet.115.230763
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Off-Target Vascular Effects of Cholesteryl Ester Transfer Protein Inhibitors Involve Redox-Sensitive and Signal Transducer and Activator of Transcription 3–Dependent Pathways
Francisco J. Rios, Rheure A. Lopes, Karla B. Neves, Livia L. Camargo, Augusto C. Montezano and Rhian M. Touyz

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 415-422; DOI: https://doi.org/10.1124/jpet.115.230748

Drug Discovery and Translational Medicine

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Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse
Sarah Sushchyk, Zheng-Xiong Xi and Jia Bei Wang

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 248-257; DOI: https://doi.org/10.1124/jpet.115.229542
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Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B
Ayahisa Watanabe, Mado Nakajima, Takeshi Kasuya, Reina Onishi, Naohisa Kitade, Kei Mayumi, Tatsuya Ikehara and Akira Kugimiya

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 320-330; DOI: https://doi.org/10.1124/jpet.115.230300
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Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein–Coupled Receptor 84
Qing Zhang, Hui Yang, Jing Li and Xin Xie

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 337-344; DOI: https://doi.org/10.1124/jpet.116.232033
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Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies
Jane Kovalevich, Anne-Sophie Cornec, Yuemang Yao, Michael James, Alexander Crowe, Virginia M.-Y. Lee, John Q. Trojanowski, Amos B. Smith, Carlo Ballatore and Kurt R. Brunden

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 432-450; DOI: https://doi.org/10.1124/jpet.115.231175

Gastrointestinal, Hepatic, Pulmonary, and Renal

Open Access
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea
David W. Griggs, Michael J. Prinsen, Jonathan Oliva, Mary A. Campbell, Stacy D. Arnett, Deena Tajfirouz, Peter G. Ruminski, Ying Yu, Brian R. Bond, Yuhua Ji, Georg Neckermann, Robert K. M. Choy, Eugenio de Hostos and Marvin J. Meyers

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 423-431; DOI: https://doi.org/10.1124/jpet.115.231167

Metabolism, Transport, and Pharmacogenomics

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Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1
Robert S. Foti, Nina Isoherranen, Alex Zelter, Leslie J. Dickmann, Brian R. Buttrick, Philippe Diaz and Dominique Douguet

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 281-292; DOI: https://doi.org/10.1124/jpet.116.232637
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Phenobarbital and Insulin Reciprocate Activation of the Nuclear Receptor Constitutive Androstane Receptor through the Insulin Receptor
Tomoya Yasujima, Kosuke Saito, Rick Moore and Masahiko Negishi

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 367-374; DOI: https://doi.org/10.1124/jpet.116.232140
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Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species
Hong Shen, Jun Dai, Tongtong Liu, Yaofeng Cheng, Weiqi Chen, Chris Freeden, Yingru Zhang, W. Griffith Humphreys, Punit Marathe and Yurong Lai

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 382-393; DOI: https://doi.org/10.1124/jpet.116.232066

Neuropharmacology

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Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum
Jenni Kononoff Vanhanen, Saara Nuutinen, Mervi Tuominen and Pertti Panula

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 264-272; DOI: https://doi.org/10.1124/jpet.115.230771
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Effect of Melatonin and 5-Methoxycarbonylamino-N-Acetyltryptamine on the Intraocular Pressure of Normal and Glaucomatous Mice
Alejandro Martínez-Águila, Begoña Fonseca, María J. Pérez de Lara and Jesús Pintor

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 293-299; DOI: https://doi.org/10.1124/jpet.115.231456
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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8
Michael P. Maher, Nyantsz Wu, Suchitra Ravula, Michael K. Ameriks, Brad M. Savall, Changlu Liu, Brian Lord, Ryan M. Wyatt, Jose A. Matta, Christine Dugovic, Sujin Yun, Luc Ver Donck, Thomas Steckler, Alan D. Wickenden, Nicholas I. Carruthers and Timothy W. Lovenberg

Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 394-414; DOI: https://doi.org/10.1124/jpet.115.231712

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Table of Contents

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Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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